Patents by Inventor Benjamin E. Deverman

Benjamin E. Deverman has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Selective recovery
    Patent number: 11932668
    Abstract: Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
    Type: Grant
    Filed: August 13, 2021
    Date of Patent: March 19, 2024
    Assignee: California Institute of Technology
    Inventors: Benjamin E. Deverman, Paul H. Patterson, Viviana Gradinaru
  • TARGETING PEPTIDES FOR DIRECTING ADENO-ASSOCIATED VIRUSES (AAVs)
    Publication number: 20230295659
    Abstract: Disclosed herein are peptide sequences capable of directing adeno-associated viruses (AAV) to target specific environments, for example the nervous system and the heart, in a subject. Also disclosed are AAVs having non-naturally occurring capsid proteins comprising the disclosed peptide sequences, and methods of using the AAVs to treat diseases.
    Type: Application
    Filed: October 17, 2022
    Publication date: September 21, 2023
    Inventors: Benjamin E. Deverman, Viviana Gradinaru, Ken Y. Chan
  • Targeting peptides for directing adeno-associated viruses (AAVs)
    Patent number: 11499165
    Abstract: Disclosed herein are peptide sequences capable of directing adeno-associated viruses (AAV) to target specific environments, for example the nervous system and the heart, in a subject. Also disclosed are AAVs having non-naturally occurring capsid proteins comprising the disclosed peptide sequences, and methods of using the AAVs to treat diseases.
    Type: Grant
    Filed: December 9, 2016
    Date of Patent: November 15, 2022
    Assignee: California Institute of Technology
    Inventors: Benjamin E. Deverman, Viviana Gradinaru, Ken Y. Chan
  • AAV VARIANTS WITH ENHANCED TROPISM
    Publication number: 20220281922
    Abstract: The disclosure relates to compositions, methods, and processes for the preparation, use, and/or formulation of adeno-associated virus capsid proteins, wherein the capsid proteins comprise targeting peptide inserts for enhanced tropism to a target tissue.
    Type: Application
    Filed: July 31, 2020
    Publication date: September 8, 2022
    Inventors: Dinah Wen-Yee SAH, Jinzhao HOU, Kei ADACHI, Wei WANG, Qingmin CHEN, Jenna CARROLL SOPER, Amy REN, Xiao-Qin REN, Benjamin E. DEVERMAN, Viviana GRADINARU, Qin HUANG, Sripriya RAVINDRA KUMAR
  • SYSTEMS FOR EVOLVED ADENO-ASSOCIATED VIRUSES (AAVS) FOR TARGETED DELIVERY
    Publication number: 20220143214
    Abstract: Methods for screening for an adeno-associated virus (AAV) capsid protein that can bind to a target protein (e.g., Ly6 protein) and related compositions are provided in aspects of the disclosure.
    Type: Application
    Filed: January 30, 2020
    Publication date: May 12, 2022
    Applicant: The Broad Institute, Inc.
    Inventors: Benjamin E. Deverman, Qin Huang, Ken Y. Chan
  • SELECTIVE RECOVERY
    Publication number: 20220098243
    Abstract: Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
    Type: Application
    Filed: August 13, 2021
    Publication date: March 31, 2022
    Inventors: Benjamin E. Deverman, Paul H. Patterson, Viviana Gradinaru
  • MACHINE LEARNING ACCELERATED PROTEIN ENGINEERING THROUGH FITNESS PREDICTION
    Publication number: 20210403946
    Abstract: Techniques for identifying production-fit amino acid sequence libraries are disclosed. The techniques may include accessing a statistical model relating an input amino acid sequence to production fitness of a protein having the input amino acid sequence, obtaining production fitness information for production-fit variant amino acid sequences, and generating an amino acid sequence library having amino acid sequences with predicted production fitness in accordance with the production fitness information. The techniques further include using a statistical model for a protein characteristic other than production fitness to generate an amino acid sequence library having amino acid sequences that are both predicted to be production-fit and have the protein characteristic.
    Type: Application
    Filed: April 29, 2021
    Publication date: December 30, 2021
    Applicant: The Broad Institute, Inc.
    Inventors: Benjamin E. Deverman, FatmaElzahraa Eid, Ken Y. Chan
  • Selective recovery
    Patent number: 11117933
    Abstract: Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
    Type: Grant
    Filed: November 11, 2019
    Date of Patent: September 14, 2021
    Assignee: California Institute of Technology
    Inventors: Benjamin E. Deverman, Paul H. Patterson, Viviana Gradinaru
  • AAV VARIANTS WITH ENHANCED TROPISM
    Publication number: 20210277418
    Abstract: The disclosure relates to compositions, methods, and processes for the preparation, use, and/or formulation of adeno-associated virus capsid proteins, wherein the capsid proteins comprise targeting peptide inserts for enhanced tropism to a target tissue.
    Type: Application
    Filed: August 2, 2019
    Publication date: September 9, 2021
    Inventors: Dinah Wen-Yee Sah, Jinzhao Hou, Kei Adachi, Wei Wang, Qingmin Chen, Jenna Carroll Soper, Amy Ren, Xiao-Qin Ren, Benjamin E. Deverman, Viviana Gradinaru, Qin Huang
  • Selective recovery
    Patent number: 10934329
    Abstract: Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
    Type: Grant
    Filed: April 9, 2019
    Date of Patent: March 2, 2021
    Assignee: California Institute of Technology
    Inventors: Benjamin E. Deverman, Paul H. Patterson, Viviana Gradinaru
  • SELECTIVE RECOVERY
    Publication number: 20200087353
    Abstract: Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
    Type: Application
    Filed: November 11, 2019
    Publication date: March 19, 2020
    Inventors: Benjamin E. Deverman, Paul H. Patterson, Viviana Gradinaru
  • Selective recovery
    Patent number: 10519198
    Abstract: Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
    Type: Grant
    Filed: December 17, 2018
    Date of Patent: December 31, 2019
    Assignee: California Institute of Technology
    Inventors: Benjamin E. Deverman, Paul H. Patterson, Viviana Gradinaru
  • SELECTIVE RECOVERY
    Publication number: 20190292230
    Abstract: Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
    Type: Application
    Filed: April 9, 2019
    Publication date: September 26, 2019
    Inventors: Benjamin E. Deverman, Paul H. Patterson, Viviana Gradinaru
  • Selective recovery
    Patent number: 10301360
    Abstract: Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: May 28, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Benjamin E. Deverman, Paul H. Patterson, Viviana Gradinaru
  • SELECTIVE RECOVERY
    Publication number: 20190144509
    Abstract: Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
    Type: Application
    Filed: December 17, 2018
    Publication date: May 16, 2019
    Inventors: Benjamin E. Deverman, Paul H. Patterson, Viviana Gradinaru
  • Selective recovery
    Patent number: 10202425
    Abstract: Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
    Type: Grant
    Filed: March 20, 2018
    Date of Patent: February 12, 2019
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Benjamin E. Deverman, Paul H. Patterson, Viviana Gradinaru
  • SELECTIVE RECOVERY
    Publication number: 20180230186
    Abstract: Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
    Type: Application
    Filed: March 20, 2018
    Publication date: August 16, 2018
    Inventors: Benjamin E. Deverman, Paul H. Patterson, Viviana Gradinaru
  • Selective recovery
    Patent number: 9957303
    Abstract: Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
    Type: Grant
    Filed: February 1, 2017
    Date of Patent: May 1, 2018
    Assignee: CALIFORNIA INSTITUTE OF TECHNOLOGY
    Inventors: Benjamin E. Deverman, Paul H. Patterson, Viviana Gradinaru
  • SELECTIVE RECOVERY
    Publication number: 20170240885
    Abstract: Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
    Type: Application
    Filed: February 1, 2017
    Publication date: August 24, 2017
    Inventors: Benjamin E. Deverman, Paul H. Patterson, Viviana Gradinaru
  • SELECTIVE RECOVERY
    Publication number: 20170204144
    Abstract: Provided herein are methods of selective screening. In addition, various targeting proteins and sequences, as well as methods of their use, are also provided.
    Type: Application
    Filed: February 1, 2017
    Publication date: July 20, 2017
    Inventors: Benjamin E. Deverman, Paul H. Patterson, Viviana Gradinaru