Abstract: The subject matter disclosed herein is generally directed to stratifying and treating inflammatory diseases. In particular, the present invention provides for detecting treatment naive cell states that predict the response of a subject having inflammatory bowel disease to anti-TNF-blockade. The cells are T cells, NK cells, innate lymphoid cells, myeloid and/or epithelial cell subsets defined by their gene expression as determined by single cell RNA sequencing. Alternatively, the responders are identified by gene expression in a sample.

Abstract: The invention relates to methods of treating patients (either adult or paediatric) with tumours using G rich oligonucleotides. In embodiments of the invention, methods of treating patients with tumours using a combination of G rich oligonucleotides and a chemotherapeutic agent are provided. There are also provided pharmaceutical compositions and kits for use in the methods of the invention.

Abstract: There is provided by the invention a modified antibody molecule which selectively binds to a specific target, the antibody molecule being modified at, at least one amino acid residue that forms part of a glycosylation site in the variable region of an unmodified parent antibody molecule, characterised in that the modified antibody is not glycosylated at the previous glycosylation site of which the amino acid modification forms part and the modified antibody exhibits a greater binding affinity for the specific target than the unmodified parent antibody molecule. There is also provided nucleotide sequences, amino acid sequences and expression vectors encoding the modified antibodies, and uses thereof.