Patents by Inventor Benedicte Foache

Benedicte Foache has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for improving the biocompatibility of solid surfaces
    Patent number: 5350800
    Abstract: A method for attaching a biomolecule having a plurality of carboxyl groups to an aminated solid surface by reacting the biomolecule with a carbodiimide to effect an activation of the carboxyl groups of the biomolecule, reacting the carbodiimide activated biomolecule with the solid surface to covalently bind the biomolecule to the aminated solid surface, and then selectively restoring carboxyl groups to the biomolecule. The selective restoration of carboxyl groups can be carried out by mild hydrolysis and restores the functionality of the biomolecule. The method is "selective" since the bonds between the biomolecule and the aminated solid surface remain intact.
    Type: Grant
    Filed: January 19, 1993
    Date of Patent: September 27, 1994
    Assignee: Medtronic, Inc.
    Inventors: Michel Verhoeven, Patrick Cahalan, Linda Cahalan, Marc Hendriks, Benedicte Foache