Abstract: Disclosed is a system that includes a CNN is configured to predict an output for each input, and generate an FMCM for each input, thereby generating a plurality of training FMCMs for a plurality of training inputs that has been used to train the CNN, and form a training feature map covariance space based on the plurality of training FMCMs. The system further includes an out of domain classifier built based on the training feature map covariance space, and configured to run on a new input to classify the new input in or out of domain of the CNN, based on whether corresponding new FMCM is in or out of the training feature map covariance space.

Abstract: A system and associated method for manipulating tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders or other purposes. In one aspect, the system includes a delivery device and a plurality of anchor assemblies. The delivery system is configured to deliver a first anchor using loaded energy and reload the energy required to deliver an addition anchor.

Abstract: A method for obtaining verification data, the method comprises receiving generated data from a data source; calculating a hash value for the generated data; transmitting the hash value to a verification service provider; receiving verification data from the verification service provider; and storing the generated data and the verification data

Abstract: In general, embodiments of the present invention provide methods, apparatus, systems, computing devices, computing entities, and/or the like for pipelined machine learning. Certain embodiments of the present invention utilize systems, methods, and computer program products that perform pipelined machine learning using at least one of error correction machine learning models and output augmentation machine learning models, for example using a pipelined implementation of error correction machine learning models followed by output augmentation machine learning models.

Abstract: A method for measuring the degree of aggregation of a protein or a polypeptide in a liquid sample, the method comprising the steps of combining an amount of a fluorophore molecule with the aggregated protein or polypeptide in the liquid sample; and measuring the fluorescence polarization value of the combination to determine the degree of aggregation: wherein the fluorophore molecule is a diazaoxatriangulenium of Formula (I) or a derivative thereof.

Abstract: A cell culture media comprising an effective amount of 3-Thiopheneacetic acid (3TAA).

Abstract: The present invention particularly relates to a system and method using a convolutional neural network such as a U-net convolutional neural network to reconstruct microscopy images, for example phase contrast microscopy images. The method as per the present invention comprises the steps of obtaining a training data set comprising of a plurality of brightfield microscopy images and a plurality of phase contrast microscopy images, training a neural network based on the data set to extract phase information in the form of an interference pattern from each of the plurality of brightfield microscopy images and to further use the trained neural network to reconstruct phase contrast microscopy images from the brightfield microscopy images. The system as per the present invention comprises a memory means, a processing means, a storage and retrieval means, and a display means.

Abstract: A system and associated method for altering or destroying tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders. In one aspect, the system includes a device configured to deploy devices for altering the lobes of a prostate.

Abstract: A system and method for stimulus & eye tracking, useful for the determination of the presence or strength of optokinetic nystagmus (OKN) typically for assessing visual acuity, comprises providing a novel visual stimulus effective to elicit OKN, which includes varying the visibility of a visual stimulus element, or displaying a series of visual stimulus elements so that a later displayed element has different visibility relative to an earlier displayed element. Visual stimulus elements may vanish or appear by reducing or increasing intensity, contrast, size and/or width of the elements or element boundaries. Visual stimulus elements comprise a perimeter that is darker than a background and a centre that is lighter than the background, and/or a perimeter that is lighter than a background and a centre that is darker than the background.

Abstract: A system and associated method for manipulating tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders or other purposes. In one aspect, the system includes a delivery device and a plurality of anchor assemblies. The delivery system is configured to deliver a first anchor using loaded energy and reload the energy required to deliver an addition anchor.

Abstract: A system and associated method for manipulating tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders or other purposes. In one aspect, the system includes a delivery device and a plurality of anchor assemblies. The delivery system is configured to deliver a first anchor using loaded energy and reload the energy required to deliver an addition anchor.

Abstract: A method of determining variation between a query cell culture media and a reference cell culture media is provided. The method comprises the steps of incubating a reference cell with an aliquot of the query culture media and at least three chemical cell stressors in wells of a microtitre plate and determining an environmental response of the reference cell in the presence of the query cell culture media and each of the plurality of chemical cell stressors. A query cell culture media specific environmental response fingerprint is generated comprising the plurality of chemical cell stressor specific environmental responses. The query cell culture media-specific environmental response fingerprint is compared with a reference media-specific environmental response fingerprints corresponding to a reference cell culture media and generated using the reference cell.

Abstract: A method for predicting the phenotypic stability of a cell line comprises the steps of culturing the cell line over an assay period, and generating an environmental response fingerprint for the cell line at a plurality of different time points over the assay period, wherein each environmental response fingerprint is generated by determining the environmental response of the cells in the presence of each of a plurality of chemical cell stressors. The plurality of environmental response fingerprints are compared to detect change in the environmental response fingerprint over the assay period. The level of change in the environmental response fingerprint over the assay period is indicative of the level of predicted phenotypic instability in the cell line. The environmental response may be growth response, productivity response, or another detectable environmental response.

Abstract: A system and method for stimulus & eye tracking, useful for the determination of the presence or strength of optokinetic nystagmus (OKN) typically for assessing visual acuity, comprises providing a novel visual stimulus effective to elicit OKN, which includes varying the visibility of a visual stimulus element, or displaying a series of visual stimulus elements so that a later displayed element has different visibility relative to an earlier displayed element. Visual stimulus elements may vanish or appear by reducing or increasing intensity, contrast, size and/or width of the elements or element boundaries. Visual stimulus elements comprise a perimeter that is darker than a background and a centre that is lighter than the background, and/or a perimeter that is lighter than a background and a centre that is darker than the background.

Abstract: Embodiments of the invention relate to a method of extracting eye velocity information from a video footage having a plurality of frames, comprising detecting at least part of an eye in at least two frames of the video footage, applying an optical flow algorithm to the at least two frames of the video footage to extract pixel velocity information, and determining a statistical measure from the pixel velocity information within the detected at least part of the eye. Other embodiments of the invention relate to a method of extracting head image trajectory information from a video footage having a plurality of frames, comprising detecting at least part of a facial region of the head image in at least two frames of the video footage, determining a measure of the movement of the at least part of a facial region between the at least two frames, and determining a transformation map from the measure of the movement.

Abstract: A system and associated method for altering or destroying tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders. In one aspect, the system includes a device configured to deploy devices for altering the lobes of a prostate.

Abstract: Embodiments of the invention relate to a method of extracting eye velocity information from a video footage having a plurality of frames, comprising detecting at least part of an eye in at least two frames of the video footage, applying an optical flow algorithm to the at least two frames of the video footage to extract pixel velocity information, and determining a statistical measure from the pixel velocity information within the detected at least part of the eye. Other embodiments of the invention relate to a method of extracting head image trajectory information from a video footage having a plurality of frames, comprising detecting at least part of a facial region of the head image in at least two frames of the video footage, determining a measure of the movement of the at least part of a facial region between the at least two frames, and determining a transformation map from the measure of the movement.

Abstract: A system and associated method for manipulating tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders or other purposes. In one aspect, the system includes a delivery device and a plurality of anchor assemblies. The delivery system is configured to deliver a first anchor using loaded energy and reload the energy required to deliver an addition anchor.

Abstract: A system and associated method for altering or destroying tissues and anatomical or other structures in medical applications for the purpose of treating diseases or disorders. In one aspect, the system includes a device configured to deploy devices for altering the lobes of a prostate.