Patents by Inventor Benjamin D. Pless

Benjamin D. Pless has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 11793980
    Abstract: An intestinal attachment device is provided that includes an ingestible housing with a chamber having disposed therein a low-profile ribbon with a head that serves as a single attachment area for an anchor sized and configured to attach to the mucosal surface of an intestine. A disposable material is also disposed within the chamber and at least partially surrounds the ribbon. An anchor is disposed within the housing and is attached to the head of the low-profile ribbon. The anchor has a constrained and a non-constrained state and is sized and configured to attach to the mucosal surface of the intestine. The anchor is at least partially surrounded by a dissolvable material.
    Type: Grant
    Filed: August 31, 2020
    Date of Patent: October 24, 2023
    Assignee: CELERO SYSTEMS, INC.
    Inventors: Benjamin D. Pless, Daniel Bacher
  • Publication number: 20230053966
    Abstract: An ingestible medical device that includes an ingestible capsule. Within the ingestible capsule is a non-refillable drug dispenser containing a therapeutic agent. The capsule can also include a real-time clock. A controller within the capsule can be operatively connected to the drug dispenser and can include a memory module and a processor operable to execute a software application stored on the memory module to control the operation of the drug dispenser to administer the therapeutic agent according to a real-time schedule measured via the real-time clock. The ingestible medical device can also include an iontophoretic circuit or system for drug delivery as well as physiological sensors to detect the occurrence or worsening of a medical condition.
    Type: Application
    Filed: January 27, 2021
    Publication date: February 23, 2023
    Inventors: Benjamin D. Pless, Daniel Bacher
  • Publication number: 20210060318
    Abstract: An intestinal attachment device is provided that includes an ingestible housing with a chamber having disposed therein a low-profile ribbon with a head that serves as a single attachment area for an anchor sized and configured to attach to the mucosal surface of an intestine. A disposable material is also disposed within the chamber and at least partially surrounds the ribbon. An anchor is disposed within the housing and is attached to the head of the low-profile ribbon. The anchor has a constrained and a non-constrained state and is sized and configured to attach to the mucosal surface of the intestine. The anchor is at least partially surrounded by a dissolvable material.
    Type: Application
    Filed: August 31, 2020
    Publication date: March 4, 2021
    Inventors: Benjamin D. Pless, Daniel Bacher
  • Publication number: 20210060317
    Abstract: An opioid overdose rescue device is provided that includes an ingestible capsule. Within the ingestible capsule is a non-refillable drug dispenser comprising an opioid antidote and at least one sensor configured to detect at least one physiological parameter indicative of an opioid overdose. A controller is also contained within the ingestible capsule and is operatively coupled to the drug dispenser and the least one sensor. The controller is configured to receive a signal detected by the least one sensor of the at least one physiological parameter to actuate release of the opioid antidote from the drug dispenser into the intestine of the patient upon a determination that the at least one physiological parameter falls outside a threshold value or range for the at least one physiological parameter indicating that an opioid overdose has been detected.
    Type: Application
    Filed: August 31, 2020
    Publication date: March 4, 2021
    Inventors: Benjamin D. Pless, Daniel Bacher
  • Patent number: 10321866
    Abstract: Systems, methods and devices are disclosed for directing and focusing signals to the brain for neuromodulation and for directing and focusing signals or other energy from the brain for measurement, heat transfer and imaging. An aperture in the skull and/or a channel device implantable in the skull can be used to facilitate direction and focusing. Treatment and diagnosis of multiple neurological conditions may be facilitated with the disclosed systems, methods and devices.
    Type: Grant
    Filed: September 12, 2014
    Date of Patent: June 18, 2019
    Assignee: NeuroPace, Inc.
    Inventors: Benjamin D. Pless, Stephen T. Archer, Craig M. Baysinger, Barbara Gibb, Suresh Gurunathan, Bruce Kirkpatrick, Thomas K. Tcheng
  • Patent number: 10137312
    Abstract: In certain aspects, the present disclosure is directed to a method of improving a patient's recovery after a neuro-ischemic event. The method can include identifying a patient who has suffered a neuro-ischemic event, and stimulating, for a period of time, a parasympathetic structure in the patient's cranium before, during, and/or after the patient undergoes a task-oriented therapy to improve the patient's recovery.
    Type: Grant
    Filed: October 6, 2016
    Date of Patent: November 27, 2018
    Assignee: AUTONOMIC TECHNOLOGIES, INC.
    Inventors: Anthony V. Caparso, Benjamin D. Pless
  • Patent number: 10105091
    Abstract: Methods for intra-operatively monitoring nerve evoked potentials such as somatosensory nerve evoked potentials during a surgical procedure. The methods include orthodromic and antidromic monitoring of nerve evoked potentials. Monitoring includes navigating the surgical pathway to avoid insult to anatomical tissue, minimizing activation of sensory nerves that result in undesirable side effects in a patient, and determining the suitable location for placement of an implantable medical device.
    Type: Grant
    Filed: March 12, 2014
    Date of Patent: October 23, 2018
    Assignees: The Cleveland Clinic Foundation, Autonomic Technologies, Inc.
    Inventors: Francis A. Papay, Mike Hardage, Anthony V. Caparso, Benjamin D. Pless
  • Patent number: 9943690
    Abstract: An implantable neurostimulator system adapted to provide therapy for various neurological disorders is capable of varying therapy delivery strategies based on the context, physiological or otherwise, into which the therapy is to be delivered. Responsive and scheduled therapies can be varied depending on various sensor measurements, calculations, inferences, and device states (including elapsed times and times of day) to deliver an appropriate course of therapy under the circumstances.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: April 17, 2018
    Assignee: NeuroPace, Inc.
    Inventors: Benjamin D. Pless, Thomas K. Tcheng
  • Patent number: 9878160
    Abstract: An implantable neurostimulator system adapted to provide therapy for various neurological disorders is capable of varying therapy delivery strategies based on the context, physiological or otherwise, into which the therapy is to be delivered. Responsive and scheduled therapies can be varied depending on various sensor measurements, calculations, inferences, and device states (including elapsed times and times of day) to deliver an appropriate course of therapy under the circumstances.
    Type: Grant
    Filed: August 24, 2016
    Date of Patent: January 30, 2018
    Assignee: NeuroPace, Inc.
    Inventors: Benjamin D. Pless, Thomas K. Tcheng
  • Publication number: 20170281937
    Abstract: One aspect of the present disclosure relates to a method for treating a menopause-related condition in a subject. One step of the method can include inserting a therapy delivery device into a vessel of the subject. Next, the therapy delivery device can be advanced to a point substantially adjacent a target site of the sympathetic nervous system (SNS) that is associated with the menopause-related condition. The therapy delivery device can then be activated to deliver a therapy signal to the target site of the SNS in an amount and for a time sufficient to effect a change in sympathetic activity in the subject and thereby treat the menopause-related condition.
    Type: Application
    Filed: April 25, 2016
    Publication date: October 5, 2017
    Inventors: Benjamin D. Pless, Shannon Schuetz
  • Publication number: 20170203111
    Abstract: An interactive implantable medical device system includes an implantable medical device and a network-enabled external device capable of bi-directional communication and interaction with the implantable medical device. The external device is programmed to interact with other similarly-enabled devices. The system facilitates improved patient care by eliminating unnecessary geographic limitations on implantable medical device interrogation and programming, and by allowing patients, physicians, and other users to access medical records, history, and information and to receive status and care-related alerts and messages anywhere there is access to a communications network.
    Type: Application
    Filed: April 5, 2017
    Publication date: July 20, 2017
    Inventors: Benjamin D. PLESS, David R. FISCHELL, Barbara GIBB, Lisa GUZZO, Adrian R.M. UPTON
  • Patent number: 9662140
    Abstract: One aspect of the present disclosure relates to a surgical guidance tool configured to facilitate delivery of a neurostimulator to a target craniofacial region of a subject. The surgical guidance tool can include a main body, a securing mechanism, and an adjustable guide mechanism. The main body can have a distal end, a proximal end, and a longitudinal axis extending between the distal and proximal ends. The securing mechanism can be disposed at the distal end and configured to secure a neurostimulator delivery tool to the main body. The guide mechanism can be configured to temporarily mate with a bodily target location of the subject and facilitate positioning of the neurostimulator delivery tool about the target craniofacial region. The guide member can be slidably attached to the distal end and selectively translatable along the longitudinal axis of the main body.
    Type: Grant
    Filed: June 21, 2013
    Date of Patent: May 30, 2017
    Assignee: Autonomic Technologies, Inc.
    Inventors: Ryan Powell, Benjamin D. Pless
  • Patent number: 9649049
    Abstract: An interactive implantable medical device system includes an implantable medical device and a network-enabled external device capable of bi-directional communication and interaction with the implantable medical device. The external device is programmed to interact with other similarly-enabled devices. The system facilitates improved patient care by eliminating unnecessary geographic limitations on implantable medical device interrogation and programming, and by allowing patients, physicians, and other users to access medical records, history, and information and to receive status and care-related alerts and messages anywhere there is access to a communications network.
    Type: Grant
    Filed: November 10, 2015
    Date of Patent: May 16, 2017
    Assignee: NeuroPace, Inc.
    Inventors: Benjamin D. Pless, David R. Fischell, Barbara Gibb, Lisa Guzzo, Adrian R. M. Upton
  • Publication number: 20170095676
    Abstract: In certain aspects, the present disclosure is directed to a method of improving a patient's recovery after a neuro-ischemic event. The method can include identifying a patient who has suffered a neuro-ischemic event, and stimulating, for a period of time, a parasympathetic structure in the patient's cranium before, during, and/or after the patient undergoes a task-oriented therapy to improve the patient's recovery.
    Type: Application
    Filed: October 6, 2016
    Publication date: April 6, 2017
    Inventors: Anthony V. Caparso, Benjamin D. Pless
  • Patent number: 9597032
    Abstract: Described here are implantable devices and methods for monitoring physiological information relating to sleep. The implantable devices are generally designed to include at least one sensor for sensing physiological information, a processor for processing the physiological information using low computational power to detect a sleep stage, and a battery. The detected sleep stage information may then be used to indicate sleep quality, identify or monitor a medical condition, or guide treatment thereof.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: March 21, 2017
    Assignee: NeuroPace, Inc.
    Inventors: Felice Sun, Benjamin D. Pless, Barbara Gibb
  • Publication number: 20170021167
    Abstract: One aspect of the present disclosure relates to a method for treating a menopause-related condition in a subject. One step of the method can include inserting a therapy delivery device into a vessel of the subject. Next, the therapy delivery device can be advanced to a point substantially adjacent a target site of the sympathetic nervous system (SNS) that is associated with the menopause-related condition. The therapy delivery device can then be activated to deliver a therapy signal to the target site of the SNS in an amount and for a time sufficient to effect a change in sympathetic activity in the subject and thereby treat the menopause-related condition.
    Type: Application
    Filed: April 25, 2016
    Publication date: January 26, 2017
    Inventors: Benjamin D. Pless, Shannon Schuetz
  • Publication number: 20160367814
    Abstract: An implantable neurostimulator system adapted to provide therapy for various neurological disorders is capable of varying therapy delivery strategies based on the context, physiological or otherwise, into which the therapy is to be delivered. Responsive and scheduled therapies can be varied depending on various sensor measurements, calculations, inferences, and device states (including elapsed times and times of day) to deliver an appropriate course of therapy under the circumstances.
    Type: Application
    Filed: August 24, 2016
    Publication date: December 22, 2016
    Inventors: Benjamin D. PLESS, Thomas K. TCHENG
  • Publication number: 20160361547
    Abstract: An implantable neurostimulator system adapted to provide therapy for various neurological disorders is capable of varying therapy delivery strategies based on the context, physiological or otherwise, into which the therapy is to be delivered. Responsive and scheduled therapies can be varied depending on various sensor measurements, calculations, inferences, and device states (including elapsed times and times of day) to deliver an appropriate course of therapy under the circumstances.
    Type: Application
    Filed: August 24, 2016
    Publication date: December 15, 2016
    Inventors: Benjamin D. PLESS, Thomas K. TCHENG
  • Patent number: 9451891
    Abstract: An implantable neurostimulator system adapted to provide therapy for various neurological disorders is capable of varying therapy delivery strategies based on the context, physiological or otherwise, into which the therapy is to be delivered. Responsive and scheduled therapies can be varied depending on various sensor measurements, calculations, inferences, and device states (including elapsed times and times of day) to deliver an appropriate course of therapy under the circumstances.
    Type: Grant
    Filed: December 5, 2014
    Date of Patent: September 27, 2016
    Assignee: NeuroPace Inc.
    Inventors: Benjamin D. Pless, Thomas K. Tcheng
  • Publication number: 20160270817
    Abstract: One aspect of the present disclosure relates to a surgical guidance tool configured to facilitate delivery of a neurostimulator to a target craniofacial region of a subject. The surgical guidance tool can include a main body, a securing mechanism, and an adjustable guide mechanism. The main body can have a distal end, a proximal end, and a longitudinal axis extending between the distal and proximal ends. The securing mechanism can be disposed at the distal end and configured to secure a neurostimulator delivery tool to the main body. The guide mechanism can be configured to temporarily mate with a bodily target location of the subject and facilitate positioning of the neurostimulator delivery tool about the target craniofacial region. The guide member can be slidably attached to the distal end and selectively translatable along the longitudinal axis of the main body.
    Type: Application
    Filed: June 1, 2016
    Publication date: September 22, 2016
    Inventors: Ryan Powell, Benjamin D. Pless