Patents by Inventor Benedetto Terrana

Benedetto Terrana has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • DNA encoding a synthetic peptide endowed with immunological activity and capable of inducing the production of antibodies with a high specificity towards alpha-fetoprotein
    Patent number: 5206164
    Abstract: A synthetic peptide endowed with immunological activity is disclosed, which is capable of inducing in mammals the formation of anti-peptide antibodies capable of recognizing human alpha-fetoprotein and of reacting with it, and incapable of recognizing albumin or its degradation products, with said peptide being essentially constituted by the aminoacidic sequence of formula (I), corresponding to 38-119 region of human alpha-fetoprotein.Furthermore, the methods and means for preparing said peptide by means of the recombinant DNA techniques are reported.The synthetic peptide (I), like the polyclonal and monoclonal antipeptide antibodies are particularly suitable for the early diagnosis of hepatocellular carcinoma and of teratocarcinoma.
    Type: Grant
    Filed: February 13, 1992
    Date of Patent: April 27, 1993
    Assignee: Sclavo S.p.A.
    Inventors: Mario F. Tecce, Marzia M. Giuliani, Sterfano Ricci, Giulio Rttil, Benedetto Terrana
  • Synthetic peptide endowed with immunological activity, capable of inducing the production of antibodies with a high specificity towards alpha-fetoprotein, and their use in the diagnostic field
    Patent number: 5130415
    Abstract: A synthetic peptide endowed with immunological activity is disclosed, which is capable of inducing in mammals the formation of anti-peptide antibodies capable of recognizing human alpha-fetoprotein and of reacting with it, and incapable of recognizing albumin or its degradation products, with said peptide being essentially constituted by the aminoacidic sequence of formula (I), corresponding to 38-119 region of human alpha-fetoprotein.Furthermore, the methods and means for preparing said peptide by means of the recombinant DNA techniques are reported.The synthetic peptide (I), like the polyclonal and monoclonal antipeptide antibodies are particularly suitable for the early diagnosis of hepatocellular carcinoma and of teratocarcinoma.
    Type: Grant
    Filed: July 24, 1989
    Date of Patent: July 14, 1992
    Assignee: Sclavo S.p.A.
    Inventors: Mario F. Tecce, Marzia M. Giuliani, Stefano Ricci, Giulio Ratti, Benedetto Terrana