Patents by Inventor Benjamin Demaree

Benjamin Demaree has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR THE TARGETING OF LPA
    Publication number: 20260152733
    Abstract: Provided herein are systems comprising Class 2, Type V CRISPR proteins and guide nucleic acids (gRNA) useful in the modification of a target nucleic acid of a lipoprotein (a) (LPA) gene. The systems are also useful for introduction into cells, for example eukaryotic cells. Also provided are methods for treating subjects having a LPA-related disease and methods for optimizing the encoding sequences.
    Type: Application
    Filed: September 29, 2025
    Publication date: June 4, 2026
    Inventors: Dena LEEMAN, Sarah DENNY, Sean HIGGINS, Brett T. STAAHL, Oleh KRUPA, Benjamin DEMAREE, Matthew HARMS, Benjamin OAKES, Addison WRIGHT
  • Compositions and methods for the targeting of PCSK9
    Patent number: 12594349
    Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin/kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.
    Type: Grant
    Filed: November 21, 2023
    Date of Patent: April 7, 2026
    Assignee: Scribe Therapeutics Inc.
    Inventors: Jason Fernandes, Sean Higgins, Sarah Denny, Ross White, Emeric Jean Marius Charles, Addison Wright, Benjamin Demaree, Benjamin Oakes
  • Compositions and methods for the targeting of PCSK9
    Patent number: 12551573
    Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin/kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.
    Type: Grant
    Filed: November 21, 2023
    Date of Patent: February 17, 2026
    Assignee: Scribe Therapeutics Inc.
    Inventors: Jason Fernandes, Sean Higgins, Sarah Denny, Ross White, Emeric Jean Marius Charles, Addison Wright, Benjamin Demaree, Benjamin Oakes
  • NUCLEAR DNA-ANTIBODY SEQUENCING FOR JOINT PROFILING OF GENOTYPE AND PROTEIN IN SINGLE NUCLEI
    Publication number: 20240401124
    Abstract: The present disclosure provides materials and methods for contemporaneously analyzing genotype and phenotype from frozen specimens, the present disclosure can be extended to any biologic context where obtaining nucleic acid and protein information from single nuclei is valuable. As used herein, the method is termed nuclear DAb-seq (nDAb-seq).
    Type: Application
    Filed: October 18, 2022
    Publication date: December 5, 2024
    Inventors: Adam Abate, Harish Vasudevan, Benjamin Demaree, Cyrille L. Delley
  • PARTITIONING CELLS FOR HIGH THROUGHPUT SINGLE-CELL SEQUENCING
    Publication number: 20240254549
    Abstract: The present disclosure provides materials and methods for partitioning cells and high throughput, single-cell multi-omic sequencing. Methods for pathogen detection and identification, microbiome analysis, personalized medicine, environmental analysis where single-cell information is critical are each provided herein.
    Type: Application
    Filed: May 26, 2022
    Publication date: August 1, 2024
    Inventors: Adam Abate, Xiangpeng Li, Benjamin Demaree
  • COMPOSITIONS AND METHODS FOR THE TARGETING OF PCSK9
    Publication number: 20240123089
    Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.
    Type: Application
    Filed: November 21, 2023
    Publication date: April 18, 2024
    Inventors: Jason FERNANDES, Sean HIGGINS, Sarah DENNY, Ross WHITE, Emeric Jean Marius CHARLES, Addison WRIGHT, Benjamin DEMAREE, Manuel MOHR, Wenyuan ZHOU, Benjamin OAKES
  • COMPOSITIONS AND METHODS FOR THE TARGETING OF PCSK9
    Publication number: 20240124537
    Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin/kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.
    Type: Application
    Filed: November 21, 2023
    Publication date: April 18, 2024
    Inventors: Jason FERNANDES, Sean HIGGINS, Sarah DENNY, Ross WHITE, Emeric Jean Marius CHARLES, Addison WRIGHT, Benjamin DEMAREE, Manuel MOHR, Wenyuan ZHOU, Benjamin OAKES
  • Single Cell Genomic Sequencing Using Hydrogel Based Droplets
    Publication number: 20220033893
    Abstract: The present disclosure provides ultrahigh-throughput single cell genomic sequencing methods, referred to herein as “SiC-seq”, which methods include encapsulating single cells in molten gel droplets to facilitate bulk cell lysis and purification of genomic DNA in microgels. Systems and devices for practicing the subject methods are also provided.
    Type: Application
    Filed: December 21, 2017
    Publication date: February 3, 2022
    Inventors: Freeman Lan, Benjamin Demaree, Iain Clark, Adam R. Abate
  • Single cell genomic sequencing using hydrogel based droplets
    Patent number: 11124830
    Abstract: The present disclosure provides ultrahigh-throughput single cell genomic sequencing methods, referred to herein as “SiC-seq”, which methods include encapsulating single cells in molten gel droplets to facilitate bulk cell lysis and purification of genomic DNA in microgels. Systems and devices for practicing the subject methods are also provided.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: September 21, 2021
    Assignee: The Regents of the University of California
    Inventors: Freeman Lan, Benjamin Demaree, Iain Clark, Adam R. Abate
  • Single Cell Genomic Sequencing Using Hydrogel Based Droplets
    Publication number: 20200277672
    Abstract: The present disclosure provides ultrahigh-throughput single cell genomic sequencing methods, referred to herein as “SiC-seq”, which methods include encapsulating single cells in molten gel droplets to facilitate bulk cell lysis and purification of genomic DNA in microgels. Systems and devices for practicing the subject methods are also provided.
    Type: Application
    Filed: April 15, 2020
    Publication date: September 3, 2020
    Inventors: Freeman Lan, Benjamin Demaree, Iain Clark, Adam R. Abate