Abstract: A ground treatment apparatus including a holding device held on a support device, a plurality of injection elements disposed on the holding device, a fluid providing device in fluidic connection with the plurality of injection elements, a lifting device for inserting the plurality of injection elements into the ground and to extract the plurality of injection elements from the ground, a plurality of fluid containers in fluidic connection with the fluid providing device for the supply of fluid and a valve device having a plurality of outlet valves. The apparatus further including preassembled injection units, a respective injection unit comprising a fluid container, an outlet valve and an injection element.

Abstract: A ground treatment apparatus comprises a support device, injection elements, a fluid providing device that is fluidically connected to the injection elements, a drive device by which the injection elements are on the one hand lowerable and raisable in relation to the support device and on the other movable along a working direction of the ground treatment apparatus.

Abstract: The invention relates to a ground treatment apparatus for loosening ground, in particular in the case of ground with grass growth, specifically ground of sport or leisure facilities, comprising a support device and a holding device held thereon having a plurality of injection elements, a fluid providing device which is in fluidic connection with the injection elements, as well as a lifting device by way of which the injection elements are insertible into the ground and are extractable therefrom.

Abstract: A ground treatment apparatus comprises a support device, injection elements, a fluid providing device that is fluidically connected to the injection elements, a drive device by which the injection elements are on the one hand lowerable and raisable in relation to the support device and on the other movable along a working direction of the ground treatment apparatus.

Abstract: Stem cell exosome-containing compositions are provided, along with methods for their preparation and use for repair of soft tissue damage including treatment of skin conditions and periodontitis. The compositions provided contain isolated stem cell exosomes having increased levels of heat shock stress-response molecules. Uses of the exosome-containing compositions include treating a wound, a burn, a burn resulting from radiation treatment, a discoloration, a scar, and a keloid.

Abstract: Improved stem cell exosome-containing compositions are provided, along with methods for their preparation and use for regulating skin condition. The compositions provided contain isolated stem cell exosomes having increased levels of heat shock stress-response molecules. Uses of the exosome-containing compositions for regulating human skin include inducing increased skin integrity by cell renewal, enhancing water content or moisture of skin, reducing trans epidermal water loss, skin flaking, and scaling, improving skin thickness, enhancing skin tensile properties, reducing the appearance of dermal fine lines and wrinkles, improving skin texture, reducing skin pores size, enhancing skin smoothness, improving skin age spots, improving skin tone, and improving the appearance of scars and skin abrasions.

Abstract: The present invention relates to methods and antagonist compounds for modulating androgen receptor activity. The invention includes a method for identifying molecules that bind to a coactivator binding site of a receptor in the androgen receptor family. Also included is a cocrystal of an androgen receptor ligand binding domain complexed with a ligand and a coactivator. The invention further includes a method for inhibiting androgen receptor activity in a mammal, thereby facilitating treatment of diseases such as prostate cancer.

Abstract: The present invention relates to methods and antagonist compounds for modulating androgen receptor activity. The invention includes a method for identifying molecules that bind to a coactivator binding site of a receptor in the androgen receptor family. Also included is a cocrystal of an androgen receptor ligand binding domain complexed with a ligand and a coactivator. The invention further includes a method for inhibiting androgen receptor activity in a mammal, thereby facilitating treatment of diseases such as prostate cancer.

Abstract: Peptides which bind a cellular (surface or intracellular) receptor, such as a nuclear receptor, may be identified by screening a combinatorial peptide library presented in the form of cells each of which coexpress one member peptide and the receptor, together with a signal producing system for reporting binding. A “two-hybrid” assay is of particular interest. The screen may be carried out in the presence of a ligand, in particular, an exogenous ligand. If this screening is carried out for a plurality of different receptor conformations, then this library screening will also serve to identify conformation-specific peptides for the receptor, which may then be used in a panel for “fingerprinting” query compounds as to their ability to interact with the receptor in the presence of each of the panel peptides. These fingerprints may be compared to those of reference compounds with known biological activities mediated by that receptor.

Abstract: Peptides which bind a cellular (surface or intracellular) receptor, such as a nuclear receptor, may be identified by screening a combinatorial peptide library presented in the form of cells each of which coexpress one member peptide and the receptor, together with a signal producing system for reporting binding. A “two-hybrid” assay is of particular interest. The screen may be carried out in the presence of a ligand, in particular, an exogenous ligand. If this screening is carried out for a plurality of different receptor conformations, then this library screening will also serve to identify conformation-specific peptides for the receptor, which may then be used in a panel for “fingerprinting” query compounds as to their ability to interact with the receptor in the presence of each of the panel peptides. These fingerprints may be compared to those of reference compounds with known biological activities mediated by that receptor.