Patents by Inventor Benjamin A. De Burgh

Benjamin A. De Burgh has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Human anti-RH(D) monoclonal antibodies, cell lines and methods of use of antibodies in immunoassays
    Patent number: 5496548
    Abstract: The present invention provides human monoclonal antibodies having the following essential characteristics: (a) binding to Rh(D) antigen, but not C, c, E or e antigens of the Rh blood group system; (b) being IgG3 proteins; (c) having kappa light chains; (d) being of the allotype G3m(21); (e) binding to D.sup.u cells by an indirect antiglobulin test; (f) binding to D.sup.IV, D.sup.V and D.sup.VII variant antigens; and (g) not binding to D.sup.VI or D.sup.B variant antigens, which may be employed for Rh-typing of red blood cells and passive immunization to prevent hemolytic disease of the newborn. Such a monoclonal antibody is exemplified by the monoclonal antibody of cell line ECACC 87091606 deposited at the European Collection of Animal Cell Cultures, Public Health Laboratory Service Center for Applied Microbiology and Research, Porton Down, Salisbury, Wiltshire, SP4, OJG, England of Sep. 16, 1987.
    Type: Grant
    Filed: April 13, 1993
    Date of Patent: March 5, 1996
    Assignee: National Blood Authority
    Inventors: Benjamin A. De Burgh, Alan Doyle, Belinda M. Kumpel