Patents by Inventor Ben McNally
Ben McNally has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11821032Abstract: The present invention provides methods, compositions, mixtures and kits utilizing 5-Chloro-2-methyl-4-isothiazolin-3-one in sequencing reactions, and in particular, sequencing reactions where deoxynucleoside triphosphates comprising a 3?-O position capped by a disulfide-based 3?-terminator group are used. In one embodiment, the deoxynucleoside triphosphates comprise a 3?-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. In addition, thiol-containing compounds and scavengers of thio-containing compounds are described. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.Type: GrantFiled: August 21, 2020Date of Patent: November 21, 2023Assignee: IsoPlexis CorporationInventors: Luisa Andruzzi, Jimmy Adediran, Timothy Pelletier, Austin Ricker, Angela DeLucia, Ben McNally, Dona Hevroni, Mong Sano Marma, John Andrew Sheridan
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Publication number: 20230340583Abstract: The present invention provides methods, compositions, mixtures and kits utilizing 5-Chloro-2-methyl-4-isothiazolin-3-one in sequencing reactions, and in particular, sequencing reactions where deoxynucleoside triphosphates comprising a 3?-O position capped by a disulfide-based 3?-terminator group are used. In one embodiment, the deoxynucleoside triphosphates comprise a 3?-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. In addition, thiol-containing compounds and scavengers of thio-containing compounds are described. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.Type: ApplicationFiled: April 6, 2023Publication date: October 26, 2023Inventors: Luisa ANDRUZZI, Jimmy ADEDIRAN, Timothy PELLETIER, Austin RICKER, Angela DELUCIA, Ben MCNALLY, Dona HEVRONI, Mong Sano MARMA, John Andrew SHERIDAN
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Publication number: 20220315995Abstract: The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3?-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. In addition, thiol-containing compounds and scavengers of thio-containing compounds are described. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.Type: ApplicationFiled: February 3, 2022Publication date: October 6, 2022Inventors: Mong Sano MARMA, Luisa ANDRUZZI, Ben MCNALLY, Angela DELUCIA, Dona HEVRONI, Elizabeth CARPENTER, Magnus BESEV
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Patent number: 11421264Abstract: The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3?-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. In addition, thiol-containing compounds and scavengers of thio-containing compounds are described. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.Type: GrantFiled: March 13, 2017Date of Patent: August 23, 2022Assignee: IsoPlexis CorporationInventors: Mong Sano Marma, Luisa Andruzzi, Ben McNally, Angela DeLucia, Dona Hevroni, Elizabeth Carpenter, Magnus Besev
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Publication number: 20210002720Abstract: The present invention provides methods, compositions, mixtures and kits utilizing 5-Chloro-2-methyl-4-isothiazolin-3-one in sequencing reactions, and in particular, sequencing reactions where deoxynucleoside triphosphates comprising a 3?-O position capped by a disulfide-based 3?-terminator group are used. In one embodiment, the deoxynucleoside triphosphates comprise a 3?-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. In addition, thiol-containing compounds and scavengers of thio-containing compounds are described. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.Type: ApplicationFiled: August 21, 2020Publication date: January 7, 2021Inventors: Luisa Andruzzi, Jimmy Adediran, Timothy Pelletier, Austin Ricker, Angela DeLucia, Ben McNally, Dona Hevroni, Mong Sano Marma, John Andrew Sheridan
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Patent number: 10844430Abstract: The present invention provides methods, compositions, mixtures and kits utilizing 5-Chloro-2-methyl-4-isothiazolin-3-one in sequencing reactions, and in particular, sequencing reactions where deoxynucleoside triphosphates comprising a 3?-O position capped by a disulfide-based 3?-terminator group are used. In one embodiment, the deoxynucleoside triphosphates comprise a 3?-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. In addition, thiol-containing compounds and scavengers of thio-containing compounds are described. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.Type: GrantFiled: January 24, 2018Date of Patent: November 24, 2020Assignee: Qiagen Sciences, LLCInventors: Luisa Andruzzi, Jimmy Adediran, Timothy Pelletier, Austin Ricker, Angela DeLucia, Ben McNally, Dona Hevroni, Mong Sano Marma, John Andrew Sheridan
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Publication number: 20190226018Abstract: The present invention provides methods, compositions, mixtures and kits utilizing 5-Chloro-2-methyl-4-isothiazolin-3-one in sequencing reactions, and in particular, sequencing reactions where deoxynucleoside triphosphates comprising a 3?-O position capped by a disulfide-based 3?-terminator group are used. In one embodiment, the deoxynucleoside triphosphates comprise a 3?-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. In addition, thiol-containing compounds and scavengers of thio-containing compounds are described. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.Type: ApplicationFiled: January 24, 2018Publication date: July 25, 2019Inventors: Luisa Andruzzi, Jimmy Adediran, Timothy Pelletier, Austin Ricker, Angela DeLucia, Ben McNally, Dona Hevroni, Mong Sano Marma, John Andrew Sheridan
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Publication number: 20180127819Abstract: The invention relates to methods, compositions, devices, systems and kits as described including, without limitation, reagents and mixtures for determining the identity of nucleic acids in nucleotide sequences using, for example, sequencing by synthesis (SBS) methods. In particular, the present invention contemplates the use of chelators in washing reagents to improve SBS performance.Type: ApplicationFiled: October 31, 2017Publication date: May 10, 2018Inventors: Luisa Andruzzi, Ben McNally, Angela DeLucia, Dona Hevroni
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Publication number: 20170211134Abstract: The present invention provides methods, compositions, mixtures and kits utilizing deoxynucleoside triphosphates comprising a 3?-O position capped by a group comprising methylenedisulfide as a cleavable protecting group and a detectable label reversibly connected to the nucleobase of said deoxynucleoside. In addition, thiol-containing compounds and scavengers of thio-containing compounds are described. Such compounds provide new possibilities for future sequencing technologies, including but not limited to Sequencing by Synthesis.Type: ApplicationFiled: March 13, 2017Publication date: July 27, 2017Inventors: Mong Sano Marma, Luisa Andruzzi, Ben MCNally, Angela DeLucia, Dona Hevroni, Elizabeth Carpenter, Magnus Besev
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Patent number: 7336844Abstract: A method of deblurring images e.g. from an MRI scan, comprises calculating the distribution of the slope value of the intensities between the pixels in the image, and using a Levy distribution of power factor k of 1 (Cauchy distribution) up to but not including (2) to determine the correction term to be applied.Type: GrantFiled: July 11, 2001Date of Patent: February 26, 2008Inventors: Edward Roy Pike, Deeph Chana, Ben McNally
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Publication number: 20040066959Abstract: A method of deblurring images e.g. from an MRI scan, comprises calculating the distribution of the slope value of the intensifies between the Levy distribution of power factor k of 1 (Cauchy distribution) up to but not including (2) to determine the correction term to be applied.Type: ApplicationFiled: October 3, 2003Publication date: April 8, 2004Inventors: Edward Roy Pike, Deeph Chana, Ben McNally