Abstract: A non-occluding intravascular pump comprises a shroud providing an inlet for incoming blood flow and an outlet for outgoing blood flow, wherein the shroud is a cylindrical housing; an impeller positioned within shroud, wherein a central axis of the shroud and impeller are shared; a motor coupled to the impeller, wherein the motor rotates the impeller to causes blood to be drawn through the inlet and output to the outlet, and the motor is centrally disposed and shares the central axis with the shroud and the impeller; and a plurality of pillars coupling the motor to the shroud, wherein the pillars secure the shroud in close proximity to the impeller. Various design features of the pump may be optimized to reduce hemolysis, such as, but not limited to, inlet length, impeller design, pillar angle, and outlet design.

Abstract: A non-occluding intravascular pump comprises a shroud providing an inlet for incoming blood flow and an outlet for outgoing blood flow, wherein the shroud is a cylindrical housing; an impeller positioned within shroud, wherein a central axis of the shroud and impeller are shared; a motor coupled to the impeller, wherein the motor rotates the impeller to causes blood to be drawn through the inlet and output to the outlet, and the motor is centrally disposed and shares the central axis with the shroud and the impeller; and a plurality of pillars coupling the motor to the shroud, wherein the pillars secure the shroud in close proximity to the impeller. Various design features of the pump may be optimized to reduce hemolysis, such as, but not limited to, inlet length, impeller design, pillar angle, and outlet design.

Abstract: A non-occluding intravascular pump comprises a shroud providing an inlet for incoming blood flow and an outlet for outgoing blood flow, wherein the shroud is a cylindrical housing; an impeller positioned within shroud, wherein a central axis of the shroud and impeller are shared; a motor coupled to the impeller, wherein the motor rotates the impeller to causes blood to be drawn through the inlet and output to the outlet, and the motor is centrally disposed and shares the central axis with the shroud and the impeller; and a plurality of pillars coupling the motor to the shroud, wherein the pillars secure the shroud in close proximity to the impeller. Various design features of the pump may be optimized to reduce hemolysis, such as, but not limited to, inlet length, impeller design, pillar angle, and outlet design.

Abstract: A non-occluding intravascular pump comprises a shroud providing an inlet for incoming blood flow and an outlet for outgoing blood flow, wherein the shroud is a cylindrical housing; an impeller positioned within shroud, wherein a central axis of the shroud and impeller are shared; a motor coupled to the impeller, wherein the motor rotates the impeller to causes blood to be drawn through the inlet and output to the outlet, and the motor is centrally disposed and shares the central axis with the shroud and the impeller; and a plurality of pillars coupling the motor to the shroud, wherein the pillars secure the shroud in close proximity to the impeller. Various design features of the pump may be optimized to reduce hemolysis, such as, but not limited to, inlet length, impeller design, pillar angle, and outlet design.

Abstract: Fluid pressure or flow in a human body may be adjusted with circulation or perfusion systems and methods. The system may include a first pump implantable in a chamber or vessel of the human body, and a plurality of struts connected to a housing of the first pump, wherein the struts secure the first pump in a desired location of the chamber or vessel. The system may also include one or more flow modification elements disposed on the first pump, where the flow modification elements direct flow to a desired organ or a desired vessel to adjust pressure or flow as desired.

Abstract: Systems and methods for providing a magnetic fluid (MF) seal suitable for a fluid environment may provide a shaft and a magnet that is cylindrical or ring-shaped. A magnetic fluid may be present between the magnet and shaft. Additionally, pole pieces may also be provided, which are also cylindrical or ring-shaped. These pole pieces are positioned on the shaft so the magnet is sandwiched between the pole pieces. The magnet, pole pieces, and shaft, if magnetic, may attract and retain the magnetic fluid in an annular gap or region between the shaft and the magnet and/or the pole pieces. The magnetic fluid in the annular gap serves as a seal or barrier that prevents fluid from passing through when pressure is below a predetermined level.

Abstract: Systems and methods for providing a magnetic fluid (MF) seal suitable for a fluid environment may provide a shaft and a magnet that is cylindrical or ring-shaped. A magnetic fluid may be present between the magnet and shaft. Additionally, pole pieces may also be provided, which are also cylindrical or ring-shaped. These pole pieces are positioned on the shaft so the magnet is sandwiched between the pole pieces. The magnet, pole pieces, and shaft, if magnetic, may attract and retain the magnetic fluid in an annular gap or region between the shaft and the magnet and/or the pole pieces. The magnetic fluid in the annular gap serves as a seal or barrier that prevents fluid from passing through when pressure is below a predetermined level.

Abstract: Fluid pressure or flow in a human body may be adjusted with circulation or perfusion systems and methods. The system may include a first pump implantable in a chamber or vessel of the human body, and a plurality of struts connected to a housing of said first pump, wherein the struts secure the first pump in a desired location of the chamber or vessel. The system may also include one or more flow modification elements disposed on the first pump, where the flow modification elements direct flow to a desired organ or a desired vessel to adjust pressure or flow as desired.

Abstract: A non-occluding intravascular pump comprises a shroud providing an inlet for incoming blood flow and an outlet for outgoing blood flow, wherein the shroud is a cylindrical housing; an impeller positioned within shroud, wherein a central axis of the shroud and impeller are shared; a motor coupled to the impeller, wherein the motor rotates the impeller to causes blood to be drawn through the inlet and output to the outlet, and the motor is centrally disposed and shares the central axis with the shroud and the impeller; and a plurality of pillars coupling the motor to the shroud, wherein the pillars secure the shroud in close proximity to the impeller. Various design features of the pump may be optimized to reduce hemolysis, such as, but not limited to, inlet length, impeller design, pillar angle, and outlet design.

Abstract: Fluid pressure or flow in a human body may be adjusted with circulation or perfusion systems and methods. The system may include a first pump implantable in a chamber or vessel of the human body, and a plurality of struts connected to a housing of said first pump, wherein the struts secure the first pump in a desired location of the chamber or vessel. The system may also include one or more flow modification elements disposed on the first pump, where the flow modification elements direct flow to a desired organ or a desired vessel to adjust pressure or flow as desired.

Abstract: Fluid pressure or flow in a human body may be adjusted with circulation or perfusion systems and methods. The system may include a first pump implantable in a chamber or vessel of the human body, and a plurality of struts connected to a housing of said first pump, wherein said struts secure the first pump in a desired location of said chamber or vessel. The system may also include one or more flow modification elements disposed on said first pump, where said flow modification elements direct flow to a desired organ or a desired vessel to adjust pressure or flow as desired.

Abstract: Methods and compositions are provided for enhancing the bioadhesive properties of polymers used in drug delivery systems. The bioadhesive properties of a base polymer are enhanced by incorporating a short chain polymer with one or more free carboxylic groups into the base polymer to enhance the ability of the base polymer to adhere to a tissue surface such as a mucosal membrane. The short chain polymers can be incorporated within a wide range of base polymers including proteins, polysaccharides and synthetic biocompatible polymers. In one embodiment, short chain polymers can be incorporated within base polymers used to form or coat drug delivery systems, such as microspheres, which contain a drug or diagnostic agent. The short chain polymers can either be solubilized and blended with the base polymer before manufacture or else used as a coating with base polymers over existing systems.

Abstract: Methods and compositions are provided for enhancing the bioadhesive properties of polymers used in drug delivery systems. The bioadhesive properties of a polymer are enhanced by incorporating an anhydride oligomer into the polymer to enhance the ability of the polymer to adhere to a tissue surface such as a mucosal membrane. Anhydride oligomers which enhance the bioadhesive properties of a polymer include oligomers synthesized from dicarboxylic acid monomers, preferably those found in Krebs glycolysis cycle, especially fumaric acid. The oligomers can be incorporated within a wide range of polymers including proteins, polysaccharides and synthetic biocompatible polymers. In one embodiment, anhydride oligomers can be incorporated within polymers used to form or coat drug delivery systems, such as microspheres, which contain a drug or diagnostic agent. The oligomers can either be solubilized and blended with the polymer before manufacture or else used as a coating with polymers over existing systems.

Abstract: Methods and compositions are provided for enhancing the bioadhesive properties of polymers used in drug delivery systems. The bioadhesive properties of a polymer are enhanced by incorporating an anhydride oligomer into the polymer to enhance the ability of the polymer to adhere to a tissue surface such as a mucosal membrane. Anhydride oligomers which enhance the bioadhesive properties of a polymer include oligomers synthesized from dicarboxylic acid monomers, preferably those found in Krebs glycolysis cycle, especially fumaric acid. The oligomers can be incorporated within a wide range of polymers including proteins, polysaccharides and synthetic biocompatible polymers. In one embodiment, anhydride oligomers can be incorporated within polymers used to form or coat drug delivery systems, such as microspheres, which contain a drug or diagnostic agent. The oligomers can either be solubilized and blended with the polymer before manufacture or else used as a coating with polymers over existing systems.

Abstract: Methods and compositions are provided for enhancing the bioadhesive properties of polymers used in drug delivery systems. The bioadhesive properties of a polymer are enhanced by incorporating an anhydride oligomer into the polymer to enhance the ability of the polymer to adhere to a tissue surface such as a mucosal membrane. Anhydride oligomers which enhance the bioadhesive properties of a polymer include oligomers synthesized from dicarboxylic acid monomers, preferably those found in Krebs glycolysis cycle, especially fumaric acid. The oligomers can be incorporated within a wide range of polymers including proteins, polysaccharides and synthetic biocompatible polymers. In one embodiment, anhydride oligomers can be incorporated within polymers used to form or coat drug delivery systems, such as microspheres, which contain a drug or diagnostic agent. The oligomers can either be solubilized and blended with the polymer before manufacture or else used as a coating with polymers over existing systems.