Patents by Inventor Ben James Mellor

Ben James Mellor has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Process for the preparation of phosphorothioate oligonucleotides
    Patent number: 7227017
    Abstract: A process for the synthesis of phosphorothioate oligonucleotides is provided which comprises assembling an oligonucleotide bound to a solid support in the presence of acetonitrile; prior to cleaving the oligonucleotide from the solid support removing the acetonitrile; and cleaving the oligonucleotide from the solid support. The process is particularly suited to the large scale synthesis of nucleotides. The acetonitrile may be removed from the solid support by one or both of drying and by washing with solvents. Preferred washing solvents comprise trialkylamines.
    Type: Grant
    Filed: June 5, 2003
    Date of Patent: June 5, 2007
    Assignee: Avecia Limited
    Inventors: Ben James Mellor, Donald Alfred Wellings, Mark Edward Douglas
  • Process
    Patent number: 6768005
    Abstract: A process for the synthesis of phosphorothioate oligonucleotides is provided which comprises assembling an oligonucleotide bound to a solid support in the presence of acetonitrile; prior to cleaving the oligonucleotide from the solid support removing the acetonitrile; and cleaving the oligonucleotide from the solid support. The process is particularly suited to the large scale synthesis of nucleotides.
    Type: Grant
    Filed: December 20, 2000
    Date of Patent: July 27, 2004
    Assignee: Avecia Limited
    Inventors: Ben James Mellor, Donald Alfred Wellings, Mark Edward Douglas
  • Process for the preparation of phosphorothioate oligonucleotides
    Publication number: 20030229221
    Abstract: A process for the synthesis of phosphorothioate oligonucleotides is provided which comprises assembling an oligonucleotide bound to a solid support in the presence of acetonitrile; prior to cleaving the oligonucleotide from the solid support removing the acetonitrile; and cleaving the oligonucleotide from the solid support. The process is particularly suited to the large scale synthesis of nucleotides. The acetonitrile may be removed from the solid support by one or both of drying and by washing with solvents. Preferred washing solvents comprise trialkylamines.
    Type: Application
    Filed: June 5, 2003
    Publication date: December 11, 2003
    Applicant: AVECIA LIMITED
    Inventors: Ben James Mellor, Donald Alfred Wellings, Mark Edward Douglas
  • Transfer hydrogenation process and catalyst
    Patent number: 6545188
    Abstract: A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal cyclopentadienyl complex which is coordinated to defined bidentate ligands. Preferred metals include rhodium, ruthenium and iridium. Preferred bidentate ligands are diamines and aminoalcohols, particularly those comprising chiral centers. The hydrogen donor is advantageously a secondary alcohol or a mixture of triethylamine and formic acid. The process can be employed to transfer hydrogenate ketones and imines, which are preferably prochiral. Catalysts for use in such a process are also provided.
    Type: Grant
    Filed: February 27, 2002
    Date of Patent: April 8, 2003
    Assignee: Avecia Limited
    Inventors: Andrew John Blacker, Ben James Mellor
  • Transfer hydrogenation process and catalyst
    Publication number: 20020156282
    Abstract: A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal cyclopentadienyl complex which is coordinated to defined bidentate ligands. Preferred metals include rhodium, ruthenium and iridium. Preferred bidentate ligands are diamines and aminoalcohols, particularly those comprising chiral centers. The hydrogen donor is advantageously a secondary alcohol or a mixture of triethylamine and formic acid. The process can be employed to transfer hydrogenate ketones and imines, which are preferably prochiral. Catalysts for use in such a process are also provided.
    Type: Application
    Filed: February 27, 2002
    Publication date: October 24, 2002
    Applicant: Avecia Limited
    Inventors: Andrew John Blacker, Ben James Mellor
  • Process
    Publication number: 20020111479
    Abstract: A process for the synthesis of phosphorothioate oligonucleotides is provided which comprises assembling an oligonucleotide bound to a solid support in the presence of acetonitrile; prior to cleaving the oligonucleotide from the solid support removing the acetonitrile; and cleaving the oligonucleotide from the solid support. The process is particularly suited to the large scale synthesis of nucleotides.
    Type: Application
    Filed: December 20, 2000
    Publication date: August 15, 2002
    Inventors: Ben James Mellor, Donald Alfred Wellings, Mark Edward Douglas
  • Transfer hydrogenation process and catalyst
    Patent number: 6372931
    Abstract: A catalytic transfer hydrogenation process is provided. The catalyst employed in the process is a metal cyclopentadienyl complex which is coordinated to defined bidentate ligands. Preferred metals include rhodium, ruthenium and iridium. Preferred bidentate ligands are diamines and aminoalcohols, particularly those comprising chiral centers. The hydrogen donor is advantageously a secondary alcohol or a mixture of triethylamine and formic acid. The process can be employed to transfer hydrogenate ketones and imines, which are preferably prochiral. Catalysts for use in such a process are also provided.
    Type: Grant
    Filed: November 9, 1999
    Date of Patent: April 16, 2002
    Assignee: Avecia Limited
    Inventors: Andrew John Blacker, Ben James Mellor