Patents by Inventor Ben Zion Katz

Ben Zion Katz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • T-cells comprising two different chimeric antigen receptors and uses thereof
    Patent number: 12139522
    Abstract: The present invention provides T-cells modified to express at least two chimeric antigen receptors, wherein one of the CARs binds specifically to an antigen selected from CD138, HER2 and CD24 and another CAR binds specifically a different antigen selected from CD 138, HER2 and CD24. Further, the invention provides pharmaceutical compositions comprising these CAR T-cells and their use in treatment of cancer, in particular, ovarian cancer, DNA constructs encoding said CARs and methods for preparation of T-cells expressing said CARs.
    Type: Grant
    Filed: December 4, 2018
    Date of Patent: November 12, 2024
    Assignees: THE MEDICAL RESEARCH INFRASTRUCTURE AND HEAL SERVICED FUND OF THE TEL AVIV MEDECAL CENTER, YEDA RESEARCH AND DEVELOPMENT CO. LTD.
    Inventors: Zelig Eshhar, Tova Waks, Anat Globerson Levin, Naamit Deshet-Unger, Moran Rawet Slobodkin, Dan Grisaru, Ben Zion Katz, Ido Laskov
  • T-CELLS COMPRISING TWO DIFFERENT CHIMERIC ANTIGEN RECEPTORS AND USES THEREOF
    Publication number: 20210300986
    Abstract: The present invention provides T-cells modified to express at least two chimeric antigen receptors, wherein one of the CARs binds specifically to an antigen selected from CD138, HER2 and CD24 and another CAR binds specifically a different antigen selected from CD138, HER2 and CD24. Further, the invention provides pharmaceutical compositions comprising these CAR T-cells and their use in treatment of cancer, in particular, ovarian cancer, DNA constructs encoding said CARs and methods for preparation of T-cells expressing said CARs.
    Type: Application
    Filed: December 4, 2018
    Publication date: September 30, 2021
    Inventors: Zelig ESHHAR, Tova WAKS, Anat GLOBERSON LEVIN, Naamit DESHET-UNGER, Moran REWET SLOBODKIN, Dan GRISARU, Ben Zion KATZ, Ido LASKOV
  • USE OF NON-CATALYTIC FORM OF HEPARANASE AND PEPTIDES THEREOF FOR REVERSING THE ANTI-COAGULANT EFFECTS OF HEPARINOIDS
    Publication number: 20110104140
    Abstract: The present invention relates to inhibition of heparinoids anti-coagulation activity by a non-active form of a eukaryotic endoglycosidase or any fragment or peptide thereof comprising at least one heparin-binding domain. More particularly, the invention provides compositions and methods for the inhibition of heparinoids anti-coagulation activity and for the treatment of coagulation related pathologic clinical conditions, using a non-active form of mammalian heparanase or peptides thereof comprising at least one heparin-binding domain.
    Type: Application
    Filed: May 10, 2007
    Publication date: May 5, 2011
    Inventors: Israel Vlodavsky, Neta Ilan, Flonia Levy-Adam, Ben-Zion Katz
  • Methods and kits for diagnosing and monitoring hematopoietic cancers
    Publication number: 20030148321
    Abstract: Methods and kits for distinguishing between heparanase expressing and heparanase non-expressing hematopoietic cells, particularly useful in distinguishing between different types of differentiated and/or undifferentiated lymphomas and leukemias. The methods and kits are designed to detect heparanase expression, or absence thereof, at the gene, protein and/or protein activity levels.
    Type: Application
    Filed: August 26, 2002
    Publication date: August 7, 2003
    Inventors: Iris Pecker, Israel Vlodavsky, Ben Zion Katz, Amiram Eldor, Menachem Bitan, Aaron Polliack, Arnon Nagler, Zofia Eldor