Patents by Inventor Benjamin Chien

Benjamin Chien has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10646572
    Abstract: The present invention provides for a stabilized biodegradable polymeric composition useful as a controlled release delivery system for peptide agents. The compositions of the present invention comprise a) a beneficial salt of a luteinizing hormone releasing hormone (LHRH) analogue formed with a strong acid that minimizes or prevents the interaction/reaction between the LHRH and the polymer in an organic solution; b) a biodegradable polymer; c) a pharmaceutically acceptable organic solvent; and d) optionally one or more excipients. The present invention also relates to a method of manufacturing and a method of use thereof.
    Type: Grant
    Filed: April 5, 2019
    Date of Patent: May 12, 2020
    Assignee: Foresee Pharmaceuticals Co., Ltd.
    Inventors: Yuhua Li, Benjamin Chien
  • Publication number: 20190360830
    Abstract: Presented are techniques of identifying, processing and displaying data point clusters associated with map information in an efficient manner Methods and systems are disclosed which process map information to identify clusters of requested data points for display, based on iterative clustering and filtering of the data points. Methods and systems are also disclosed which generate polygons representing the clusters. The amount of data to be processed and/or displayed can be reduced, without loss of any associated information content in a displayed map.
    Type: Application
    Filed: August 6, 2019
    Publication date: November 28, 2019
    Inventors: Steve Chien, Mark Yinan Li, Marc Andreas Schaub, Benjamin James Anderson, James Aspinall, Zhou Bailiang, Ruwen Hess
  • Patent number: 10415987
    Abstract: Presented are techniques of identifying, processing and displaying data point clusters (850, 851) associated with map information (200) in an efficient manner. Methods and systems are disclosed which process map information (200) to identify clusters (850, 851) of requested data points for display (1020), based on iterative clustering and filtering of the data points. Methods and systems are also disclosed which generate polygons (1860, 1861, 1901-05) representing the clusters. The amount of data to be processed and/or displayed can be reduced, without loss of any associated information content in a displayed map.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: September 17, 2019
    Assignee: Google LLC
    Inventors: Steve Chien, Mark Yinan Li, Marc Schaub, Benjamin Anderson, James Aspinall, Zhou Bailiang, Ruwen Hess
  • Publication number: 20190231881
    Abstract: The present invention provides for a stabilized biodegradable polymeric composition useful as a controlled release delivery system for peptide agents. The compositions of the present invention comprise a) a beneficial salt of a luteinizing hormone releasing hormone (LHRH) analogue formed with a strong acid that minimizes or prevents the interaction/reaction between the LHRH and the polymer in an organic solution; b) a biodegradable polymer; c) a pharmaceutically acceptable organic solvent; and d) optionally one or more excipients. The present invention also relates to a method of manufacturing and a method of use thereof.
    Type: Application
    Filed: April 5, 2019
    Publication date: August 1, 2019
    Inventors: Yuhua LI, Benjamin CHIEN
  • Patent number: 10251956
    Abstract: The present invention provides for a stabilized biodegradable polymeric composition useful as a controlled release delivery system for peptide agents. The compositions of the present invention comprise a) a beneficial salt of a luteinizing hormone releasing hormone (LHRH) analog formed with a strong acid that minimizes or prevents the interaction/reaction between the LHRH and the polymer in an organic solution; b) a biodegradable polymer; c) a pharmaceutically acceptable organic solvent; and d) optionally one or more excipients. The present invention also relates to a method of manufacturing and a method of use thereof.
    Type: Grant
    Filed: July 27, 2017
    Date of Patent: April 9, 2019
    Assignee: Foresee Pharmaceuticals Co., Ltd.
    Inventors: Yuhua Li, Benjamin Chien
  • Publication number: 20180050108
    Abstract: The present invention provides for a stabilized biodegradable polymeric composition useful as a controlled release delivery system for peptide agents. The compositions of the present invention comprise a) a beneficial salt of a luteinizing hormone releasing hormone (LHRH) analogue formed with a strong acid that minimizes or prevents the interaction/reaction between the LHRH and the polymer in an organic solution; b) a biodegradable polymer; c) a pharmaceutically acceptable organic solvent; and d) optionally one or more excipients. The present invention also relates to a method of manufacturing and a method of use thereof.
    Type: Application
    Filed: July 27, 2017
    Publication date: February 22, 2018
    Inventors: Yuhua Li, Benjamin Chien
  • Patent number: 9744207
    Abstract: The present invention provides for a stabilized biodegradable polymeric composition useful as a controlled release delivery system for peptide agents. The compositions of the present invention comprise a) a beneficial salt of a luteinizing hormone releasing hormone (LHRH) analog formed with a strong acid that minimizes or prevents the interaction/reaction between the LHRH and the polymer in an organic solution; b) a biodegradable polymer; c) a pharmaceutically acceptable organic solvent; and d) optionally one or more excipients. The present invention also relates to a method of manufacturing and a method of use thereof.
    Type: Grant
    Filed: January 13, 2017
    Date of Patent: August 29, 2017
    Assignee: Foresee Pharmaceuticals Co., Ltd.
    Inventors: Yuhua Li, Benjamin Chien
  • Publication number: 20170119842
    Abstract: The present invention provides for a stabilized biodegradable polymeric composition useful as a controlled release delivery system for peptide agents. The compositions of the present invention comprise a) a beneficial salt of a luteinizing hormone releasing hormone (LHRH) analogue formed with a strong acid that minimizes or prevents the interaction/reaction between the LHRH and the polymer in an organic solution; b) a biodegradable polymer; c) a pharmaceutically acceptable organic solvent; and d) optionally one or more excipients. The present invention also relates to a method of manufacturing and a method of use thereof.
    Type: Application
    Filed: January 13, 2017
    Publication date: May 4, 2017
    Inventors: Yuhua Li, Benjamin Chien
  • Patent number: 9572857
    Abstract: The present invention provides for a stabilized biodegradable polymeric composition useful as a controlled release delivery system for peptide agents. The compositions of the present invention comprise a) a beneficial salt of a peptide agent formed with a strong acid that minimizes or prevents the interaction/reaction between the peptide agent and the polymer in an organic solution; b) a biodegradable polymer; c) a pharmaceutically acceptable organic solvent; and d) optionally one or more excipients. The present invention also relates to a method of manufacturing and a method of use thereof.
    Type: Grant
    Filed: August 6, 2016
    Date of Patent: February 21, 2017
    Assignee: Foresee Pharmaceuticals Co., Ltd.
    Inventors: Yuhua Li, Benjamin Chien
  • Publication number: 20160331802
    Abstract: The present invention provides for a stabilized biodegradable polymeric composition useful as a controlled release delivery system for peptide agents. The compositions of the present invention comprise a) a beneficial salt of a peptide agent formed with a strong acid that minimizes or prevents the interaction/reaction between the peptide agent and the polymer in an organic solution; b) a biodegradable polymer; c) a pharmaceutically acceptable organic solvent; and d) optionally one or more excipients. The present invention also relates to a method of manufacturing and a method of use thereof.
    Type: Application
    Filed: August 6, 2016
    Publication date: November 17, 2016
    Inventors: Yuhua Li, Benjamin Chien
  • Patent number: 8840915
    Abstract: The present invention provides methods of forming a solid, biodegradable implant in-situ in a body by administering a liquid pharmaceutical composition comprising an effective amount of a biocompatible, water-insoluble, biodegradable polymer and an effective amount of a therapeutic peptide covalently modified with one or more lipophilic or amphiphilic moieties, which are dissolved or dispersed in a biocompatible, water-soluble organic solvent. This invention also provides related compositions and methods.
    Type: Grant
    Filed: May 25, 2012
    Date of Patent: September 23, 2014
    Assignee: Foresec Pharmaceuticals, LLC
    Inventors: Yuhua Li, Benjamin Chien
  • Patent number: 8586103
    Abstract: The present invention provides a novel liquid composition suitable for in-situ formation of a depot system to deliver a bioactive substance in a controlled manner. The composition of the present invention comprises: (a) a hydrophobic non-polymeric carrier material; (b) a water miscible biocompatible organic solvent that dissolves the hydrophobic non-polymeric material; (c) an ionic complex that is formed between an amphiphilic molecule and a bioactive substance having a net charge at neutral pH in water. The present invention also provides a method of manufacturing and use of the composition thereof.
    Type: Grant
    Filed: February 5, 2009
    Date of Patent: November 19, 2013
    Assignee: Foresee Pharmaceuticals, LLC
    Inventors: Yuhua Li, Andrew Guarino, Benjamin Chien
  • Publication number: 20130254389
    Abstract: A method and system for reporting website activity. According to an example embodiment, the system receives event-level data representing visitor activity on a client website, infers attribution of one or more metrics to at least one navigation entity based on the visitor activity, and provides reports based on the inferred attribution.
    Type: Application
    Filed: May 16, 2013
    Publication date: September 26, 2013
    Applicant: GOOGLE INC.
    Inventors: Jonathan Marc Heller, James Christopher Kim, Dwight Allen Merriman, Andrew Joel Erlichson, Benjamin Chien-wen Lee
  • Patent number: 8452865
    Abstract: A method and system for reporting website activity. According to an example embodiment, the system receives event-level data representing visitor activity on a client website, infers attribution of one or more metrics to at least one navigation entity based on the visitor activity, and provides reports based on the inferred attribution.
    Type: Grant
    Filed: March 6, 2008
    Date of Patent: May 28, 2013
    Assignee: Google Inc.
    Inventors: Jonathan Marc Heller, James Christopher Kim, Dwight Allen Merriman, Andrew Joel Erlichson, Benjamin Chien-wen Lee
  • Publication number: 20120237476
    Abstract: The present invention provides methods of forming a solid, biodegradable implant in-situ in a body by administering a liquid pharmaceutical composition comprising an effective amount of a biocompatible, water-insoluble, biodegradable polymer and an effective amount of a therapeutic peptide covalently modified with one or more lipophilic or amphiphilic moieties, which are dissolved or dispersed in a biocompatible, water-soluble organic solvent. This invention also provides related compositions and methods.
    Type: Application
    Filed: May 25, 2012
    Publication date: September 20, 2012
    Applicant: Foressee Pharmaceuticals, LLC
    Inventors: Yuhua LI, Benjamin CHIEN
  • Patent number: 8206735
    Abstract: The present invention provides methods of forming a solid, biodegradable implant in-situ in a body by administering a liquid pharmaceutical composition comprising an effective amount of a biocompatible, water-insoluble, biodegradable polymer and an effective amount of a therapeutic peptide covalently modified with one or more lipophilic or amphiphilic moieties, which are dissolved or dispersed in a biocompatible, water-soluble organic solvent. This invention also provides related compositions and methods.
    Type: Grant
    Filed: July 11, 2007
    Date of Patent: June 26, 2012
    Assignee: Foresee Pharmaceuticals, LLC
    Inventors: Yuhua Li, Benjamin Chien
  • Patent number: 7964219
    Abstract: The present invention provides compositions and methods for the controlled release delivery of one or more biologically active compounds to a subject. Specifically, the invention provides for a pharmaceutical composition for the controlled release delivery of biologically active compounds to a subject comprising: a) a complex of a biologically active compound having at least one basic functional group and a polyanion derived from hexahydroxycyclohexane having at least two negatively charged functional groups; and b) a pharmaceutically acceptable carrier comprising a biodegradable, water-insoluble polymer. By complexing a biologically active compound with a polyanion, the tight, stable complex may be incorporated into a long-acting dosage system having a more desired drug release curve over time than that is found in the prior art. The invention also provides the methods of making such compositions and the methods of use thereof.
    Type: Grant
    Filed: August 11, 2005
    Date of Patent: June 21, 2011
    Assignee: QPS, LLC
    Inventors: Yuhua Li, Benjamin Chien
  • Publication number: 20100034801
    Abstract: The present invention provides a novel liquid composition suitable for in-situ formation of a depot system to deliver a bioactive substance in a controlled manner. The composition of the present invention comprises: (a) a hydrophobic non-polymeric carrier material; (b) a water miscible biocompatible organic solvent that dissolves the hydrophobic non-polymeric material; (c) an ionic complex that is formed between an amphiphilic molecule and a bioactive substance having a net charge at neutral pH in water. The present invention also provides a method of manufacturing and use of the composition thereof.
    Type: Application
    Filed: February 5, 2009
    Publication date: February 11, 2010
    Applicant: QPS LLC
    Inventors: Yuhua Li, Andrew Guarino, Benjamin Chien
  • Patent number: D884910
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: May 19, 2020
    Assignee: AVATION MEDICAL, INC.
    Inventors: Jill F. Schiaparelli, Francis Paul Harrington, Serge Roux, Benjamin Zwillinger, Anna Christina Miller, Alireza Mashal, Joyce Chien Tu
  • Patent number: D885594
    Type: Grant
    Filed: February 26, 2019
    Date of Patent: May 26, 2020
    Assignee: AVATION MEDICAL, INC.
    Inventors: Jill F. Schiaparelli, Francis Paul Harrington, Serge Roux, Benjamin Zwillinger, Anna Christina Miller, Alireza Mashal, Joyce Chien Tu