Patents by Inventor Benjamin A.L. Buller

Benjamin A.L. Buller has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Methods, systems, and compositions relating to MiRNA-146a
    Patent number: 10308959
    Abstract: Some embodiments comprise methods, systems, and compositions to promote, improve and/or increase neuronal differentiation, oligodendrocyte differentiation, or neurological outcome or function in a patient in need thereof. Some embodiments also comprise the administration a composition comprising a pharmaceutically effective amount of one or more of a group comprising microRNA-146a, exosomes comprising microRNA-146a, a promoter of microRNA-146a expression, a microRNA-146a thymosin beta 4, and a phosphodiesterase 5 inhibitor to treat neurological conditions, diseases, or injuries in mammals, including in human beings.
    Type: Grant
    Filed: May 19, 2017
    Date of Patent: June 4, 2019
    Assignee: Henry Ford Health System
    Inventors: Xianshuang Liu, Zhenggang Zhang, Michael Chopp, Lei Wang, Benjamin A. L. Buller
  • Methods, systems, and compositions for cell-derived/vesicle-based microRNA delivery
    Patent number: 10227593
    Abstract: Some embodiments comprise methods, systems, and compositions to produce and/or administer modified exosomes or other vesicles containing one or more selected microRNAs, including but not limited to, miR-146b. Some embodiments also comprise the therapeutic administration and use of such modified exosomes and/or producer cells to treat mammalian brain or neurologic injuries and diseases, including in human beings.
    Type: Grant
    Filed: December 23, 2016
    Date of Patent: March 12, 2019
    Assignee: Henry Ford Health System
    Inventors: Mark E. Katakowski, Benjamin A. L. Buller, Michael Chopp
  • METHODS, SYSTEMS, AND COMPOSITIONS RELATING TO MiRNA-146a
    Publication number: 20170321225
    Abstract: Some embodiments comprise methods, systems, and compositions to promote, improve and/or increase neuronal differentiation, oligodendrocyte differentiation, or neurological outcome or function in a patient in need thereof. Some embodiments also comprise the administration a composition comprising a pharmaceutically effective amount of one or more of a group comprising microRNA-146a, exosomes comprising microRNA-146a, a promoter of microRNA-146a expression, a microRNA-146a thymosin beta 4, and a phosphodiesterase 5 inhibitor to treat neurological conditions, diseases, or injuries in mammals, including in human beings.
    Type: Application
    Filed: May 19, 2017
    Publication date: November 9, 2017
    Inventors: Xianshuang Liu, Zhenggang Zhang, Michael Chopp, Lei Wang, Benjamin A.L. Buller
  • METHODS, SYSTEMS, AND COMPOSITIONS FOR CELL-DERIVED/VESICLE-BASED MICRORNA DELIVERY
    Publication number: 20170247708
    Abstract: Some embodiments comprise methods, systems, and compositions to produce and/or administer modified exosomes or other vesicles containing one or more selected microRNAs, including but not limited to, miR-146b. Some embodiments also comprise the therapeutic administration and use of such modified exosomes and/or producer cells to treat mammalian brain or neurologic injuries and diseases, including in human beings.
    Type: Application
    Filed: December 23, 2016
    Publication date: August 31, 2017
    Applicant: Henry Ford Health System
    Inventors: Mark E. Katakowski, Benjamin A.L. Buller, Michael Chopp
  • Methods, systems, and compositions for cell-derived/vesicle-based microrna delivery
    Patent number: 9555060
    Abstract: Some embodiments comprise methods, systems, and compositions to produce and/or administer modified exosomes or other vesicles containing one or more selected microRNAs, including but not limited to, miR-146b. Some embodiments also comprise the therapeutic administration and use of such modified exosomes and/or producer cells to treat mammalian injuries and diseases, including in human beings.
    Type: Grant
    Filed: December 13, 2012
    Date of Patent: January 31, 2017
    Assignee: Henry Ford Health System
    Inventors: Mark E. Katakowski, Benjamin A. L. Buller, Michael Chopp
  • METHODS, SYSTEMS, AND COMPOSITIONS FOR CELL-DERIVED/VESICLE-BASED MICRORNA DELIVERY
    Publication number: 20150157666
    Abstract: Some embodiments comprise methods, systems, and compositions to produce and/or administer modified exosomes or other vesicles containing one or more selected microRNAs, including but not limited to, miR-146b. Some embodiments also comprise the therapeutic administration and use of such modified exosomes and/or producer cells to treat mammalian injuries and diseases, including in human beings.
    Type: Application
    Filed: December 13, 2012
    Publication date: June 11, 2015
    Applicant: Henry Ford Health System
    Inventors: Mark E. Katakowski, Benjamin A.L. Buller, Michael Chopp