Patents by Inventor Benjamin Daelken

Benjamin Daelken has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • METHODS AND AGENTS FOR IMPROVING TARGETING OF CD138 EXPRESSING TUMOR CELLS
    Publication number: 20090169570
    Abstract: Disclosed are immunoconjugates having specificity for CD138 that diminish adhesion of CD138 expressing tumor cells to stroma cells and methods of using the same. This diminished adhesion renders the tumor cells not only susceptible to the immunoconjugate, but also to other agents, in particular cytotoxic agents.
    Type: Application
    Filed: December 23, 2008
    Publication date: July 2, 2009
    Inventors: Benjamin Daelken, Christoph Uherek, Kenneth Anderson, Teru Hideshima, Christoph Bruecher
  • OPTIMIZED DNA AND PROTEIN SEQUENCE OF AN ANTIBODY TO IMPROVE QUALITY AND YIELD OF BACTERIALLY EXPRESSED ANTIBODY FUSION PROTEINS
    Publication number: 20090018079
    Abstract: Object matter of the invention is an optimized DNA sequence encoding the scFv(FRP5) antibody fragment. This novel sequence prevents the generation of the undesired by-product in the context of an scFv(FRP5)-ETA fusion protein, and possibly also other bacterially expressed scFv(FRP5)-containing fusion proteins. The DNA sequence of the scFv(FRP5) domain of scFv(FRP5)-ETA was modified by exchanging a distinct codon, thereby preventing an otherwise possible internal start of protein translation.
    Type: Application
    Filed: July 10, 2008
    Publication date: January 15, 2009
    Inventors: Winfried S. WELS, Benjamin Daelken, Sylvia E. Schwarz