Abstract: Several traveling wave grid systems are disclosed that may be used to concentrate and form highly localized regions of bio-agents or other charged species. In addition, specific detection systems are described that enable currently available detectors and sensors, including those to be developed in the future, to be used for measuring the presence and concentration of certain bio-agents or charged particles, which otherwise are present at concentrations too low to readily detect or measure.

Abstract: Various traveling wave grids and electrophoretic systems, and electrode assemblies using such grids, are disclosed. A configuration in which a voltage potential is used to load a biomolecule sample against a grid is disclosed. A unique strategy of using multiple, reconfigurable grids in such systems is also described. The strategy involves initially conducting a broad protein separation and then selectively tailoring one or more grids, and conducting one or more secondary processing operations. Related strategies and specific methods are additionally disclosed for separating samples of biomolecules and components thereof using the noted systems, assemblies, and grids.

Abstract: Various gel electrophoretic assemblies and techniques are disclosed for providing unique isoelectric focusing (IEF) strategies. Several particular systems, assemblies and methods are provided that significantly reduce processing time, enable the use of reduced operating voltages, and produce analytical results with improved resolution.

Abstract: A sample manipulator that utilizes electrostatic traveling waves to selectively displace one or more samples deposited on its face is disclosed. The sample manipulator enables an operator to perform a wide variety of processes upon the deposited samples. Also disclosed are strategies for separating two or more samples, focusing a sample, and passing a reagent through a sample, all conducted on the face of the sample manipulator.

Abstract: Disclosed is a compact, non-contacting device for collecting samples, and particularly minute quantities of bio-agents or particulates, from a surface. The device vibrates a region of a target surface containing the sample and collects the sample on an electrically charged pin array. The sample can be later released to a detector or other instrumentation for subsequent analysis.

Abstract: A system for conducting a polymerase chain reaction (PCR) assay upon a collection of samples is disclosed. The PCR assay is performed by absorption detection. The system includes a multi-well plate which is adapted to retain a collection of sample wells. This system includes a thermal cycler for the multi-well plate. The system additionally includes a collection of photodetectors, and a corresponding number of light sources. The light sources are positioned such that light emitted from each of the respective light sources passes through a corresponding well retained in the multi-well plate and to a corresponding photodetector. The system also includes a processor or other means for analyzing the output signals from the photodetectors. In certain versions of the system, ultra-violet light is used.

Abstract: A technique for forming conjugates of proteins and oligonucleotides is disclosed in which conjugation is performed while the oligonucleotide is attached to support media such as glass beads. The conjugated product may then be readily removed from the support media. Also disclosed are the conjugated products formed by this technique. The present invention is particularly directed to conjugates of albumin proteins and specifically to bovine serum albumin (BSA).

Abstract: An electrophoretic cell configuration and related method are disclosed that employ oppositely directed traveling electrical waves. The waves travel across the cell and samples undergoing separation. Various strategies are used to selectively direct the movement and arrangement of the samples and resulting sample patterns.

Abstract: Various gel electrophoretic assemblies and techniques are disclosed for providing unique isoelectric focusing (IEF) strategies. Several particular systems, assemblies and methods are provided that significantly reduce processing time, enable the use of reduced operating voltages, and produce analytical results with improved resolution.

Abstract: Various traveling wave grids and electrophoretic systems, and electrode assemblies using such grids, are disclosed. A configuration in which a voltage potential is used to load a biomolecule sample against a grid is disclosed. A unique strategy of using multiple, reconfigurable grids in such systems is also described. The strategy involves initially conducting a broad protein separation and then selectively tailoring one or more grids, and conducting one or more secondary processing operations. Related strategies and specific methods are additionally disclosed for separating samples of biomolecules and components thereof using the noted systems, assemblies, and grids.

Abstract: The invention provides devices for analyzing genetic material comprising a substrate and a first genetic material position and a second genetic material position on the substrate that each comprise genetic material attached to the substrate. The invention also provides methods of distributing genetic material comprising distributing at least one device.

Abstract: A technique for forming conjugates of proteins and oligonucleotides is disclosed in which conjugation is performed while the oligonucleotide is attached to support media such as glass beads. The conjugated product may then be readily removed from the support media. Also disclosed are the conjugated products formed by this technique. The present invention is particularly directed to conjugates of albumin proteins and specifically to bovine serum albumin (BSA).

Abstract: The invention provides devices for analyzing genetic material comprising a substrate and a first genetic material position and a second genetic material position on the substrate that each comprise genetic material attached to the substrate. The invention also provides methods of distributing genetic material comprising distributing at least one device.