Patents by Inventor Benedict J. Marafino, Jr.

Benedict J. Marafino, Jr. has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Treatment for biological damage using a colony stimulating factor and a biological modifier
    Patent number: 5702697
    Abstract: Damage to cells, tissue and other body parts in a mammalian host may be treated by using a colony stimulating factor in conjunction with at least one biological modifier, which may be a free radical scavenger or a metabolic inhibitor. The biological modifier is preferably uric acid, buthionine sulphoximine, vitamin C, aspirin, or nordihydroguaiaretic acid. Such a combination may be used to treat, for example, cancer, infectious diseases, and damage caused by radiation therapy, high oxygen tension, and chemotherapy.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: December 30, 1997
    Assignee: Chiron Corporation
    Inventors: Robert Zimmerman, Benedict J. Marafino, Jr.
  • Treatment for biological damage using tumor necrosis factor and a free-radical scavenger
    Patent number: 5667776
    Abstract: Damage to cells, tissue and other body parts in a mammalian host may be treated by using a tumor necrosis factor in conjunction with at least one biological modifier, which may be a free radical scavenger or a metabolic inhibitor. The biological modifier is preferably uric acid, buthionine sulphoximine, vitamin C, aspirin, or nordihydroguaiaretic acid. Such a combination may be used to treat, for example, cancer, infectious diseases, and damage caused by radiation therapy, high oxygen tension, and chemotherapy.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: September 16, 1997
    Assignee: Chiron Corporation
    Inventors: Robert Zimmerman, Benedict J. Marafino, Jr.
  • Method for treating biological damage using a free-radial scavenger and interleukin-2
    Patent number: 5508031
    Abstract: Damage to cells, tissue and other body parts in a mammalian host may be treated by using a lymphokine or cytotoxin in conjunction with at least one biological modifier, which may be a free radical scavenger or a metabolic inhibitor. The biological modifier is preferably uric acid, buthionine sulphoximine, vitamin C, aspirin, or nordihydroguaiaretic acid. Such a combination may be used to treat, for example, cancer, infectious diseases, and damage caused by radiation therapy, high oxygen tension, and chemotherapy.
    Type: Grant
    Filed: August 12, 1994
    Date of Patent: April 16, 1996
    Assignee: Cetus Oncology Corporation
    Inventors: Robert Zimmerman, Benedict J. Marafino, Jr.
  • Therapeutic combination of free-radical scavenger and tumor necrosis factor
    Patent number: 4985241
    Abstract: Damage to cells, tissue and other body parts in a mammalian host may be treated by using a lymphokine or cytotoxin in conjunction with at least one biological modifier, which may be a free radical scavenger or a metabolic inhibitor. The lymphokine or cytotoxin is preferably tumor necrosis factor and the biological modifier is preferably uric acid, buthionine sulphoximine, vitamin C, aspirin, or nordihydroguaiaretic acid. Such a combination may be used to treat, for example, cancer, infectious diseases, and damage caused by radiation therapy, high oxygen tension, and chemotherapy.
    Type: Grant
    Filed: August 25, 1989
    Date of Patent: January 15, 1991
    Assignee: Cetus Corporation
    Inventors: Robert Zimmerman, Benedict J. Marafino, Jr.