Abstract: While one type of input, either a mouse input or a joystick input, may be preferred for one type of a game, it may not be preferred, or even compatible, for another type of a game. Introduced herein is a game controller that employs a dedicated input, which is capable of the absolute accuracy of a mouse input or trackball input, but is also capable of measuring how far off center the input is (e.g., how far off center it has moved), and can also return to center when released, as is present in a joystick input. The introduced game controller integrates a touch sensing trackball to enjoy the benefits of both the mouse type input and joystick type input, in a single dedicated input, providing a user freedom to play any type of game without worrying about the compatibility of their game controllers.

Abstract: There is provided a method of differentiating between a strain and a contraction of the pelvic floor muscles (PFM) of a subject. The method comprises receiving data generated by an orientation sensor provided within a vaginal probe device that is located within the vaginal canal of the subject; utilizing a processor to process data generated by the orientation sensor to determine a direction of rotation of the vaginal probe device during a measurement period. When the processor determines that the vaginal probe device has rotated in the cranial-ventral direction relative to the subject, an output is generated indicating that there has been a contraction of the PFM during the measurement period; and when the processor determines that the vaginal probe device has rotated in the caudal-dorsal direction relative to the subject, an output is generated indicating that there has been a strain of the PFM during the measurement period.

Abstract: A method of differentiating between a strain and a contraction of the pelvic floor muscles (PFM) of a subject includes receiving data generated by an orientation sensor provided within a vaginal probe device that is located within the vaginal canal of the subject and utilizing a processor to process data generated by the orientation sensor to determine a direction of rotation of the vaginal probe device during a measurement period. When the processor determines that the vaginal probe device has rotated in the cranial-ventral direction relative to the subject, an output is generated indicating that there has been a contraction of the PFM during the measurement period; and when the processor determines that the vaginal probe device has rotated in the caudal-dorsal direction relative to the subject, an output is generated indicating that there has been a strain of the PFM during the measurement period.

Abstract: The present disclosure provides method and system determining an optimal set of operating parameters for desired clinical outcome. The method comprises to receive treatment or target skin data comprising skin characteristics associated with skin to be treated with an aesthetic treatment by the aesthetic skin treatment unit and preset operating parameters for performing the aesthetic treatment. Further, the treatment data is analyzed using plurality of trained models to predict plurality of sets of operating parameters for the aesthetic skin treatment unit to perform the aesthetic treatment. Using the plurality of sets of operating parameters, an optimal set of operating parameters is determined for performing the aesthetic treatment by the using the aesthetic skin treatment unit. By proposed system and method, accurate set of operation parameters may be predicted to achieve desired clinical outcomes, without human intervention.

Abstract: A method of differentiating between a strain and a contraction of the pelvic floor muscles (PFM) of a subject includes receiving data generated by an orientation sensor provided within a vaginal probe device that is located within the vaginal canal of the subject and utilizing a processor to process data generated by the orientation sensor to determine a direction of rotation of the vaginal probe device during a measurement period. When the processor determines that the vaginal probe device has rotated in the cranial-ventral direction relative to the subject, an output is generated indicating that there has been a contraction of the PFM during the measurement period; and when the processor determines that the vaginal probe device has rotated in the caudal-dorsal direction relative to the subject, an output is generated indicating that there has been a strain of the PFM during the measurement period.

Abstract: A method and apparatus for imaging a live cell object, the method including the steps of: (a) modulating the phase of an electromagnetic wave in a periodic pattern with a two dimensional phase grating to produce a phase modulated electromagnetic wave in two axes; (b) projecting a real image of the phase grating onto an object to produce phase modulated electromagnetic wave illumination of the object; (c) varying a location of the periodic pattern in time along the two axes to change the phase of the periodic pattern; (d) projecting a real image of the object to a detector; (e) recording multiple images of the object with the detector, each of the images is recorded with the periodic pattern in a different location; and (f) calculating a synthetic image of the object by extracting information 90 degrees out of phase with the illumination.

Abstract: An outdoor lighting device and method for achieving the same, the device including: (a) a light source; (b) a concentrator including only a first solid optical medium (SOM), the concentrator having an input surface optically coupled to the light source, a side surface and an output surface; and (c) a transparent cover optically coupled to the output surface, and covering substantially all of the output surface, wherein the side surface is shaped so as to provide a desired luminous intensity profile emerging from the transparent cover, and wherein a continuity from the light source to the transparent cover is uninterrupted by an air gap.

Abstract: A method for inspecting an object and an inspection system, the system includes: at least one primary light source followed by at least one illumination path imaging lens adapted to direct at least one primary light beam towards an area of an inspected object; at least one secondary light source followed by at least one collimating component and at least one concentrating component adapted to direct at least one secondary light beam towards the area; wherein the at least one primary light beam and the at least one secondary light beam illuminate the area such that substantially each point within an imaged portion of the area is illuminated over a large angular range characterized by substantially uniform intensity; a collection path that comprises an image sensor, a beam splitter path and a collection path imaging lens; wherein the beam splitter is positioned between the area and between the collection path imaging lens; and wherein the at least one collimating component defines a central aperture through whi

Abstract: A device and method for directing light from a non directed light source into a forward direction with a required angular distribution. The device may comprise a tapered light guide, a front refractor and a back reflector. The wedge angle of the light guide is selected such that light incident upon the entrance of the light guide and exits the light guide and is directed either by the front refractor or the back reflector into the desired angular distribution.

Abstract: A method for inspecting an object and an inspection system, the system includes: at least one primary light source followed by at least one illumination path imaging lens adapted to direct at least one primary light beam towards an area of an inspected object; at least one secondary light source followed by at least one collimating component and at least one concentrating component adapted to direct at least one secondary light beam towards the area; wherein the at least one primary light beam and the at least one secondary light beam illuminate the area such that substantially each point within an imaged portion of the area is illuminated over a large angular range characterized by substantially uniform intensity; a collection path that comprises an image sensor, a beam splitter path and a collection path imaging lens; wherein the beam splitter is positioned between the area and between the collection path imaging lens; and wherein the at least one collimating component defines a central aperture through whi

Abstract: A patterned TDI sensor comprising an array of pixels having respective sensitivities to light that varies according to a periodic pattern across said array of pixels, for high throughput applications of imaging and measurement with patterned illumination such as structured illumination, Moire techniques, 3D imaging and 3D metrology. An object is measured by scanning the object with illumination that varies periodically across the object, imaging the object with a patterned TDI sensor having a repetition length matched with the repetition length of the illumination and analyzing the output signal of the TDI sensor to extract information such as height or image of the object.

Abstract: The present invention provides antibodies or fragments thereof that bind to cancer cells and is important in physiological phenomena, such as cell rolling and metastasis. Therapeutic and diagnostic methods and compositions using such antibody fragments thereof are also provided. The methods and compositions according to the present invention can be used in targeting therapeutic agents and in diagnosis, prognosis, and staging of and therapy for such diseases as cancer, including tumor growth and metastasis, leukemia, auto-immune disease, and inflammatory disease. Also provided is a library of immunoglobulin binding domains having a diverse antigen-binding domain for complementary binding, wherein the library has diversity only in heavy chain CDR3.

Abstract: The present invention provides antibodies or fragments thereof that bind to co-receptor CCR5 or CXCR4.

Abstract: Methods, systems, and apparatus for improved trading of financial interests via a computer network are disclosed. Improvements include crossing or commingling of auction and non-auction transaction proposals; disclosure of high bids and of identify of high bidders and offerors during the auction process; presentation of reference benchmark prices and benchmark-derived price references; immediate rescission of multiple proposed transactions in case of emergency; time-limited passwords; assignment of user access level classes; keyword tagging or identification of offers or bids; the use of multiple data sets or trading channels to enable separation of accounting and to accommodate training and familiarization efforts; enabling the creation of data sets in outside programs and subsequent and optionally repeated uploading or importation of data to the auction system; and staging of transactions for supervisory review.

Abstract: Methods for creating and maintaining stock value chains. One embodiment comprises the steps of receiving a stock symbol, creating a value chain for the stock symbol, and returning the value chain of the stock symbol.

Abstract: A method comprising the steps of calculating a large amount of investment strategies for predefined stocks; finding a predefined number of investment strategies, which feature the best calculated rating results for each type of rating; calculating a weighted evaluation score for each of the strategies; and forwarding to an end-user application a predefined number of the calculated strategies according to a predefined criterion.

Abstract: A method comprising the steps of supplying an interactive environment through which a plurality of financial system users can express their sentiment towards a predefined stock, analyzing the users' sentiment expressions in order to deduce the users' sentiment towards the predefined stock and supplying the deduced users' sentiment towards the predefined stock.

Abstract: The present invention provides antibodies or fragments thereof that bind to co-receptor CCR5 or CXCR4.

Abstract: The present invention provides antibodies that bind an epitope of PSGL-1 comprising the motif D-X-Y-D, wherein X represents any amino acid or the covalent linkage between D and Y, and Y is sulfated, which antibody can be complexed with one or more copies of an agent. The antibodies of the invention can be used in a method of inducing antibody-dependent cell cytotoxicity and/or stimulating natural killer (NK) cells or T cells. In addition, by administering these antibodies to a patient in need thereof, a method of inducing cell death is provided. A method of preventing infection by a virus (e.g., HIV) by administering to a patient in need thereof an antibody of the present invention is also provided. The, present invention also provides a method of introducing an agent into a cell that expresses sulfated PSGL-1 by coupling or complexing an agent to an antibody of the present invention and administering the complex to the cell.

Abstract: The present invention provides antibodies or fragments thereof that bind to cancer cells and is important in physiological phenomena, such as cell rolling and metastasis. Therapeutic and diagnostic methods and compositions using such antibody fragments thereof are also provided. The methods and compositions according to the present invention can be used in targeting therapeutic agents and in diagnosis, prognosis, and staging of and therapy for such diseases as cancer, including tumor growth and metastasis, leukemia, auto-immune disease, and inflammatory disease. Also provided is a library of immunoglobulin binding domains having a diverse antigen-binding domain for complementary binding, wherein the library has diversity only in heavy chain CDR3.