Abstract: The invention provides a device for mixing a pharmaceutical from a solid supply into a parenterally acceptable liquid flowing through a set for parenteral administration of the liquid to a patient, said device comprising a first compartment defining a mixing space through which the liquid flows in a define flow direction and in which the liquid mixes with the pharmaceutical in liquid solution.

Abstract: A particle containing a liquid-soluble active substance for release outside a human or animal body, said particle comprising a core with a coating thereon, said coating comprising a liquid soluble active substance, is characterized in that the core has an appearance differing from the appearance of the coating, and that the appearance of the core is initially concealed by the coating and appears after dissolution of the liquid-soluble active substance, thus indicating that the active substance in said coating has been dissolved. The invention has its foremost application on granules, tablets and similar drug releasing units which make part of a parenteral liquid administration device.

Abstract: A device for release of a solid substance into a flowing liquid during parenteral administration of the liquid to a patient includes a connector (1, with an inlet (6) and an outlet (12) for the liquid, and a valve assembly (4,5). The valve assembly has a valve core (5) which is rotatable between a bypass position and a working position. A releasable container (15), containing the solid substance, may be connected to the valve core (5). In the bypass position, liquid is conducted from the inlet to the outlet, by-passing the container (15). When the valve core (5) is moved to the working position, liquid is diverted into the container (15), for mixing with the solid substance, and then returned to the connector, where it then exits through the outlet (12).

Abstract: A drug release device for inclusion in a parenteral drug delivery system, said device comprising a chamber having an inlet for a liquid administerable to a patient by a parenteral route, a drug dissolution space within said chamber, through which said liquid can be made flow, an outlet for said liquid, and means for receiving and retaining within said drug dissolution space a drug preparation from which a drug is releasable to said liquid during such parenteral delivery, said device characterized in having means for providing the same with one or more durg release cells within which such drug preparation is initially held isolated from the liquid, each of said drug cells having means for emptying its contents of drug preparation into said drug dissolution space after insertion thereof in the drug release device.Such device can be used for sequential emptying of a drug preparation from two or more such drug cells whereby a parenteral liquid dissolves the drug.