Abstract: The subject invention pertains to a method for identifying G-quadruplexes (G4s) in a cell using a G4 fluorescent probe, 2-(2-hydroxy-6-methoxy-3-propionylphenyl)quinazolin-4(3H)-one (HMPQ), which exhibits specific binding affinity to G-quadruplexes (G4s), illuminating these non-canonical nucleic acid structures without altering their conformation. G4s are involved in chromatin organisation, gene regulation, genome stability, and appear to contribute to cancer growth and progression. By utilizing HMPQ's unique fluorescence mechanism through excited-state intramolecular proton transfer, the method allows label-free precise detection of G4 structures in the nucleus of a cell.

Abstract: The present disclosure relates to processes for preparing (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]pyrazin-8-yl)-N-(2,2,2-trifluoroethyl) pyrrolidine-1-carboxamide, solid state forms thereof, and corresponding pharmaceutical compositions, methods of treatment (including treatment of rheumatoid arthritis and vasculitis), kits, methods of synthesis, and products-by-process. In various aspects, provided are methods for treating giant cell arteritis (GCA).

Abstract: A gate post column is disclosed, the gate post column has a substantially rectangular cross-section comprising a first substantially flat wall on a first end, two, elongated, flat outside walls immediately adjacent on either side of the first substantially flat wall and opposite one another, the two, elongated flat outside walls each including at a second end opposite the first substantially flat wall, two opposed grooves, the two opposed grooves for receiving a slot cover, such that when the slot cover is in place, the appearance of the two, opposed, elongated, flat outside walls is substantially smooth and flat along its entire width, and a slot, directly opposite the first substantially flat wall at the second end, the slot of sufficient width to accommodate a plurality of slats therewithin the slot.

Abstract: A method for facilitating content lifecycle management via artificial intelligence for AI assisted authoring, AI assisted editing, and phased AI on AI recursive authoring and editing is disclosed. The method includes receiving, via an application programming interface, inquiries in a natural language format, each of the inquiries including freeform data; vectorizing the inquiries to generate numeric sequences; identifying, by using a model, topics for each of the inquiries based on the corresponding numeric sequences, each of the topics including a subject matter value and a sentiment value; aggregating information that corresponds to the topics from various sources, the sources including a preconfigured data lake; determining, by using the model, solutions in the natural language format for each of the inquiries based on the aggregated information, the solutions including recommended actions based on a predetermined setting; and generating, by using the model, a response that includes the solutions.

Abstract: Junction boxes suitable for mounting on exterior surfaces of buildings or other structures are injection molded or otherwise formed to include a housing and lid that are rigidly held together to protect wiring, fluid or other connections within an interior region of the box. The housing and lid may be held together using integrally-formed retention structures. Additional features can provide resistance to water or debris, as well as improved installation and retention of the box relative to the mounting surface. Junction boxes may also include an integrally-formed flashing for mounting on shingle or tile roofs, or similar structures.

Abstract: An energy system includes a generator outputting a first AC signal, a battery outputting a first DC signal to a DC bus, an AC/DC converter receiving and converting the first AC signal into a second DC signal, a DC/AC converter, and a controller. The first and second DC signals are tied to the DC bus. The DC/AC converter receives and converts the first or second DC signal from the DC bus into a second AC signal for an AC outlet interface. The controller controls the AC/DC converter and the DC/AC converter and selects a battery recharge mode where the AC/DC converter outputs the second DC signal to recharge the battery. The controller is operable to select a battery discharge mode where the DC/AC converter receives and converts the first DC signal into the second AC signal to output to the AC outlet interface.

Abstract: A system and method for detecting similar incident records for initiating remediation actions in a computing environment is provided. The method includes: receiving a plurality of incident records, each incident record generated based on extracted values from a plurality of event records; generating an indexed incident record based on a plurality of predetermined categorical attributes; vectorizing a string of categorical attributes to generate a vectorized indexed incident record; storing the vectorized indexed incident record in a vector database; vectorizing a new incident record; querying the vector database based on the vectorized new incident record to detect a similar vector; and generating a similar incident record based on the detected similar vector.

Abstract: Managing a data communication network comprises detecting a bursty data transfer, inferring, using machine learning, a flow burst and pause profile of the bursty data transfer using measurements of the bursty data transfer, and managing the data communication network according to the flow burst and pause profile. Managing the data communication network may include managing the bursty data transfer, managing other data transfers, or both according to the flow burst and pause profile. By using the flow burst and pause profile, the desired performance for the burst data transfer may be more readily achieved and the resources of the data communication network may be more efficiently used.

Abstract: Technology is disclosed herein for a system, devices, and methods for microwave focusing in various implementations. In an implementation, a computing device identifies a location for receiving focused microwave emissions from an array of antennas. The computing device determines an optimal antenna configuration for illuminating the location by the microwave emissions based at least on a configuration of the array and causes the antennas to illuminate the location according to the optimal antenna configuration. In an implementation, the computing device determines the optimal antenna configuration for illuminating the location based on a spatial distribution of material properties of a volume which includes the location. In an implementation, the spatial distribution is based on imaging data of the volume. In various implementations, the configuration of the array includes a spherical or cylindrical distribution of antenna positions.

Abstract: An integrated circuit device includes a digital-to-analog converter with multiple bit slices, each bit slice having a differential pair of driver transistors. A driver circuit includes the differential pairs of driver transistors, multiple series cascode transistors, and current bleed paths to modify drain-to-source currents in the various cascode transistors. Additional embodiments include series peaking circuits, back termination networks, and neutralization capacitors. Other embodiments are disclosed.

Abstract: An illumination system (1) for photodynamic therapy is provided, the illumination system comprising an illumination source (2), which is configured to emit an electromagnetic radiation (3) to illuminate a target surface (4) during operation, and an electronic control unit (5), wherein the illumination source is configured such that the intensity of the electromagnetic radiation emitted by the illumination source can be varied, wherein the electronic control unit is operatively connected to the illumination source and configured to control operation of the illumination source according to an illumination protocol during an illumination session performed with the illumination system, and wherein the illumination protocol comprises instructions to operate the illumination source during the illumination session in a plurality of different modes, the modes comprising: a) a first mode, wherein, in the first mode, the electronic control unit controls operation of the illumination source such that the intensity of th

Abstract: A control system for a military vehicle includes processing circuitry configured to obtain a weight, an incline, a brake air supply pressure, a current gear, and a transaxle range of the military vehicle. The processing circuitry is also configured to determine a minimum brake air supply pressure for the military vehicle based on the weight, the incline, the current gear, and the transaxle range of the military vehicle. The processing circuitry is also configured to compare the brake air supply pressure to the minimum brake air supply pressure, and, in response to the brake air supply pressure being less than the minimum brake air supply pressure, operate a display of the military vehicle to provide an alarm to an operator of the military vehicle to notify the operator that the brake air supply pressure is less than the minimum brake air supply pressure.

Abstract: A first node, a second node, and one or more third nodes for controlling a remote node via RDMA connection are provided. The first node is connected by RDMA connection to the second node and the third nodes, and the second node is connected by RDMA connection to the third nodes. The first node receives a read request for data from the second node, determines at which third node the data is available, and causes the third node to send the data to the second node. The third node is caused to send the data by receiving a RDMA write request or a send for a command from the first node. The third node sends the data by performing a RDMA write operation or a send operation in response to the command written by the first node directly to a send queue at the third node.

Abstract: Endovascular apparatus for determining the condition of a vessel in a body comprises an elongate waveguide element such as a wire and an activation unit comprising a source of ultrasonic energy to activate the waveguide element, hence transmitting ultrasonic energy to an active distal section of the waveguide element. A signal acquisition system acquires feedback signals from the apparatus for interpretation of vessel condition. The signal acquisition system comprises at least one acoustic sensor for acquiring acoustic feedback signals generated by the apparatus when the waveguide element is activated. Data sets may be generated from acoustic and non-acoustic feedback signals and combinations of, or comparisons between, those data sets can characterise the condition of the vessel, including any lesion such as a blockage in the vessel.

Abstract: A recreational vehicle includes a frame, left and right air suspensions, a front jack, a tilt sensor configured to measure lateral and longitudinal tilt data associated with the frame, and a controller. The controller is configured to receive the lateral and longitudinal tilt data to thereby level the frame laterally via operation of the left and right air suspensions and level the frame longitudinally via operation of the left and right air suspensions and the front jack. Methods for performing a leveling operation include utilizing left and right air suspensions of the recreational vehicle in combination with operating a front jack of the recreational vehicle until the recreational vehicle is level along lateral and longitudinal axes.

Abstract: Described is a laser ablation system arranged to dynamically adjust power output to provide increased stability and reduced fluctuations of emitted energy. Additionally described are a test catheter and calibration procedure for calibrating the laser ablation system for to dynamically adjust power output during an ablation procedure.

Abstract: Highly efficient methods are provided for preparing key intermediates in the synthesis of Compound (I), which are broadly applicable and can provide selected components having a variety of substituents groups.

Abstract: In accordance with an embodiment, a data processing method includes: obtaining a first operation command, where the first operation command is used to perform data processing in a relational database; determining an acceleration policy of the first operation command, wherein the acceleration policy is used to accelerate a processing process of the first operation command; and performing an operation of the first operation command based on the acceleration policy.

Abstract: Bone anchor assemblies are disclosed herein that can provide for improved fixation as compared with traditional bone anchor assemblies. An exemplary assembly can include a bracket or wing that extends down from the receiver member and accommodates one or more auxiliary bone anchors that augment the fixation of the assembly's primary bone anchor. Another exemplary assembly can include a plate that is seated between the receiver member and the rod and accommodates one or more auxiliary bone anchors that augment the fixation of the assembly's primary bone anchor. Another exemplary assembly can include a hook that extends out from the receiver member to hook onto an anatomical structure or another implant to augment the fixation of the assembly's primary bone anchor. Surgical methods using the bone anchor assemblies described herein are also disclosed.