Patents by Inventor Benjamin Demaree

Benjamin Demaree has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOSITIONS AND METHODS FOR THE TARGETING OF PCSK9
    Publication number: 20240123089
    Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.
    Type: Application
    Filed: November 21, 2023
    Publication date: April 18, 2024
    Inventors: Jason FERNANDES, Sean HIGGINS, Sarah DENNY, Ross WHITE, Emeric Jean Marius CHARLES, Addison WRIGHT, Benjamin DEMAREE, Manuel MOHR, Wenyuan ZHOU, Benjamin OAKES
  • COMPOSITIONS AND METHODS FOR THE TARGETING OF PCSK9
    Publication number: 20240124537
    Abstract: Provided herein are gene repressor systems comprising fusion proteins, such as fusion proteins comprising a DNA binding domain such as a TALE, zinc finger or catalytically-dead CRISPR protein and guide nucleic acid (gRNA), which are useful in the repression of a proprotein convertase subtilisin/kexin Type 9 (PCSK9) gene. Also provided are methods of using such systems to repress transcription of PCSK9.
    Type: Application
    Filed: November 21, 2023
    Publication date: April 18, 2024
    Inventors: Jason FERNANDES, Sean HIGGINS, Sarah DENNY, Ross WHITE, Emeric Jean Marius CHARLES, Addison WRIGHT, Benjamin DEMAREE, Manuel MOHR, Wenyuan ZHOU, Benjamin OAKES
  • Single Cell Genomic Sequencing Using Hydrogel Based Droplets
    Publication number: 20220033893
    Abstract: The present disclosure provides ultrahigh-throughput single cell genomic sequencing methods, referred to herein as “SiC-seq”, which methods include encapsulating single cells in molten gel droplets to facilitate bulk cell lysis and purification of genomic DNA in microgels. Systems and devices for practicing the subject methods are also provided.
    Type: Application
    Filed: December 21, 2017
    Publication date: February 3, 2022
    Inventors: Freeman Lan, Benjamin Demaree, Iain Clark, Adam R. Abate
  • Single cell genomic sequencing using hydrogel based droplets
    Patent number: 11124830
    Abstract: The present disclosure provides ultrahigh-throughput single cell genomic sequencing methods, referred to herein as “SiC-seq”, which methods include encapsulating single cells in molten gel droplets to facilitate bulk cell lysis and purification of genomic DNA in microgels. Systems and devices for practicing the subject methods are also provided.
    Type: Grant
    Filed: April 15, 2020
    Date of Patent: September 21, 2021
    Assignee: The Regents of the University of California
    Inventors: Freeman Lan, Benjamin Demaree, Iain Clark, Adam R. Abate
  • Single Cell Genomic Sequencing Using Hydrogel Based Droplets
    Publication number: 20200277672
    Abstract: The present disclosure provides ultrahigh-throughput single cell genomic sequencing methods, referred to herein as “SiC-seq”, which methods include encapsulating single cells in molten gel droplets to facilitate bulk cell lysis and purification of genomic DNA in microgels. Systems and devices for practicing the subject methods are also provided.
    Type: Application
    Filed: April 15, 2020
    Publication date: September 3, 2020
    Inventors: Freeman Lan, Benjamin Demaree, Iain Clark, Adam R. Abate