Abstract: The present disclosure relates to compositions and methods for treating cancers. In particular, the present disclosure provides materials and methods for identifying mis-splicing-associated surface antigens (MASAs) generated by altered spliceosome proteins, as well as materials and methods for targeting cancerous tumors expressing MASAs.

Abstract: A composition and method of using are provided, which composition includes: at least one compound selected from the group including a compound having formula (I), a salt thereof, a prodrug thereof, a compound having formula (II), a salt thereof, a prodrug thereof, and a combination thereof, the compounds being described herein, and a combination thereof, and at least one pharmaceutically acceptable carrier; wherein the composition is suitable for administration to a mammal. Methods of using the compound are also provided.

Abstract: An isolated nucleic acid molecule comprising a modified Murine Leukemia Virus Long Terminal Repeat sequence that is capable of tropically regulating expression of operably linked coding sequences in a vessel endothelial cell is disclosed. A method of producing a non-Murine Leukemia Virus protein in a vessel endothelial cell is disclosed. The method comprises the step of introducing into the cell a nucleic acid molecule that comprises a modified Murine Leukemia Virus Long Terminal Repeat sequences operably linked to a nucleotide sequence which encodes a non-Murine Leukemia Virus protein, the modified Murine Leukemia Virus Long Terminal Repeat sequences being capable of tropically regulating expression in vessel endothelial cells.