Abstract: A process is provided for making a WEE1 inhibitor of the formula (1A) useful in the treatment of conditions characterized by excessive cellular proliferation, such as cancer. In some embodiments, processes are provided for making intermediate compounds of the formulae (3), (5) and (6) as defined herein.

Abstract: Substituted cyclohexyl chemical entities of Formula (I): wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders.

Abstract: A wound therapy system includes a therapy unit, a wound dressing and an optional controller. The therapy unit is configured to deliver instillation fluid to a wound site. The wound dressing is formed from a plurality of discrete, individual blocks that are selectively separable from one another along a plurality of separation-lines, allowing the wound dressing to be customized to the shape and size of the wound site. By calculating the remaining blocks that define the wound dressing following customization, the volume of the wound dressing may be determined. The controller may be configured to deliver fluid to the wound site based on this calculated volume. The controller may also optionally be used to gauge the healing of the wound site over time by monitoring the changes in volume of customized wound dressings as wound dressings are replaced during the course of treatment of the wound site.

Abstract: One implementation of the present disclosure is a method for dynamically controlling an alarm of a negative pressure wound therapy (NPWT) device, according to some embodiments. In some embodiments, the method includes initiating NPWT, comparing an initial pump duty to a threshold value to determine a dressing application quality, monitoring a leakage rate of the NPWT, setting a leak threshold value based on the dressing application quality, determining leakage event occurrences in response to the leakage rate exceeding the leak threshold value at multiple times, adjusting the leak threshold value based on at least one of a number of the leakage events over the time period, a time duration between sequentially occurring leakage events of the leakage events, and the dressing application quality, and causing a user interface device to display a leak alert in response to the leakage rate exceeding the adjusted leak threshold value.

Abstract: One implementation of the present disclosure is a method for dynamically controlling an alarm of a negative pressure wound therapy (NPWT) device, according to some embodiments. In some embodiments, the method includes initiating NPWT, comparing an initial pump duty to a threshold value to determine a dressing application quality, monitoring a leakage rate of the NPWT, setting a leak threshold value based on the dressing application quality, determining leakage event occurrences in response to the leakage rate exceeding the leak threshold value at multiple times, adjusting the leak threshold value based on at least one of a number of the leakage events over the time period, a time duration between sequentially occurring leakage events of the leakage events, and the dressing application quality, and causing a user interface device to display a leak alert in response to the leakage rate exceeding the adjusted leak threshold value.

Abstract: A system for providing instillation fluid to a deep abdominal wound includes an instillation module and a connection structure. The instillation module defines a first surface and a second, abdominal contents-facing surface. The instillation module includes a distribution hub configured to receive instillation fluid from an instillation fluid source. The connection structure includes a first surface, a second, abdominal contents-facing surface; and a flow path extending between the first surface and the second surface. The flow path includes an inlet configured to receive an instillation fluid conduit engaged with the instillation fluid source and an outlet in fluid communication with the instillation module. The flow path defines an axis extending between the inlet and the outlet. The flow path is configured to compress in a direction defined by the axis.

Abstract: A negative pressure wound therapy device, kit, and method are provided for improved treatment of wounds on complex three-dimensional anatomies. The device includes a conformable manifold made of a porous and permeable material with a pattern of cuts designed to transform the manifold from a relaxed, planar state to a pliable three-dimensional state when extended along the lateral axis. The kit further may include a wound interface layer, an adhesive, breathable drape, and a pneumatic connection to a negative pressure wound therapy device. Finally, a method for treating wounds using reduced pressure and the presently disclosed kit is provided.

Abstract: A negative pressure wound therapy system includes at least one sensor coupled to a wound dressing for a wound of a patient, and a processing circuit. The at least one sensor is configured to output a measurement of the pressure in the wound dressing. The processing circuit is configured to open a sealable aperture, receive the pressure measurements in the wound dressing, calculate a rate of pressure decay, correlate the rate of pressure decay in the wound dressing to a wound dressing fluid absorbent capacity and other therapy parameters, and output the wound dressing fluid absorbent capacity and other therapy parameters to a remote electronic device.

Abstract: Substituted cyclohexyl chemical entities of Formula (I): wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders.

Abstract: A wound incision model includes an outer frame defining and opening and a simulated tissue disposed at least partially within the opening. The simulated tissue includes a body and a simulated wound. The simulated wound is disposed at least partially within the body. The simulated wound includes an aperture extending through the body from a first surface of the body to a second surface of the body. The simulated wound is configured to deform in response to a negative pressure applied across the simulated wound.

Abstract: A negative pressure wound therapy (NPWT) device includes a canister, a pump, a filter, and a control unit. The canister is configured to collect wound exudate from a wound site. The pump is fluidly coupled to the canister and configured to draw a vacuum within the canister by pumping air out of the canister. The filter is positioned between the canister and the pump such that the air pumped out of the canister passes through the filter in a first direction. The control unit is configured to operate the pump and to purge the filter by causing airflow through the filter in a second direction, opposite the first direction.

Abstract: One implementation of the present disclosure is a negative pressure wound therapy (NPWT) device. The NPWT device is configured to perform NPWT and includes a battery configured to supply the NPWT device with power, a pump configured to receive power from the battery and to produce a vacuum at a setpoint pressure to perform the NPWT, a user interface configured to provide alerts to a user, and a controller configured to receive power from the battery and to adjust the setpoint pressure of the pump. The controller is configured to operate the NPWT device in a standard therapy mode, a seal assist therapy mode, a pressure optimization mode, and a preservation mode of operation.

Abstract: A releasable connector for a negative pressure wound therapy system having a drape and a tube includes a base and a tube fitting. The base is configured to be coupled to the drape such that a substantially air-tight seal is formed between the base and the drape. The base includes a base locking member. The tube fitting is configured to be coupled to the tube such that a substantially air-tight seal is formed between the tube fitting and the tube. The tube fitting includes a tube locking member. The tube fitting is further configured to be selectively coupled to the base through an interaction between the tube locking member and the base locking member such that a substantially air-tight seal is formed between the tube fitting and the base.

Abstract: A pump generates a vacuum at a wound site via first tubing. A negative pressure circuit is defined by a canister, the first tubing and the wound site. A controller of a therapy device operates the pump to apply a first negative pressure to the entirety of the negative pressure circuit, following which ambient air is allowed to flow into the negative pressure circuit. The controller also operates the pump to apply a second negative pressure to a selected portion of the negative pressure circuit exclusive of the wound site, following which ambient air is allowed to flow into the selected portion. A quantity of fluid to be delivered to the wound site via a second tubing is determined by comparing measured parameters related to the flow of air into the negative pressure circuit to parameters measured with respect to the flow of air into the selected portion.

Abstract: A wound treatment system for treating a surgical wound includes a dressing. The dressing includes a manifold layer and an absorbent pouch assembly coupled to the manifold layer. The absorbent pouch assembly includes an absorbent material contained within a pouch. The dressing also includes a drape coupled to the absorbent pouch assembly and configured to be sealable over the surgical wound. The absorbent pouch assembly is positioned between the drape and the manifold layer. The wound treatment system also includes a pump fluidly communicable with the dressing and configured to draw a negative pressure at the manifold layer. The manifold layer is configured to substantially prevent medial collapse of the manifold layer under the negative pressure.

Abstract: A wound therapy system includes a single conduit fluidly connecting a wound site to a. removed fluid canister. A negative pressure circuit is defined by the wound site, the conduit, the removed fluid canister and tubing extending between the removed fluid canister and a pneumatic pump that applies negative pressure to the negative pressure circuit. A method of operating the wound therapy system includes profiling and benchmarking pressure decay within the negative pressure circuit against previous and/or expected pressure decay to identify any new or sudden anomalies that occur during the operation of the wound therapy system. The wound therapy system may additionally alert a user to such anomalous operation of the wound therapy system and/or identify and alert a user to an underlying cause (e.g, blockage and/or leak, etc.) that is responsible for the anomalous readings.

Abstract: A dressing includes an evaporative film layer having a wound-facing side and a non-wound¬ facing side. The evaporative film layer has a high moisture vapor transfer rate. The dressing includes a carrier film layer coupled to the non-wound-facing side of the evaporative film layer. A plurality of holes extends through the carrier film layer. The dressing includes a superab sorbent layer coupled to the wound-facing side of the evaporative film layer and a wicking layer coupled to the superab sorbent layer. The superab sorbent layer is positioned between the wicking layer and the evaporative film layer. The wicking layer is configured to wick fluid from a wound, the superab sorbent layer is configured to absorb fluid from the wicking layer, and the evaporative film layer and the carrier film layer allow evaporation of fluid from the superabsorbent layer through the holes. The carrier film layer provides structural support to the evaporative film layer.

Abstract: Substituted cyclohexyl chemical entities of Formula (I): wherein Ra, G, and Rb have any of the values described herein, and compositions comprising such chemical entities; methods of making them; and their use in a wide range of methods, including metabolic and reaction kinetic studies; detection and imaging techniques; radioactive therapies; modulating and treating disorders mediated by nociceptin activity or dopamine signaling; treating neurological disorders, neurodegenerative diseases, depression, and schizophrenia; enhancing the efficiency of cognitive and motor training; and treating peripheral disorders, including renal, respiratory, gastrointestinal, liver, genitourinary, metabolic, and inflammatory disorders.

Abstract: A combination hanger arm extension and pump cover device can be used with an instillation unit. The device includes a body portion that has a first end and a second end. A hook extends from the first end, and a tab extends from the body proximate the hook. A panel is disposed proximate the second end. A substantially rectangular sleeve extends at least partially through the body. The sleeve is disposed between the first and second end.

Abstract: Skin graft harvesting systems and methods are disclosed that utilize sensors to automate the harvesting of skin grafts or assist a user in deciding when the skin graft is ready to be harvested. Such systems and methods can reduce the burden of visual observation and ensure greater reliability and consistency of the grafts. The invention is particularly useful with harvesters that rely upon suction and/or heating to raise a plurality of small or “micro” blisters simultaneously.