Patents by Inventor Benjamin Cacace

Benjamin Cacace has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220323300
    Abstract: A biocontainer having a first film, the film having an interior and exterior side; articulating elements disposed on or within the first film, the articulating elements comprising at least one a folded hinge, a sealed joint, a thinned pathway, a bowed path, an embedded polymeric or metallic cylindrical fiber or rod; and a second film, optionally comprising articulating elements, joined to the first film, to form a biocontainer having a closed volume, wherein the articulating elements permit the biocontainer to expand and collapse along the articulating elements.
    Type: Application
    Filed: September 9, 2020
    Publication date: October 13, 2022
    Inventors: Shannon Cleveland, Marina Varlamova, John Saragosa, David DeCoste, Benjamin Cacace, Daniel Lamothe, George Gagne, James Dee, Wilson Moya, Stefano Berti Perez
  • Patent number: 10449517
    Abstract: Chromatography media including a high surface area thermoplastic porous nanofiber and an ion-exchange ligand functionality on the surface of the fiber. The porous nanofibers display a convoluted structure that is comprised of discrete bundles of highly entangled nanofibrils that may be fibrillated or ridged. The porous fibers can be prepared through the extraction of a dissolvable mineral or polymeric porogen that is embedded into the fiber during its manufacture in a melt extrusion process.
    Type: Grant
    Filed: August 19, 2015
    Date of Patent: October 22, 2019
    Assignee: EMD Millipore Corporation
    Inventors: John Paul Amara, John Boyle, David Yavorsky, Benjamin Cacace
  • Patent number: 9816901
    Abstract: The invention relates to a liquid sample preparation device such as a disposable, collapsible, flexible polymeric bag containing an adsorptive curtain of a functionalized shaped polymeric fiber bed for the direct capture of biomolecules from liquid samples. The functionalized shaped polymeric fiber bed includes fibrillated, ridged or winged-shaped fiber structures that significantly increases the surface area of the fiber resulting in enhanced separation, retention and/or purification of liquid samples containing biomolecules of interest as the liquid samples contact the adsorptive curtain of functionalized shaped fibers. Liquid samples include unclarified liquid feeds or other liquids containing one or more biomolecules of interest, including, but not limited to vaccines, recombinant proteins, cells, stem cells, monoclonal antibodies (mAbs), proteins, antibody, peptides, oligopeptides, nucleic acids, oligonucleotides, RNA, DNA, oligosaccharides and polysaccharides.
    Type: Grant
    Filed: December 13, 2013
    Date of Patent: November 14, 2017
    Assignee: EMD Millipore Corporation
    Inventor: Benjamin Cacace
  • Publication number: 20170165638
    Abstract: Chromatography media including a high surface area thermoplastic porous nanofiber and an ion-exchange ligand functionality on the surface of the fiber. The porous nanofibers display a convoluted structure that is comprised of discrete bundles of highly entangled nanofibrils that may be fibrillated or ridged. The porous fibers can be prepared through the extraction of a dissolvable mineral or polymeric porogen that is embedded into the fiber during its manufacture in a melt extrusion process.
    Type: Application
    Filed: August 19, 2015
    Publication date: June 15, 2017
    Inventors: John Paul Amara, John Boyle, David Yavorsky, Benjamin Cacace
  • Publication number: 20150352465
    Abstract: Adsorptive media for chromatography, particularly ionexchange chromatography, derived from a shaped fiber, useful for purifying viruses. In certain embodiments, the functionalized shaped fiber presents a fibrillated or ridged structure which greatly increases the surface area of the fibers when compared to ordinary fibers. Surface pendant functional groups can be added that provides ion-exchange functionality to the high surface area fibers. This pendant functionality is useful for the ion-exchange chromatographic purification of viruses, such as influenza.
    Type: Application
    Filed: January 3, 2014
    Publication date: December 10, 2015
    Inventors: John Amara, Benjamin Cacace, David Yavorsky, John Boyle
  • Publication number: 20150292991
    Abstract: The invention relates to a liquid sample preparation device such as a disposable, collapsible, flexible polymeric bag containing an adsorptive curtain of a functionalized shaped polymeric fiber bed for the direct capture of biomolecules from liquid samples. The functionalized shaped polymeric fiber bed includes fibrillated, ridged or winged-shaped fiber structures that significantly increases the surface area of the fiber resulting in enhanced separation, retention and/or purification of liquid samples containing biomolecules of interest as the liquid samples contact the adsorptive curtain of functionalized shaped fibers. Liquid samples include unclarified liquid feeds or other liquids containing one or more biomolecules of interest, including, but not limited to vaccines, recombinant proteins, cells, stem cells, monoclonal antibodies (mAbs), proteins, antibody, peptides, oligopeptides, nucleic acids, oligonucleotides, RNA, DNA, oligosaccharides and polysaccharides.
    Type: Application
    Filed: December 13, 2013
    Publication date: October 15, 2015
    Inventor: Benjamin Cacace