Patents by Inventor Benedetto Grimaldi

Benedetto Grimaldi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Synergistic composition as a promoter of autophagy
    Patent number: 11273193
    Abstract: The invention relates to a synergistic composition comprising a dry extract of plant of genus Galeopsis and a compound promoting autophagy selected from biotin and R-N1-spermidine or a salt thereof, wherein R is hydrogen or methyl and mixtures thereof. The synergistic compositions according to the invention may be in the form of a topical formulation or oral formulation and is useful as a promoter of autophagy especially in cells of human scalp hair follicles and in promoting hair growth and/or in the treatment of hair thinning or hair loss.
    Type: Grant
    Filed: August 2, 2018
    Date of Patent: March 15, 2022
    Assignee: GIULIANI S.P.A.
    Inventors: Giammaria Giuliani, Ralf Paus, Benedetto Grimaldi, Barbara Marzani, Sergio Baroni
  • A SYNERGISTIC COMPOSITION AS A PROMOTER OF AUTOPHAGY
    Publication number: 20210177925
    Abstract: The invention relates to a synergistic composition comprising a dry extract of plant of genus Galeopsis and a compound promoting autophagy selected from biotin and R-N1-spermidine or a salt thereof, wherein R is hydrogen or methyl and mixtures thereof. The synergistic compositions according to the invention may be in the form of a topical formulation or oral formulation and is useful as a promoter of autophagy especially in cells of human scalp hair follicles and in promoting hair growth and/or in the treatment of hair thinning or hair loss.
    Type: Application
    Filed: August 2, 2018
    Publication date: June 17, 2021
    Inventors: Giammaria GIULIANI, Ralf PAUS, Benedetto GRIMALDI, Barbara MARZANI, Sergio BARONI
  • Diarylalkylamine REV-ERB antagonists and their use as medicaments
    Patent number: 9949968
    Abstract: The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses as anti-proliferative and proapoptotic agents for cancer therapy.
    Type: Grant
    Filed: November 22, 2016
    Date of Patent: April 24, 2018
    Assignee: Fondazione Istituto Italiano Di Tecnologia
    Inventors: Benedetto Grimaldi, Esther Torrente, Rita Scarpelli, Giovanni Bottegoni, Tiziano Bandiera, Marina Veronesi
  • DIARYLALKYLAMINE REV-ERB ANTAGONISTS AND THEIR USE AS MEDICAMENTS
    Publication number: 20170136009
    Abstract: The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses as anti-proliferative and proapoptotic agents for cancer therapy.
    Type: Application
    Filed: November 22, 2016
    Publication date: May 18, 2017
    Inventors: Benedetto Grimaldi, Esther Torrente, Rita Scarpelli, Giovanni Bottegoni, Tiziano Bandiera, Marina Veronesi
  • Diarylalkylamine REV-ERB antagonists and their use as medicaments
    Patent number: 9611245
    Abstract: The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses as anti-proliferative and pro-apoptotic agents for cancer therapy.
    Type: Grant
    Filed: October 9, 2014
    Date of Patent: April 4, 2017
    Assignee: Fondazione Istituto Italiano Di Tecnologia
    Inventors: Benedetto Grimaldi, Esther Torrente, Rita Scarpelli, Giovanni Bottegoni, Tiziano Bandiera, Marina Veronesi
  • DIARYLALKYLAMINE REV-ERB ANTAGONISTS AND THEIR USE AS MEDICAMENTS
    Publication number: 20160237057
    Abstract: The present invention relates to compounds of Formula (I) or pharmaceutically acceptable salts or solvates thereof: It further discloses a pharmaceutical composition comprising the compounds of Formula (I) and their uses as anti-proliferative and pro-apoptotic agents for cancer therapy.
    Type: Application
    Filed: October 9, 2014
    Publication date: August 18, 2016
    Inventors: Benedetto Grimaldi, Esther Torrente, Rita Scarpelli, Giovanni Bottegoni, Tiziano Bandiera, Marina Veronesi