Patents by Inventor Benjamin D. Ortiz

Benjamin D. Ortiz has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TCR(alpha)-LCR-derived gene regulatory cassettes
    Patent number: 10053708
    Abstract: A method of delivering a transgene to a cell is provided. The method uses a vector that contains a T-cell receptor alpha locus control region (TCR?LCR) derived gene regulatory cassette having fewer than 5.0-kb. The method delivers the transgene with spatiotemporally specific gene expression and silencing-prevention controls to a cell such that a predetermined subset of progeny cell-types express a gene product from the transgene. Other progeny of the cell diminish, or silence, the expression of the gene product.
    Type: Grant
    Filed: May 11, 2015
    Date of Patent: August 21, 2018
    Assignee: Research Foundation of the City University of New York
    Inventors: Benjamin D. Ortiz, Armin Lahiji
  • TCR(alpha)-LCR-DERIVED GENE REGULATORY CASSETTES
    Publication number: 20170240918
    Abstract: A method of delivering a transgene to a cell is provided. The method uses a vector that contains a T-cell receptor alpha locus control region (TCR?LCR) derived gene regulatory cassette having fewer than 5.0-kb. The method delivers the transgene with spatiotemporally specific gene expression and silencing-prevention controls to a cell such that a predetermined subset of progeny cell-types express a gene product from the transgene. Other progeny of the cell diminish, or silence, the expression of the gene product.
    Type: Application
    Filed: May 11, 2015
    Publication date: August 24, 2017
    Inventors: Benjamin D. Ortiz, Armin Lahiji
  • Enhancer sequences for late T cell expressed genes
    Patent number: 6448039
    Abstract: The present invention provides elements derived from a human RANTES promoter that induce expression of a heterologous coding sequence. The invention further provides expression vectors comprising the elements, and host cells comprising the expression vectors. The invention further provides methods of inducing the expression of a heterologous protein in a host.
    Type: Grant
    Filed: June 30, 1999
    Date of Patent: September 10, 2002
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Peter J. Nelson, Alan M. Krensky, Benjamin D. Ortiz