Patents by Inventor Ben Turng
Ben Turng has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11840719Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.Type: GrantFiled: July 13, 2020Date of Patent: December 12, 2023Assignee: BECTON, DICKINSON AND COMPANYInventors: Mei Yang-Woytowitz, Brent Pohl, Gary F. Hershner, Dwight Livingston, Eric Ursprung, Gerard Lotz, Kevin Bailey, Ammon David Lentz, Michael A. Brasch, Ming-hsiung Yeh, Patrick Shawn Beaty, Charles C. Yu, Timothy M. Wiles, Liping Feng, Ben Turng, Xiaofei Chang, Patrick R. Murray
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Patent number: 11371072Abstract: An automated system for identifying in a biological sample microorganisms and their antimicrobial susceptibility (AST). The system provided an automated platform for preparing, from a single biological sample, inoculates for both ID and AST. The system loads a plate for ID testing as samples are being prepared for AST testing. The system tracks the sample and the inoculates from the samples to link the test results to the sample and the patients from whom the sample was obtained.Type: GrantFiled: April 5, 2019Date of Patent: June 28, 2022Assignee: BECTON DICKINSON AND COMPANYInventors: Robert Edward Armstrong, John Thulin Page, Ben Turng, Glen Richard Davis, Strett Roger Nicolson, Timothy Hansen
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Patent number: 11225681Abstract: Various embodiments disclosed herein provide for reagents and methods for rapidly isolating viable microbial cells, including S. pneumoniae, from positive blood culture samples. The resulting microbial pellet can be used for both identification and growth-based methods such as antimicrobial susceptibility testing. The buffers described herein may contain a base solution, non-ionic detergents, thiols, and optionally, ammonium chloride. The disclosed methods provide a process for rapidly isolating and concentrating viable microorganism(s) from PBC samples using only one sample preparation tube and centrifugation while removing cellular debris from the mammalian blood cells that may interfere with identification methods.Type: GrantFiled: November 7, 2019Date of Patent: January 18, 2022Assignee: BECTON, DICKINSON AND COMPANYInventors: Susan M. Kircher, Vanda White, William B. Brasso, Dyan Luper, James Y. Zhou, Julie L. Rosales, Jeffery H. Bruton, John D. Mantlo, Adrien P. Malick, Donald R. Callihan, Ben Turng, Liping Feng, Curtis M. Gosnell, Patrick Shawn Beaty, John P. Douglass
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Publication number: 20200340029Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.Type: ApplicationFiled: July 13, 2020Publication date: October 29, 2020Inventors: Mei Yang-Woytowitz, Brent Pohl, Gary F. Hershner, Dwight Livingston, Eric Ursprung, Gerard Lotz, Kevin Bailey, Ammon David Lentz, Michael A. Brasch, Ming-hsiung Yeh, Patrick Shawn Beaty, Charles C. Yu, Timothy M. Wiles, Liping Feng, Ben Turng, Xiaofei Chang, Patrick R. Murray
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Patent number: 10767146Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.Type: GrantFiled: October 24, 2014Date of Patent: September 8, 2020Assignee: BECTON, DICKINSON AND COMPANYInventors: Mei Yang-Woytowitz, Brent Pohl, Gary F. Hershner, Eric Ursprung, Michael A. Brasch, Ming-hsiung Yeh, Patrick Shawn Beaty, Charles C. Yu, Timothy M. Wiles, Liping Feng, Ben Turng, Xiaofei Chang, Patrick R. Murray
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Patent number: 10669566Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.Type: GrantFiled: June 13, 2018Date of Patent: June 2, 2020Assignee: Accelerate Giagnostics, Inc.Inventors: William L. Richards, Austin Ashby, Matthew Ketterer, Kevin Marshall, Josh Harrison, Matthew Mette, Paul Richards, Wayne Showalter, Jasmin Cote, Steven W. Metzger, Ken Hance, Meghan Mensack, Carlos Michel, Elke Allers, Dulini Gamage, Landon Prisbrey, Oleg Gusyatin, Alena Shamsheyeva, Ben Turng, Andrew Ghusson, Kurt Reinhardt, Phillip C. Halbert, Solene Bourgeois
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Publication number: 20200087702Abstract: Various embodiments disclosed herein provide for reagents and methods for rapidly isolating viable microbial cells, including S. pneumoniae, from positive blood culture samples. The resulting microbial pellet can be used for both identification and growth-based methods such as antimicrobial susceptibility testing. The buffers described herein may contain a base solution, non-ionic detergents, thiols, and optionally, ammonium chloride. The disclosed methods provide a process for rapidly isolating and concentrating viable microorganism(s) from PBC samples using only one sample preparation tube and centrifugation while removing cellular debris from the mammalian blood cells that may interfere with identification methods.Type: ApplicationFiled: November 7, 2019Publication date: March 19, 2020Applicant: BECTON DICKINSON AND COMPANYInventors: Susan M. Kircher, Vanda White, William B. Brasso, Dyan Luper, James Y. Zhou, Julie L. Rosales, Jeffery H. Bruton, John D. Mantlo, Adrien P. Malick, Donald R. Callihan, Ben Turng, Liping Feng, Curtis M. Gosnell, Patrick Shawn Beaty, John P. Douglass
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Patent number: 10519482Abstract: Various embodiments disclosed herein provide for reagents and methods for rapidly isolating viable microbial cells, including S. pneumoniae, from positive blood culture samples. The resulting microbial pellet can be used for both identification and growth-based methods such as antimicrobial susceptibility testing. The buffers described herein may contain a base solution, non-ionic detergents, thiols, and optionally, ammonium chloride. The disclosed methods provide a process for rapidly isolating and concentrating viable microorganism (s) from PBC samples using only one sample preparation tube and centrifugation while removing cellular debris from the mammalian blood cells that may interfere with identification methods.Type: GrantFiled: February 28, 2013Date of Patent: December 31, 2019Assignee: Becton, Dickinson And CompanyInventors: Susan M. Kircher, Vanda White, William B. Brasso, Dyan Luper, James Y. Zhou, Julie L. Rosales, Jeffery H. Bruton, John D. Mantlo, Adrien P. Malick, Donald R. Callihan, Ben Turng, Liping Feng, Curtis M. Gosnell, Patrick Shawn Beaty, John P. Douglass
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Publication number: 20190233873Abstract: An automated system for identifying in a biological sample microorganisms and their antimicrobial susceptibility (AST). The system provided an automated platform for preparing, from a single biological sample, inoculates for both ID and AST. The system loads a plate for ID testing as samples are being prepared for AST testing. The system tracks the sample and the inoculates from the samples to link the test results to the sample and the patients from whom the sample was obtained.Type: ApplicationFiled: April 5, 2019Publication date: August 1, 2019Inventors: Robert Edward Armstrong, John Thulin Page, Ben Turng, Glen Richard Davis, Strett Roger Nicolson, Timothy Hansen
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Patent number: 10294508Abstract: An automated system for identifying in a biological sample microorganisms and their antimicrobial susceptibility (AST). The system provided an automated platform for preparing, from a single biological sample, inoculates for both ID and AST. The system loads a plate for ID testing as samples are being prepared for AST testing. The system tracks the sample and the inoculates from the samples to link the test results to the sample and the patients from whom the sample was obtained.Type: GrantFiled: October 19, 2015Date of Patent: May 21, 2019Assignee: Becton, Dickinson and CompanyInventors: Robert Edward Armstrong, John Thulin Page, Ben Turng, Glen Richard Davis, Strett Roger Nicolson, Timothy Hansen
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Patent number: 10253355Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing. Automated quality control test components and methods of their use are also disclosed.Type: GrantFiled: October 3, 2016Date of Patent: April 9, 2019Assignee: Accelerate Diagnostics, Inc.Inventors: William L. Richards, Austin Ashby, Matthew Ketterer, Kevin Marshall, Josh Harrison, Matthew Mette, Paul Richards, Wayne Showalter, Jasmin Cote, Phillip C. Halbert, Solene Bourgeois, Steven W. Metzger, Ken Hance, Meghan Mensack, Carlos Michel, Elke Allers, Dulini Gamage, Landon Prisbrey, Oleg Gusyatin, Alena Shamsheyeva, Ben Turng, Andrew Ghusson, Kurt Reinhardt
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Publication number: 20180291419Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.Type: ApplicationFiled: June 13, 2018Publication date: October 11, 2018Applicant: Accelerate Diagnostics, Inc.Inventors: William L. Richards, Austin Ashby, Matthew Ketterer, Kevin Marshall, Josh Harrison, Matthew Mette, Paul Richards, Wayne Showalter, Jasmin Cote, Steven W. Metzger, Ken Hance, Meghan Mensack, Carlos Michel, Elke Allers, Dulini Gamage, Landon Prisbrey, Oleg Gusyatin, Alena Shamsheyeva, Ben Turng, Andrew Ghusson, Kurt Reinhardt, Phillip C. Halbert, Solene Bourgeois
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Patent number: 10023895Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.Type: GrantFiled: March 30, 2016Date of Patent: July 17, 2018Assignee: Accelerate Diagnostics, Inc.Inventors: William L. Richards, Austin Ashby, Matthew Ketterer, Kevin Marshall, Josh Harrison, Matthew Mette, Paul Richards, Wayne Showalter, Jasmin Cote, Phillip C. Halbert, Solene Bourgeois, Steven W. Metzger, Ken Hance, Meghan Mensack, Carlos Michel, Elke Allers, Dulini Gamage, Landon Prisbrey, Oleg Gusyatin, Alena Shamsheyeva, Ben Turng, Andrew Ghusson, Kurt Reinhardt
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Publication number: 20170204448Abstract: Rapid methods that identify sepsis-causing bacteria or yeast aid the physician in critical therapeutic decision-making, thus decreasing patient mortality rates. The methods described herein employ plating microorganisms directly on to a MALDI-MS plate, adding concentrated formic acid, and identifying the microorganism by mass spectrometry. Optionally, an organic solvent may be combined with the formic acid, or added to the sample before or after the concentrated formic acid is added thereto. The methods enable direct extraction of proteins from microorganisms without the need for liquid protein extraction methods and yields positive identification results for gram-positive bacteria, gram-negative bacteria and yeast in minutes.Type: ApplicationFiled: March 29, 2017Publication date: July 20, 2017Inventors: Liping Feng, William B. Brasso, Susan M. Kircher, Vanda White, Song Shi, Xiao Mo, Tuan-Linh Ngoc Nguyen, Adrien P. Malick, Jon E. Salomon, John D. Mantlo, Mary R. Votta, Ben Turng, Donald R. Callihan, Wendy Louise Williams
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Publication number: 20170023599Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing. Automated quality control test components and methods of their use are also disclosed.Type: ApplicationFiled: October 3, 2016Publication date: January 26, 2017Applicant: Accelerate Diagnostics, Inc.Inventors: William L. Richards, Austin Ashby, Matthew Ketterer, Kevin Marshall, Josh Harrison, Matthew Mette, Paul Richards, Wayne Showalter, Jasmin Cote, Phillip C. Halbert, Solene Bourgeois, Steven W. Metzger, Ken Hance, Meghan Mensack, Carlos Michel, Elke Allers, Dulini Gamage, Landon Prisbrey, Oleg Gusyatin, Alena Shamsheyeva, Ben Turng, Andrew Ghusson, Kurt Reinhardt
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Publication number: 20160289729Abstract: A system for automated microorganism identification and antibiotic susceptibility testing comprising a reagent cartridge, a reagent stage, a cassette, a cassette, stage, a pipettor assembly, an optical detection system, and a controller is disclosed. The system is designed to dynamically adjust motor idle torque to control heat load and employs a fast focus process for determining the true focus position of an individual microorganism. The system also may quantify the relative abundance of viable microorganisms in a sample using dynamic dilution, and facilitate growth of microorganisms in customized media for rapid, accurate antimicrobial susceptibility testing.Type: ApplicationFiled: March 30, 2016Publication date: October 6, 2016Applicant: Accelerate Diagnostics, Inc.Inventors: William L. Richards, Austin Ashby, Matthew Ketterer, Kevin Marshall, Josh Harrison, Matthew Mette, Paul Richards, Wayne Showalter, Jasmin Cote, Phillip C. Halbert, Solene Bourgeois, Steven W. Metzger, Ken Hance, Meghan Mensack, Carlos Michel, Elke Allers, Dulini Gamage, Landon Prisbrey, Oleg Gusyatin, Alena Shamsheyeva, Ben Turng, Andrew Ghusson, Kurt Reinhardt
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Publication number: 20160265022Abstract: An apparatus and associated methods of use for a controlled combination of reagents is disclosed. The apparatus includes a vessel 400, a vessel insert 220, and a cap element 200. The vessel 400 has a body portion 410 for receiving a biological sample. The vessel insert 220 receives at least one reagent therein. Preferably, the vessel insert 220 is received in a portion 420 of the vessel 400. The cap element 200 is attached to the vessel 400 to secure the vessel insert 220 in the vessel 400. During use, the vessel insert 220 is adapted to release its contents when the biological sample is introduced into the body portion 410 of the vessel 400 upon application of an intermixing force to the vessel insert 220. A variety of intermixing forces may be applied, depending upon the embodiment of the present invention and its associated methods of use.Type: ApplicationFiled: October 24, 2014Publication date: September 15, 2016Applicant: BECTON, DICKINSON AND COMPANYInventors: Mei Yang-Woytowitz, Brent Pohl, Gary F. Hershner, Dwight Livingston, Eric Ursprung, Gerard Lotz, Kevin Bailey, Ammon David Lentz, Michael A. Brasch, Ming-hsiung Yeh, Patrick Shawn Beaty, Charles C. Yu, Timothy M. Wiles, Liping Feng, Ben Turng, Xiaofei Chang, Patrick R. Murray
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Publication number: 20160040210Abstract: An automated system for identifying in a biological sample microorganisms and their antimicrobial susceptibility (AST). The system provided an automated platform for preparing, from a single biological sample, inoculates for both ID and AST. The system loads a plate for ID testing as samples are being prepared for AST testing. The system tracks the sample and the inoculates from the samples to link the test results to the sample and the patients from whom the sample was obtained.Type: ApplicationFiled: October 19, 2015Publication date: February 11, 2016Inventors: Robert Edward Armstrong, John Thulin Page, Ben Turng, Glen Richard Davis, Strett Roger Nicolson, Timothy Hansen
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Patent number: 9180448Abstract: An automated system for identifying in a biological sample microorganisms and their antimicrobial susceptibility (AST). The system provided an automated platform for preparing, from a single biological sample, inoculates for both ID and AST. The system loads a plate for ID testing as samples are being prepared for AST testing. The system tracks the sample and the inoculates from the samples to link the test results to the sample and the patients from whom the sample was obtained.Type: GrantFiled: July 6, 2011Date of Patent: November 10, 2015Assignee: Becton, Dickinson and CompanyInventors: Robert Edward Armstrong, John Thuin Page, Ben Turng, Glen Richard Davis, Strett Roger Nicolson, Timothy Hansen
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Publication number: 20150125895Abstract: Various embodiments disclosed herein provide for reagents and methods for rapidly isolating viable microbial cells, including S. pneumoniae, from positive blood culture samples. The resulting microbial pellet can be used for both identification and growth-based methods such as antimicrobial susceptibility testing. The buffers described herein may contain a base solution, non-ionic detergents, thiols, and optionally, ammonium chloride. The disclosed methods provide a process for rapidly isolating and concentrating viable microorganism (s) from PBC samples using only one sample preparation tube and centrifugation while removing cellular debris from the mammalian blood cells that may interfere with identification methods.Type: ApplicationFiled: February 28, 2013Publication date: May 7, 2015Applicant: Becton, Dickinson and CompanyInventors: Susan M. Kircher, Vanda White, William B. Brasso, Dyan Luper, James Y. Zhou, Julie L. Rosales, Jeffery H. Bruton, John D. Mantlo, Adrien P. Malick, Donald R. Callihan, Ben Turng, Liping Feng, Curtis M. Gosnell, Patrick Shawn Beaty, John P. Douglass