Abstract: Methods, apparatuses, and systems for device tracking and geofencing reporting are disclosed herein. An apparatus (e.g., smart radio) carried by a worker includes location tracking and/or machine-to-machine communication components and a speaker. A machine in a work facility that does not otherwise include local, short-range reporting apparatus (e.g., a speaker) is equipped with a sensor suite configured to detect issues therewith. As a worker carrying a smart radio walks by a machine with a detected issue requiring repair or maintenance, the smart radio issues an auditory notification describing the issue, which enables the worker to stop and address the issue while they are in the local area of the machine. The smart radio thus operates as a speaker for the machine.

Abstract: Some methods may involve receiving a first content stream that includes first audio signals, rendering the first audio signals to produce first audio playback signals, generating first calibration signals, generating first modified audio playback signals by inserting the first calibration signals into the first audio playback signals, and causing a loudspeaker system to play back the first modified audio playback signals, to generate first audio device playback sound. The method(s) may involve receiving microphone signals corresponding to at least the first audio device playback sound and to second through Nth audio device playback sound corresponding to second through Nth modified audio playback signals (including second through Nth calibration signals) played back by second through Nth audio devices, extracting second through Nth calibration signals from the microphone signals and estimating at least one acoustic scene metric based, at least partly, on the second through Nth calibration signals.

Abstract: An apparatus for emitting electromagnetic radiation includes a gain element, an optical arrangement defining a resonator and arranged to re-direct radiation emitted by the gain element along a beam path back onto the gain element, the optical arrangement including an output coupler configured to couple a portion of the radiation in the resonator out of the resonator, and a pump arrangement configured to pump the gain element. The optical arrangement further includes a passive device placed in the resonator in the beam path, the passive device having at least two surface portions at an angle to each other. The passive device is arranged to direct first radiation portions and second radiation portions of the radiation, which first and second radiation portions are incident on different ones of the surface portions, to be spatially separated. The apparatus is suitable as a source of dual-comb pulsed laser radiation.

Abstract: Provided herein are methods of producing a photoreceptor precursor (PRP) cell population derived from stem cells. Further provided herein are methods of using the PRP cell populations, such as for therapeutics.

Abstract: A server system transmits from an application executing on a virtual client device, through a remote physical client device, a request for a manifest. The server system receives, a manifest received by, and forwarded from, the remote physical client device. The server system determines whether the server system is authorized to modify the received manifest. In response to determining that the server system is authorized to modify the received manifest, the server system requests additional content to modify the received manifest. The server system modifies listed content in the received manifest to generate an updated manifest. The server system sends the updated manifest to the application at the server system. The application processes the updated manifest. The server system sends, to the remote physical client device, an instruction to request the additional content.

Abstract: A hair care accessory is provided for use in drying and/or styling hair. The hair care accessory can include an elongate frame having a longitudinal axis and an inner lumen extending there through along the longitudinal axis. The hair care accessory can also include a plurality of plates disposed on the elongate frame. The plurality of plates can include a first row of plates that can be spaced circumferentially around a first longitudinal portion of the elongate frame, and at least one second row of plates that can be spaced circumferentially around a second longitudinal portion of the elongate frame. Each plate in the first row of plates can define a first longitudinally extending outlet and each plate in the second row of plates can define a second longitudinally extending outlet. The second longitudinally extending outlet being circumferentially offset from the first longitudinally extending outlet.

Abstract: Systems, devices, and methods are disclosed for computer-assisted goal setting and tracking with respect to neuromodulation device treatment. A digital health system includes a user-interface device to receive a user input about a personalized objective of neuromodulation treatment or an intended manner of using the neuromodulation device by the patient. The user input can be in forms of text, voice, or other unstructured or unclassified data formats. A controller circuit can process the user input using analytical methods including natural language processing to generate a personalized treatment and device usage goal, and track the progress toward the personalized treatment and device usage goal using patient state information. The tracked progress may be presented to the patient, or be used to initiate or adjust a neuromodulation therapy.

Abstract: Systems, devices, and methods are disclosed for computer-assisted goal setting and tracking with respect to neuromodulation device treatment. A digital health system includes a user-interface device to receive a user input about a personalized objective of neuromodulation treatment or an intended manner of using the neuromodulation device by the patient. The user input can be in forms of text, voice, or other unstructured or unclassified data formats. A controller circuit can process the user input using analytical methods including natural language processing to generate a personalized treatment and device usage goal, and track the progress toward the personalized treatment and device usage goal using patient state information. The tracked progress may be presented to the patient, or be used to initiate or adjust a neuromodulation therapy.

Abstract: A medical system may include a patient system configured for use to determine health-related information for a patient, and deliver a neuromodulation therapy. The patient system may include a patient device having a user interface, storage for storing patient assistance data for each of a plurality of issues that may adversely affect patient satisfaction with the patient system, and a satisfaction monitor configured to determine, from the health-related information, that at least one of the plurality of issues may be adversely affecting the patient satisfaction, and send the patient assistance data, that corresponds to the at least one of the plurality of issues, to the user interface.

Abstract: This document discusses systems, devices, and methods for monitoring and managing patients with chronic pain. A patient monitoring system comprises a sensor circuit to sense a physiological or functional signal indicative of or correlated to patient mobility, an electrostimulator to generate and deliver neuromodulation therapy to the patient, and a controller circuit to generate a mobility metric using the sensed physiological or functional signal. The mobility metric represents respective times spent in different activity intensity levels associated with one or more types of activities during a specific time period. The controller circuit can trend the mobility metric over time and determine a progress toward a personalized mobility goal of the patient, and control the electrostimulator to initiate or adjust the neuromodulation therapy in accordance with the trended mobility metric or the determined progress toward the mobility goal.

Abstract: A steering system for a wheelchair includes a steering device configured to be engaged by a user, a front wheel operably connected to the steering device, and a frame assembly configured to carry the steering device and the front wheel. The frame assembly is configured to removably engage a mounting member of the wheelchair. A mounting assembly can be coupled to the frame assembly. The mounting assembly is configured to selectively couple to the mounting member of the wheelchair and selectively electrically connect to a motorized drive assembly coupled to the wheelchair.

Abstract: A wheelchair including a steering assembly configured to selectively attach to the wheelchair, the steering assembly including a steering member, a front wheel operably connected to the steering member, a frame assembly configured to carry the steering member and the front wheel, and a mounting assembly coupled to the frame assembly, and a drive assembly coupled to the wheelchair. The drive assembly is configured to operate in a first configuration in response to the steering assembly being detached from the wheelchair, and the drive assembly is configured to operate in a second configuration in response to the steering assembly being attached to the wheelchair.

Abstract: An alignment system for a wheelchair based steering column includes a fork assembly configured to carry a front wheel, a bearing coupled to the fork assembly, a tube member that receives the bearing and a portion of the fork assembly, a cam defining sloped cam surface leading to a recess, the cam positioned in the tube member, a biasing member configured to apply a restoring force onto the cam, the biasing member positioned in the tube member, and a steering device coupled to the fork assembly. In response to applying a rotational force to the steering device, the fork assembly rotates, responsively rotating the front wheel and sliding the bearing along the cam surface away from the recess, the cam responsively linearly translates relative to the fork assembly overcoming the restoring force.

Abstract: Systems and techniques are disclosed to evaluate a neurostimulation treatment provided from a neurostimulation device, based on freeform text analysis. In an example, a system or device to evaluate a neurostimulation treatment provided from a neurostimulation device is configured to perform operations that: obtain text content, originating from text or voice input of a human patient, which relates to a state of a human patient; identify a state of the human patient from natural language processing of the text content; obtain device data from the neurostimulation device; identify a state of the neurostimulation treatment of the human patient from the device data; associate the identified state of the human patient to the identified state of the neurostimulation treatment; and initiate an action for the neurostimulation treatment, based on the identified state of the human patient that is associated with the identified state of the neurostimulation treatment.

Abstract: This document discusses a computer-implemented method of machine recognition of a physiological condition of a subject. The computer-implemented method comprises obtaining a video stream of the subject using a video data source; identifying, using processing circuitry, one or more areas within image frames of the video stream that contain a physiological feature of the subject; analyzing video data of the identified one or more areas in the image frames using the processing circuitry to detect change of the physiological feature between a first frame of video data and a later frame of video data; determining one or more change parameters of the physiological feature from the video data; and generating an indication of a symptom of Parkinson's Disease according to a detection criterion applied to the one or more change parameters.

Abstract: A system may include at least one data collection platform and an event detector configured to detect an event. The at least one data collection platform may be configured for use to collect healthcare-related data at a defined data resolution for transfer to a data receiving system that may include one or more processors, at least one data input for receiving healthcare-related data, and memory for storing instructions for implementation by the one or more processors to collect healthcare-related data via the at least one data input. The at least one data collection platform may be configured to change the data resolution for collecting healthcare-related data in response to the detected event.

Abstract: A control module for an electrical stimulation system includes a sealed electronics housing; an electronic subassembly disposed within the electronics housing; one or more connector assemblies coupled to the electronic subassembly; and a rechargeable battery disposed external to the electronics housing. The one or more connector assemblies are configured to receive a lead. The rechargeable battery includes a positive electrode, a negative electrode, and a single battery case attached directly to the sealed electronics housing and forming a sealed cavity that encapsulates both the positive electrode and the negative electrode. The battery case is electrically isolated from each of the positive electrode and the battery electrode.

Abstract: This document discusses systems, devices, and methods for computer-assisted pain or paresthesia assessment and pain management in a subject. A system includes a programming aid device including a user interface, a transceiver circuit to receive information about pain management for the patient from one or more of a software-based virtual agent (SVA) or a human assistant other than the patient, and a controller circuit to initiate and manage information exchange session between the patient and one or more of the SVA or the human assistant, via the user interface, regarding pain or paresthesia sensation and pain management. Based on the information exchange, the controller determines a stimulation setting, and generate a therapy control signal to the neuromodulation device to initiate delivery of neuromodulation energy according to the determined stimulation setting.

Abstract: This invention relates to high concentration solid oral dosage forms of a ketamine metabolite selected from 2R,6R-hydroxynorketamine, 2S,6S-hydroxynorketamine, R-5,6-dehydronorketamine and S-5,6-dehydronorketamine.

Abstract: Provided herein are methods and markers for diagnosing cardiovascular disease and/or neurodegenearative diseases in a subject. The methods include obtaining a biological sample from a subject in need of diagnosis and detecting the amount of a citrullinated protein or a citrullinated peptide in the biological sample obtained from said subject.