Abstract: The invention is directed to systems, methods and computer program products for data integration. An exemplary method includes receiving a data record at a system, comparing the received data record with an existing data record, determining a level of match between the received data record and the existing data record, and in response to determining the level of match is equal to or greater than a first threshold level and is less than or equal to a second threshold level, processing the data, wherein the second threshold level is greater is than the first threshold level. Additionally, the exemplary method includes mapping the received data record to a database accessible to the system.

Abstract: Embodiments presented in this disclosure generally relate to an electro-optic device that includes one or more modulator portions and a terminator portion. Each modulator portion is disposed along a propagation path of an optical signal and includes a respective first doped region and one or more coupled first electrical contacts. Each modulator portion operates to modulate an optical signal propagating through the first doped region using first electrical signals applied to the electrical contacts. The terminator portion is disposed along the propagation path and proximate to at least one modulator portions, and operates to mitigate effects of droop on the propagating optical signal.

Abstract: Systems, apparatus, and methods are disclosed for using a deduplication index, a centralized cache repository, and a data mapping mechanism to detect and synchronize changes to deduplicated data objects stored in two or more third party databases. The disclosed systems, apparatus, and methods can maintain, in a deduplication index, a two-way mapping between one or more data object references and a datagram which uniquely identifies the real-world entity represented by said data object; maintain, in the centralized cache repository, two temporal states, one including current information, the other including previously-synchronized information. The disclosed systems, apparatus, and methods can also implement the data mapping mechanism to determine corresponding data objects in other systems when one or more data objects have apparent changes when compared with the centralized cache repository, and apply a given configuration in order to synchronize the current temporal states of all such data objects.

Abstract: High resolution protein A chromatography employing a chaotropic agent and pH gradient or pH step elution buffer results in improved peak resolution between closely related molecular species. Bispecific antibodies containing a protein A-binding-ablating substitution CH3 domain paired with a protein A-binding CH3 domain are separated with high peak resolution from monospecific antibodies containing a protein A-binding-ablating substituted CH3 domain paired with the protein A-binding-ablating substituted CH3 domain and monospecific antibodies containing a protein A-binding CH3 domain paired with the protein A-binding CH3 domain. Useful chaotropic agents include magnesium chloride and calcium chloride.

Abstract: A tinnitus method and device for providing relief to a person suffering from the disturbing effects of tinnitus is described. The method can be implemented entirely in software to spectrally modify an audio signal in accordance with a predetermined masking algorithm which modifies the intensity of the audio signal at selected frequencies. A predetermined masking algorithm is described which provides intermittent masking of the tinnitus wherein, at a comfortable listening level, during peaks of the audio signal the tinnitus is completely obscured, whereas during troughs the perception of the tinnitus occasionally emerges. In practice it has been found that such intermittent masking provides an immediate sense of relief, control and relaxation for the person, whilst enabling sufficient perception of the tinnitus for habituation and long term treatment to occur. Advantageously the predetermined masking algorithm is specifically tailored to the audiometric configuration of the person.

Abstract: A leading edge for use as a leading edge reinforcement on a blade or airfoil part. The leading edge has a main body that includes two leg sections. A metal deposition layer is applied to the main body to form the outer end portion of the leading edge. The main body can be formed of one or more pieces.

Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Abstract: A label and method for applying same. The label has a remaining portion having a front face, a back face, and an adhesive. The label also has a detachable portion removably coupled to the remaining portion via a weakened connection. The detachable portion has a front face, a back face, and a non-adhesive. Thus, a consumer can remove the detachable portion from the remaining portion via the weakened connection. The method includes obtaining the label, applying an adhesive, applying a non-adhesive, and affixing the label to the product whereby the detachable portion of the label can be detached.

Abstract: Systems, methods, and apparatus for recording time delayed broadband content are provided. Desired content to be recorded may be identified by a programming processing component configured to receive broadband content output by a service provider. A channel associated with the desired content and an amount of delay associated with the channel may be determined. Based at least in part upon the determined amount of delay, the recording of the desired content may be scheduled by the programming processing component.

Abstract: The invention relates generally to macrocyclic compounds and their therapeutic use. More particularly, the invention relates to macrocyclic compounds that modulate the activity of inhibitors of apoptosis (IAPs) and/or are useful in the treatment of medical conditions, such as cancer.

Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined herein. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.

Abstract: A method is presented. The method comprises identifying a desired shape of a ply on a tool, in which the ply has a fiber orientation; identifying a cut shape for the ply, in which the cut shape is different than the desired shape; cutting a composite prepreg ply to have the cut shape, the composite prepreg ply having the fiber orientation; using a deformable carrier to apply the composite prepreg ply having the cut shape to the tool such that the composite prepreg ply has the desired shape on the tool.

Abstract: Composite prepreg is laid up over a tool by placing prepreg material on a carrier film and using the carrier film to apply the prepreg material to the tool. The prepreg is conformed to contours of the tool by deforming the carrier film.

Abstract: A tinnitus method and device for providing relief to a person suffering from the disturbing effects of tinnitus is described. The method can be implemented entirely in software to spectrally modify an audio signal in accordance with a predetermined masking algorithm which modifies the intensity of the audio signal at selected frequencies. A predetermined masking algorithm is described which provides intermittent masking of the tinnitus wherein, at a comfortable listening level, during peaks of the audio signal the tinnitus is completely obscured, whereas during troughs the perception of the tinnitus occasionally emerges. In practice it has been found that such intermittent masking provides an immediate sense of relief, control and relaxation for the person, whilst enabling sufficient perception of the tinnitus for habituation and long term treatment to occur. Advantageously the predetermined masking algorithm is specifically tailored to the audiometric configuration of the person.

Abstract: A tinnitus method and device for providing relief to a person suffering from the disturbing effects of tinnitus is described. The method can be implemented entirely in software to spectrally modify an audio signal in accordance with a predetermined masking algorithm which modifies the intensity of the audio signal at selected frequencies. A predetermined masking algorithm is described which provides intermittent masking of the tinnitus wherein, at a comfortable listening level, during peaks of the audio signal the tinnitus is completely obscured, whereas during troughs the perception of the tinnitus occasionally emerges. In practice it has been found that such intermittent masking provides an immediate sense of relief, control and relaxation for the person, while enabling sufficient perception of the tinnitus for habituation and long term treatment to occur. Advantageously the predetermined masking algorithm is specifically tailored to the audiometric configuration of the person.

Abstract: Disclosed herein are macrocyclic compounds and methods for their synthesis and use. In particular, macrocyclic compounds are disclosed that modulate the activity of tumor necrosis factor alpha and/or are useful in the treatment of medical conditions, such as, rheumatoid arthritis, psoriasis, and asthma.

Abstract: Compounds and pharmaceutically acceptable salts of the compounds are disclosed, wherein the compounds have the structure of Formula I as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.