Abstract: Systems and techniques that facilitate TLS-based optimization of Stark tone tuning are provided. In various embodiments, a system can comprise a receiver component that can access a qubit topology. In various aspects, the system can further comprise an optimization component that can identify, based on a set of two-level-system, (TLS) frequency regions of the qubit topology, one or more Stark tone frequencies. In various instances, the system can further comprise an execution component that can apply, to a qubit lattice corresponding to the qubit topology, one or more Stark tones that have the one or more Stark tone frequencies, thereby eliminating frequency collisions in the qubit lattice.