Patents by Inventor Benjamin B. Lim

Benjamin B. Lim has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Phosphonoalkyl phenylalanine compounds suitably protected for use in peptide synthesis
    Patent number: 5475129
    Abstract: The disclosure is concerned with providing phosphonic acid-containing derivatives of phenylalanine and optically active isomers thereof, which are functionalized in a manner which makes them suitable for facile incorporation into peptides using standard solid-phase or solution-phase techniques.
    Type: Grant
    Filed: June 8, 1993
    Date of Patent: December 12, 1995
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Terrence R. Burke, Jr., Mark S. Smyth, Benjamin B. Lim
  • Process of making benzylic .alpha.,.alpha.-diflurophosphonates from benzylic .alpha.-ketophosphorates
    Patent number: 5264607
    Abstract: The disclosure is concerned with providing phosphonic acid-containing derivatives of phenylalanine and optically active isomers thereof, which are functionalized in a manner which makes them suitable for facile incorporation into peptides using standard solid-phase or solution-phase techniques. The disclosure is also concerned with providing an advantageous one-step reaction method for preparing benzylic .alpha.,.alpha.-difluorophosphonates from corresponding benzylic ketophosphonates.
    Type: Grant
    Filed: June 12, 1992
    Date of Patent: November 23, 1993
    Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
    Inventors: Terrence R. Burke, Jr., Benjamin B. Lim, Mark S. Smyth
  • Phosphonoalkyl phenylalanine compounds suitably protected for use in peptide synthesis
    Patent number: 5200546
    Abstract: There are disclosed novel compounds of the formula: ##STR1## wherein, x is --CH.sub.2 --, --CHF--, --CF.sub.2, --CHOH-- or --C(O)--;R.sup.6 is hydrogen, benzyl, pentafluorophenyl, nitrophenyl, 1-benzotriazolyl or 1-succinimidoyl;Fmoc is 9-fluorenylmethyloxycarbonyl; and* indicates a chiral carbon atom.The Formula (I) compounds are useful in synthesizing peptides. There are also disclosed novel synthesis methods which include the step of hydrogenating a compound of the Formula ##STR2## wherein R.sup.4 and R.sup.5 are C.sub.1-8 lower alkyl, to give a compound of the formula ##STR3## wherein R.sup.4 and R.sup.5 are as defined above. The compounds of formula (II) are useful as intermediates in preparing certain formula (I) compounds.
    Type: Grant
    Filed: September 30, 1991
    Date of Patent: April 6, 1993
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Terrence R. Burke, Jr., Benjamin B. Lim