Patents by Inventor Benchun Miao

Benchun Miao has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Small molecule antagonists of phosphatidylinositol-3,4,5-triphosphate (PIP3) and uses thereof
    Patent number: 9040585
    Abstract: Disclosed are new members of a class of non-lipid small molecule inhibitors which interfere with the interaction between phosphoinositol-3,4,5-triphosphate (PIP3) and pleckstrin homology (PH) domains. These molecules target a broad range of PIP3-dependent signaling events in vitro and exert significant anti-tumor activity in vivo, with improved activity and selectivity toward particular PH domains. The small molecule inhibitors of the invention can be used alone or together with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) or other cancer medicament to treat cancer. Small molecule inhibitors of the invention act synergistically in combination with TRAIL and with other Akt inhibitors in treating cancer. Pharmaceutical compositions and methods for treating cancer are provided.
    Type: Grant
    Filed: December 11, 2013
    Date of Patent: May 26, 2015
    Assignees: Tufts University, Council of Scientific and Industrial Research
    Inventors: Alexei Degterev, Chepuri Venkata Ramana, Benchun Miao
  • Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof
    Publication number: 20140187639
    Abstract: Disclosed are new members of a class of non-lipid small molecule inhibitors which interfere with the interaction between phosphoinositol-3,4,5-triphosphate (PIP3) and pleckstrin homology (PH) domains. These molecules target a broad range of PIP3-dependent signaling events in vitro and exert significant anti-tumor activity in vivo, with improved activity and selectivity toward particular PH domains. The small molecule inhibitors of the invention can be used alone or together with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) or other cancer medicament to treat cancer. Small molecule inhibitors of the invention act synergistically in combination with TRAIL and with other Akt inhibitors in treating cancer. Pharmaceutical compositions and methods for treating cancer are provided.
    Type: Application
    Filed: December 11, 2013
    Publication date: July 3, 2014
    Applicants: Council of Scientific and Industrial Research, Tufts University
    Inventors: Alexei Degterev, Chepuri Venkata Ramana, Benchun Miao
  • Small molecule antagonists of phosphatidylinositol-3,4,5-triphosphate (PIP3) and uses thereof
    Patent number: 8628961
    Abstract: Disclosed are new members of a class of non-lipid small molecule inhibitors which interfere with the interaction between phosphoinositol-3,4,5-triphosphate (PIP3) and pleckstrin homology (PH) domains. These molecules target a broad range of PIP3-dependent signaling events in vitro and exert significant anti-tumor activity in vivo, with improved activity and selectivity toward particular PH domains. The small molecule inhibitors of the invention can be used alone or together with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) or other cancer medicament to treat cancer. Small molecule inhibitors of the invention act synergistically in combination with TRAIL and with other Akt inhibitors in treating cancer. Pharmaceutical compositions and methods for treating cancer are provided.
    Type: Grant
    Filed: May 17, 2011
    Date of Patent: January 14, 2014
    Assignees: Tufts University, Council of Scientific and Industrial Research
    Inventors: Alexei Degterev, Chepuri Venkata Ramana, Benchun Miao
  • Small Molecule Antagonists of Phosphatidylinositol-3,4,5-Triphosphate (PIP3) and Uses Thereof
    Publication number: 20120016033
    Abstract: Disclosed are new members of a class of non-lipid small molecule inhibitors which interfere with the interaction between phosphoinositol-3,4,5-triphosphate (PIP3) and pleckstrin homology (PH) domains. These molecules target a broad range of PIP3-dependent signaling events in vitro and exert significant anti-tumor activity in vivo, with improved activity and selectivity toward particular PH domains. The small molecule inhibitors of the invention can be used alone or together with tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) or other cancer medicament to treat cancer. Small molecule inhibitors of the invention act synergistically in combination with TRAIL and with other Akt inhibitors in treating cancer. Pharmaceutical compositions and methods for treating cancer are provided.
    Type: Application
    Filed: May 17, 2011
    Publication date: January 19, 2012
    Applicants: Council of Scientific and Industrial Research, Tufts University
    Inventors: Alexei Degterev, C. V. Ramana, Benchun Miao