Abstract: Systems and methods for transferring multi-frame data to remote computing entities. Systems including dedicated communications for multi-frame data and other data, and data transfer methods. An example computer-implemented method includes receiving, at an agent module positioned at a primary location, multi-frame medical image data over an intranet data connection from an image acquisition device also positioned at the primary location, compressing at the agent module the multi-frame medical image data, sending the compressed data from the agent module to a server over a first data transmission via an Internet data connection, storing the compressed data at the server, sending the compressed data to a user terminal device, and receiving medical data at the server from one or more computing devices positioned at the primary location over a second data transmission via the Internet data connection.