Abstract: The invention provides a method for the generation of a layered cellular 3 D microtissue aggregate, comprising the steps of contacting myeloid cells with a protein kinase C agonist, yielding primed myeloid cells; incubating the primed myeloid cells in the presence of LDL in a confined volume, particularly in a hanging drop culture; yielding a 3 D culture of myeloid cells; and incubating the 3 D culture together with fibroblasts in a hanging drop in the presence of LDL, yielding the layered cellular aggregate.

Abstract: The invention provides a method for the generation of a layered cellular 3 D microtissue aggregate, comprising the steps of contacting myeloid cells with a protein kinase C agonist, yielding primed myeloid cells; incubating the primed myeloid cells in the presence of LDL in a confined volume, particularly in a hanging drop culture; yielding a 3 D culture of myeloid cells; and incubating the 3 D culture together with fibroblasts in a hanging drop in the presence of LDL, yielding the layered cellular aggregate.

Abstract: The invention relates to a medical implant, comprising an expandable structure (100) which is designed to be expanded from a crimped state into an expanded state, wherein the structure (100) forms a tubular scaffolding in the expanded state, and wherein the structure (100) comprises a plurality of first struts (101) arranged along a periphery of the structure in said expanded state. According to the invention, the first struts (101) each comprise a recess (O), wherein the medical implant (1) further comprises a sealing member (200) arranged in said recesses (O), wherein said sealing member (200) is formed annularly in said expanded state.

Abstract: A biological heart valve replacement, particularly for pediatric patients, comprises a tubular segment (A) comprising a proximal end (Ep), a distal end (Ed) and a central portion (Pc) arranged between said proximal and distal ends and defining a longitudinal direction of the valve. The valve further comprises at least one inner leaflet (C) attached in hinge-like manner to a connection zone (F) at an inner wall (W) region of said central portion, each one of said inner leaflets being movable between a closing position and an opening position of the valve. In order to provide growth adaptability, the tubular segment comprises at least one tubular growth zone (B; B1,B2) configured as a longitudinal strip made of a growth-adaptive biomaterial, with the remainder of the tubular segment being made of a non-growth-adaptive biomaterial.

Abstract: The method includes a tension element, for example in the form of flat steel, that is placed on the structure or structural part and can be guided around a corner. The flat steel can also wrap as a band around the structure, in which the two ends of the flat steel are either connected to one another or are separately connected to the structure by the end anchors or intersect to produce a clamping connection. The flat steel contracts as a result of a subsequent active and controlled input of heat using a heating element and generates a permanent tensile stress and, correspondingly, a permanent prestress on the structure. The structure, as equipped, has at least one tension element as a shape memory alloy which extends along the outer side of the structure and is connected by one or more end anchors.

Abstract: The method includes a tension element, for example in the form of flat steel, that is placed on the structure or structural part and can be guided around a corner. The flat steel can also wrap as a band around the structure, in which the two ends of the flat steel are either connected to one another or are separately connected to the structure by the end anchors or intersect to produce a clamping connection. The flat steel contracts as a result of a subsequent active and controlled input of heat using a heating element and generates a permanent tensile stress and, correspondingly, a permanent prestress on the structure.

Abstract: The invention relates to a medical implant, comprising an expandable structure (100) which is designed to be expanded from a crimped state into an expanded state, wherein the structure (100) forms a tubular scaffolding in the expanded state, and wherein the structure (100) comprises a plurality of first struts (101) arranged along a periphery of the structure in said expanded state. According to the invention, the first struts (101) each comprise a recess (O), wherein the medical implant (1) further comprises a sealing member (200) arranged in said recesses (O), wherein said sealing member (200) is formed annularly in said expanded state.

Abstract: The invention relates to a method according to which a profile consisting of a shape-memory alloy is placed into concrete, or a concrete to be reinforced is roughened on the outside, then profiles (2) consisting of a shape-memory alloy are fastened to the roughened outside (9) of the structure (6) and a cementitious matrix is applied to the roughened outside (9) to cover the profiles (2). After the cementitious matrix has set, said profiles (2) produce a contraction force and thus a tension as a result of the input of heat. The mortar covering layer (16) thereby acts as a reinforcement layer owing to the interlocking of the mortar covering layer (16) with the roughened outside (9) of the structure (6). The profiles (2) run in an outer mortar as a reinforcement layer (16) of the outside of a structure along the outside of the structure inside the mortar or reinforcement layer (16).

Abstract: A biological heart valve replacement, particularly for pediatric patients, comprises a tubular segment (A) comprising a proximal end (Ep), a distal end (Ed) and a central portion (Pc) arranged between said proximal and distal ends and defining a longitudinal direction of the valve. The valve further comprises at least one inner leaflet (C) attached in hinge-like manner to a connection zone (F) at an inner wall (W) region of said central portion, each one of said inner leaflets being movable between a closing position and an opening position of the valve. In order to provide growth adaptability, the tubular segment comprises at least one tubular growth zone (B; B1,B2) configured as a longitudinal strip made of a growth-adaptive biomaterial, with the remainder of the tubular segment being made of a non-growth-adaptive biomaterial.

Abstract: The invention relates to a method according to which a profile consisting of a shape-memory alloy is placed into concrete, or a concrete to be reinforced is roughened on the outside, then profiles (2) consisting of a shape-memory alloy are fastened to the roughened outside (9) of the structure (6) and a cementitious matrix is applied to the roughened outside (9) to cover the profiles (2). After the cementitious matrix has set, said profiles (2) produce a contraction force and thus a tension as a result of the input of heat. The mortar covering layer (16) thereby acts as a reinforcement layer owing to the interlocking of the mortar covering layer (16) with the roughened outside (9) of the structure (6). The profiles (2) run in an outer mortar as a reinforcement layer (16) of the outside of a structure along the outside of the structure inside the mortar or reinforcement layer (16).