Abstract: The present document shows a spring suspension device for an agricultural implement, including a casing, a beam extending through the casing, and four spring elements disposed in a space between the casing and the beam. The casing and the beam are resiliently rotatable relative to each other about a rotational axis extending along a longitudinal direction of the beam. The spring elements differ substantially from each other with respect to shape or material properties, and first and second side faces of the beam, which interact with the respective spring elements, differ substantially from each other with respect to the radius of curvature, viewed in a plane perpendicular to the longitudinal direction.

Abstract: The present document shows a spring suspension device for an agricultural implement, comprising a casing, a beam extending through the casing, and at least two spring elements disposed in a space between the casing and the beam. The casing and the beam are resiliently rotatable relative to each other about a rotational axis extending along a longitudinal direction of the beam. The said at least two spring elements differ substantially from each other with respect to shape and/or material properties, and first and second side faces of the beam, which interact with the respective spring elements, differ substantially from each other with respect to the radius of curvature, viewed in a plane perpendicular to the longitudinal direction.

Abstract: The invention relates to a macromolecule comprising a polymer central core having at least two atoms to which at least two monomers are attached forming a dendrimeric structure comprising at least three polymer bonds, at least two linear polymers (b) being bond to said polymer bonds, wherein said polymers (b) at least have terminal functional groups for cytotoxic agents and at least on extended polymer (a) having a size of at least 1 carbon atoms longer than said polymers (b) and at least a terminal functional group for a targeting agent. The invention also relates to a macromolecule conjugate as well as a macromolecule biotin conjugate comprising said macromolecule, methods to produce said macromolecules as well as kits or system comprising said macromolecules and method of treating a mammal by said macromolecules.

Abstract: A method for the conditioning of an extracorporeal device is described, as well as method for extracorporeal extraction of toxic material from mammalian body fluids in connection with diagnosis or treatment of a mammalian condition or disease, in which methods reagents having the ability to extract toxic material from mammalian body fluids are involved, and an extracorporeal device comprising said reagent.

Abstract: The invention relates to a macromolecule comprising a polymer central core having at least two atoms to which at least two monomers are attached forming a dendrimeric structure comprising at least three polymer bonds, at least two linear polymers (b) being bond to said polymer bonds, wherein said polymers (b) at least have terminal functional groups for cytotoxic agents and at least on extended polymer (a) having a size of at least 1 carbon atoms longer than said polymers (b) and at least a terminal functional group for a targeting agent. The invention also relates to a macromolecule conjugate as well as a macromolecule biotin conjugate comprising said macromolecule, methods to produce said macromolecules as well as kits or system comprising said macromolecules and method of treating a mammal by said macromolecules.

Abstract: The invention relates to an adsorption device for removal and/or reduction of undesirable components from blood, such as whole blood, comprising, porous cross-linked polysaccharide particles or beads, wherein the particles or beads have an average size from about 210±50 ?m, at least 30% of the particles have a size from about 180 to about 240 ?m, at least 70% of the particles have a size from about 150 to about 300 ?m and said particles have at least one immobilised ligand, wherein said immobilised ligand have a size of about 150 kD or less. The invention also relates to kits comprising said adsorption device as well as the use of said adsorption device in different applications such as cleaning of blood.

Abstract: A reagent for conjugation to a biomolecule, wherein the reagent is a single molecule with at least three functional parts and has schematic structure (I): a) wherein a trifunctional cross-linking moiety is coupled to b) an affinity ligand via a linker 1, said affinity ligand being capable of binding with another molecule having affinity for said ligand, to c) an effector agent, optionally via a linker 2, said effector agent exerting its effect on cells, tissues and/or humorous molecules in vivo or ex vivo, and to d) a biomolecule reactive moiety, optionally via a linker 3, said moiety being capable of forming a bond between the reagent and the biomolecule.

Abstract: A medical agent comprising a reagent conjugated to an anti-lymphoma antibody is disclosed, as well as a kit containing said medical agent, use of said medical agent, and a method for treatment of lymphoma. The reagent may comprise an effector, e.g. an antitumor agent or a diagnostic marker, and an affinity ligand enabling extracorporeal clearance of the agent. The three components are bound by a trifunctional linker.

Abstract: At least one alkyl paraben is used in an aqueous antimicrobial preservation composition for eliminating or reducing the microbial content of a microbially contaminated separation matrix, which is to be used in a housing of a separation device, the separation matrix being microbially contaminated. Also, in a method of producing a separation matrix with eliminated or reduced microbial content, the method comprises the steps of providing said separation matrix, microbially contaminated, in a housing or container; adding an aqueous antimicrobial preservation composition, which comprises at least one alkyl paraben, to said separation matrix in said housing or container; allowing said aqueous antimicrobial preservation composition to exert its effect in said housing or container until the number of colony forming units (CFU) per g preservative composition is sufficiently reduced; and rinsing said aqueous antimicrobial preservation composition from said housing or container.

Abstract: A reagent for conjugation to a biomolecule for diagnosis and treatment of human and animal conditions and diseases is described, wherein the reagent is a single molecule with at least three functional parts and has schematic structure (1), a) wherein a trifunctional cross-linking moiety is coupled to b) an affinity ligand via a linker 1, said affinity ligand being capable of binding with another molecule having affinity for said ligand to c) an effector agent, optionally via a linker 2, said effector agent exerting its effects on cells, tissues and/or humorous molecules in vivo or ex vivo, and to d) a biomolecule reactive moiety, optionally via a linker 3, said moiety being capable of forming a bond between the reagent and the biomolecule.

Abstract: A method for the conditioning of an extracorporeal device is described, as well as method for extracorporeal extraction of toxic material from mammalian body fluids in connection with diagnosis or treatment of a mammalian condition or disease, in which methods reagents having the ability to extract toxic material from mammalian body fluids are involved, and an extracorporeal device comprising said reagent.

Abstract: A method and a system is described for reducing non-target levels of specific molecules intended for diagnostic and/or therapeutic applications to vertebrate hosts, wherein said molecules are administered to a vertebrate host and kept therein for a certain time in order to be concentrate to the target by being attached thereto. The molecules which are not attached to the target are removed from the blood circulation system or at least reduced to a lower concentration by passing the blood through an extra-corporeal device.