Patents by Inventor Benjamin David Philpot

Benjamin David Philpot has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • UBE3A GENES AND EXPRESSION CASSETTES AND THEIR USE
    Publication number: 20220241434
    Abstract: This invention relates to polynucleotides comprising UBE3A open reading frame (ORF) sequences, vectors comprising the same, and methods of using the same for delivery of the ORF to a cell or a subject and to treat disorders associated with aberrant expression of a UBE3A gene or aberrant activity of a UBE3A gene product in the subject, such as Angelman Syndrome.
    Type: Application
    Filed: May 22, 2020
    Publication date: August 4, 2022
    Inventors: Benjamin David Philpot, Steven James Gray, Charles Shyng, Matthew Judson
  • Methods and compositions for unsilencing imprinted genes
    Patent number: 10301630
    Abstract: The present invention provides methods and compositions for inducing expression of Ube3a in a cell by contacting the cell with a topoisomerase inhibitor. Particular embodiments include a method of treating a genomic imprinting disorder, such as Angelman syndrome, in a subject by administering to the subject an effective amount of a topoisomerase inhibitor.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: May 28, 2019
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Benjamin David Philpot, Mark John Zylka, Bryan Leo Roth, John Arthur Allen, Hsien-Sung Huang
  • METHODS AND COMPOSITIONS FOR UNSILENCING IMPRINTED GENES
    Publication number: 20180016584
    Abstract: The present invention provides methods and compositions for inducing expression of Ube3a in a cell by contacting the cell with a topoisomerase inhibitor. Particular embodiments include a method of treating a genomic imprinting disorder, such as Angelman syndrome, in a subject by administering to the subject an effective amount of a topoisomerase inhibitor.
    Type: Application
    Filed: June 22, 2017
    Publication date: January 18, 2018
    Inventors: Benjamin David Philpot, Mark John Zylka, Bryan Lao Roth, John Arthur Allen, Hsien-Sung Huang
  • Methods and compositions for unsilencing imprinted genes
    Patent number: 9714427
    Abstract: The present invention provides methods and compositions for inducing expression of Ube3a in a cell by contacting the cell with a topoisomerase inhibitor. Particular embodiments include a method of treating a genomic imprinting disorder, such as Angelman syndrome, in a subject by administering to the subject an effective amount of a topoisomerase inhibitor.
    Type: Grant
    Filed: November 9, 2011
    Date of Patent: July 25, 2017
    Assignee: The University of North Carolina at Chapel Hill
    Inventors: Benjamin David Philpot, Mark John Zylka, Bryan Leo Roth, John Arthur Allen, Hsien-Sung Huang
  • Methods and Compositions for Unsilencing Imprinted Genes
    Publication number: 20130317018
    Abstract: The present invention provides methods and compositions for inducing expression of Ube3a in a cell by contacting the cell with a topoisomerase inhibitor. Particular embodiments include a method of treating a genomic imprinting disorder, such as Angelman syndrome, in a subject by administering to the subject an effective amount of a topoisomerase inhibitor.
    Type: Application
    Filed: November 9, 2011
    Publication date: November 28, 2013
    Inventors: Benjamin David Philpot, Mark John Zylka, Bryan Leo Roth, John Arthur Allen, Hsien-Sung Huang