Patents by Inventor Benjamin C. BLUM

Benjamin C. BLUM has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • High pH protein refolding methods
    Patent number: 11345722
    Abstract: Provided herein are methods for refolding denatured protein (e.g., from inclusion bodies) that do not require the use of a denaturing agent. Exemplary methods use a high pH for solubilizing denatured protein, followed by a decrease in pH for refolding the proteins.
    Type: Grant
    Filed: July 31, 2018
    Date of Patent: May 31, 2022
    Assignee: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Cristopher Hollander, Benjamin C. Blum
  • Tangential flow filtration based protein refolding methods
    Patent number: 11053278
    Abstract: Provided herein are methods for refolding proteins that are denatured. Exemplary methods comprise solubilizing the denatured protein with a denaturing agent, e.g., a chaotropic agent, and renaturing the protein using a buffer exchanging system, e.g., tangential flow filtration (TFF).
    Type: Grant
    Filed: December 5, 2018
    Date of Patent: July 6, 2021
    Assignee: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Benjamin C. Blum, Christopher Hollander
  • TANGENTIAL FLOW FILTRATION BASED PROTEIN REFOLDING METHODS
    Publication number: 20190169229
    Abstract: Provided herein are methods for refolding proteins that are denatured. Exemplary methods comprise solubilizing the denatured protein with a denaturing agent, e.g., a chaotropic agent, and renaturing the protein using a buffer exchanging system, e.g., tangential flow filtration (TFF).
    Type: Application
    Filed: December 5, 2018
    Publication date: June 6, 2019
    Inventors: Benjamin C. BLUM, Cristopher HOLLANDER
  • HIGH PH PROTEIN REFOLDING METHODS
    Publication number: 20190077828
    Abstract: Provided herein are methods for refolding denatured protein (e.g., from inclusion bodies) that do not require the use of a denaturing agent. Exemplary methods use a high pH for solubilizing denatured protein, followed by a decrease in pH for refolding the proteins.
    Type: Application
    Filed: July 31, 2018
    Publication date: March 14, 2019
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Cristopher HOLLANDER, Benjamin C. BLUM
  • Tangential flow filtration based protein refolding methods
    Patent number: 10183967
    Abstract: Provided herein are methods for refolding proteins that are denatured. Exemplary methods comprise solubilizing the denatured protein with a denaturing agent, e.g., a chaotropic agent, and renaturing the protein using a buffer exchanging system, e.g., tangential flow filtration (TFF).
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: January 22, 2019
    Assignee: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Benjamin C. Blum, Cristopher Hollander
  • High pH protein refolding methods
    Patent number: 10065987
    Abstract: Provided herein are methods for refolding denatured protein (e.g., from inclusion bodies) that do not require the use of a denaturing agent. Exemplary methods use a high pH for solubilizing denatured protein, followed by a decrease in pH for refolding the proteins.
    Type: Grant
    Filed: February 11, 2014
    Date of Patent: September 4, 2018
    Assignee: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Cristopher Hollander, Benjamin C. Blum
  • HIGH PH PROTEIN REFOLDING METHODS
    Publication number: 20160002287
    Abstract: Provided herein are methods for refolding denatured protein (e.g., from inclusion bodies) that do not require the use of a denaturing agent. Exemplary methods use a high pH for solubilizing denatured protein, followed by a decrease in pH for refolding the proteins.
    Type: Application
    Filed: February 11, 2014
    Publication date: January 7, 2016
    Inventors: Cristopher HOLLANDER, Benjamin C. Blum
  • TANGENTIAL FLOW FILTRATION BASED PROTEIN REFOLDING METHODS
    Publication number: 20150376229
    Abstract: Provided herein are methods for refolding proteins that are denatured. Exemplary methods comprise solubilizing the denatured protein with a denaturing agent, e.g., a chaotropic agent, and renaturing the protein using a buffer exchanging system, e.g., tangential flow filtration (TFF).
    Type: Application
    Filed: February 11, 2014
    Publication date: December 31, 2015
    Applicant: BRISTOL-MYERS SQUIBB COMPANY
    Inventors: Benjamin C. BLUM, Cristopher Hollander