Abstract: Disclosed are compounds of Formula 1, stereoisomers thereof, and pharmaceutically acceptable salts thereof, wherein L, r, s, R5, R6, R7, R9, R10, R11, R12, X1, X2, X3, X4, X13, and X14 are defined in the specification. This disclosure also relates to materials and methods for preparing compounds of Formula 1, to pharmaceutical compositions which contain them, and to their use for treating diseases, disorders, and conditions associated with SSTR4.

Abstract: For processing call center data, an access module receives call system data for a plurality of users. The access module further receives customer relationship management (CRM) data and receives user data for the plurality of users. A display module displays the call system data, the CRM data, and the user data in a temporal relationship for a first user as dashboard data.

Abstract: A method includes receiving a first signal and updating a bitmap index responsive to the first signal. The bitmap index includes a plurality of bit strings, where a value stored in a particular location in each of the bit strings indicates whether a corresponding signal associated with a signal source has been received. Updating the bitmap index responsive to the first signal includes updating a first bit of the bitmap index and updating first metadata values stored in the bitmap index, wherein the first metadata values comprise a plurality of sort index values indicating relative ranks of the first bit string relative to other bit strings. The method also includes outputting query results based on a query, wherein the query results identify one or more signals associated with one or more bit strings of the plurality of bit strings and one or more signal sources of a plurality of signal sources, and wherein the query results are sorted according to one of the first metadata values.

Abstract: A method includes receiving a first signal and updating a bitmap index responsive to the first signal. The bitmap index includes a plurality of bit strings, where a value stored in a particular location in each of the bit strings indicates whether a corresponding signal associated with a signal source has been received. Updating the bitmap index responsive to the first signal includes updating a first bit of the bitmap index and updating a first metadata value stored in the bitmap index. The method also includes receiving a second signal and updating the bitmap index responsive to the second signal. Updating the bitmap index responsive to the second signal includes updating a second bit of the bitmap index and updating a second metadata value stored in the bitmap index.

Abstract: A method includes receiving a first signal and updating a bitmap index responsive to the first signal. The bitmap index includes a plurality of bit strings, where a value stored in a particular location in each of the bit strings indicates whether a corresponding signal associated with a signal source has been received. Updating the bitmap index responsive to the first signal includes updating a first bit of the bitmap index and updating a first metadata value stored in the bitmap index. The method also includes receiving a second signal and updating the bitmap index responsive to the second signal. Updating the bitmap index responsive to the second signal includes updating a second bit of the bitmap index and updating a second metadata value stored in the bitmap index.

Abstract: A method includes receiving a query directed to a bitmap index. The bitmap index includes a plurality of bit strings, where a value stored in a particular location in each of the bit strings indicates whether a corresponding signal associated with a signal source has been received, and where the bitmap index includes at least a first metadata value associated with each of the bit strings, at least a second metadata value associated with each of a plurality of signal sources, or both. The method also includes generating a query execution plan for the query and generating query results based on the query execution plan. The query results identify at least one signal associated with at least one bit string of the plurality of bit strings, at least one signal source of the plurality of signal sources, and at least one of the first metadata value or the second metadata value.

Abstract: Systems and methods of manipulating discrete volumes of a first fluid in a second fluid are provided. In some embodiments, discrete volumes can be formed in a conduit. In other embodiments, addition fluid can be added to a discrete volume in a first conduit by injecting the addition fluid at a relatively higher pressure. In some embodiments, discrete volumes that normally would not coalesce can be manipulated to be merged together.

Abstract: A high-resolution music application is disclosed and comprises: a) a high resolution audio file, b) an executable application that is compatible with the high resolution audio file, and c) a device that contains both the high resolution audio file and the executable application, wherein the device comprises at least one speaker, at least one control system, at least one headphone or earbud port or a combination thereof. In addition, a high-resolution multi-media application is disclosed that comprises: a) at least one high resolution file, b) an executable application that is compatible with the at least one high resolution file, and c) a device that contains both the at least one high resolution audio file and the executable application, wherein the device comprises at least one speaker, at least one control system, at least one headphone or earbud port or a combination thereof.

Abstract: A polyelectrolyte-coated particle, devices for using the particle, methods for using the particle for separating PCR reaction products and/or DNA sequencing reaction products, and compositions for coating the particle are provided.

Abstract: Systems and methods for compiling and analyzing bids from bidders in an auction offering of securities by an issuing company are disclosed. A data striper stripes bid data compiled from the bids of potential investors into a plurality of stripes according to an algorithm and a bid aggregation system aggregates the bid data in the stripes. The bid aggregation system may perform a first-level aggregation on the bid data in the data stripes for combinations of a plurality of attributes related to the bid data and/or a second-level aggregation based on the first-level aggregation. The auction management system may further comprise an analytics system for analyzing the aggregated bid data. The analytics system may receive user requests for analysis of the bid data, perform the analysis in real time based on the user inputs, and serve the results of the analysis to the user.

Abstract: An exemplary method correlates a steering device position to a steered element position by determining a target steering angle based on a detected position of the steering device; determining a vehicle steering angle based on a detected position of the steered element; determining a steering correction based on comparing the target steering angle to the vehicle steering angle; and applying a steering control multiplier to affect the steering correction in response to a difference between the target steering angle and the vehicle steering angle being larger than a threshold difference, and in response to a detected vehicle parameter.

Abstract: A two-way vehicle communication system has been developed that includes at least one vehicle, at least one vehicle data collection point, at least one operations data supply system, and at least one data communication system, wherein the data communication system is operatively coupled to the at least one vehicle, the at least one vehicle data collection point, the at least one operations data supply system or a combination thereof. A method of monitoring a vehicle using a two-way vehicle communication system has been developed that includes: providing at least one vehicle, providing at least one vehicle data collection point, providing at least one operations data supply system, and providing at least one data communication system, wherein the data communication system is operatively coupled to and communicates with the at least one vehicle, the at least one vehicle data collection point, the at least one operations data supply system or a combination thereof.

Abstract: Systems and methods of selling employee stock options (ESOs) and other compensation instruments. The method may comprise receiving a sale order for the employee stock options from a seller. The method may also comprise the step of determining a winning bidder based on bids submitted by at least two bidders that specify a price for the employee stock options. The method may further comprise suspending the auction until there are qualifying bids from at least two bidders. The method may also comprise transferring a derivative in place of the employee stock options to the winning bidder, wherein the derivative entities the holder thereof to buy a quantity of securities of an issuer at the price.

Abstract: A two-way vehicle communication system has been developed that includes at least one vehicle, at least one vehicle data collection point, at least one operations data supply system, and at least one data communication system, wherein the data communication system is operatively coupled to the at least one vehicle, the at least one vehicle data collection point, the at least one operations data supply system or a combination thereof. A method of monitoring a vehicle using a two-way vehicle communication system has been developed that includes: providing at least one vehicle, providing at least one vehicle data collection point, providing at least one operations data supply system, and providing at least one data communication system, wherein the data communication system is operatively coupled to and communicates with the at least one vehicle, the at least one vehicle data collection point, the at least one operations data supply system or a combination thereof.

Abstract: A high-resolution music application is disclosed and comprises: a) a high resolution audio file, b) an executable application that is compatible with the high resolution audio file, and c) a device that contains both the high resolution audio file and the executable application, wherein the device comprises at least one speaker, at least one control system, at least one headphone or earbud port or a combination thereof. In addition, a high-resolution multi-media application is disclosed that comprises: a) at least one high resolution file, b) an executable application that is compatible with the at least one high resolution file, and c) a device that contains both the at least one high resolution audio file and the executable application, wherein the device comprises at least one speaker, at least one control system, at least one headphone or earbud port or a combination thereof.

Abstract: Systems and methods of selling employee stock options (ESOs) and other compensation instruments. The method may comprise the steps of receiving a sale order for the employee stock options from a seller, where the sale order indicates the price of the employee stock options to be sold and the number of employee stock options to be sold. The method may also comprise the step of determining a winning bidder, from the at least two bidders, of an auction for the employee stock options based on bids submitted by the at least two bidders that specify a price for the employee stock options. The method may further comprise suspending the auction until there are qualifying bids from at least two bidders. The method may also comprise transferring a derivative in place of the employee stock options to the winning bidder, wherein the derivative entitles the holder thereof to buy a quantity of securities of an issuer at the price.

Abstract: A polyelectrolyte-coated particle, devices for using the particle, methods for using the particle for separating PCR reaction products and/or DNA sequencing reaction products, and compositions for coating the particle are provided.