Abstract: A device for filling pressurized gas tanks, including a fluid transfer circuit having an upstream end connected to a plurality of sources of pressurized fluid and a downstream end having at least one dispenser intended to be connected to a tank to be filled, the sources being connected in parallel, each source has a fluid outlet connected to a respective outlet valve, the transfer lines being connected in parallel to the at least one dispenser and each having a respective transfer valve, the transfer lines and the transfer valves being dimensioned so as to transfer a maximum transfer gas flow which is smaller than the maximum filling gas flow, the sum of a plurality of maximum transfer gas flows provided by a plurality of outlet valves and a plurality of transfer lines being greater than or equal to the maximum filling gas flow.

Abstract: The invention relates to a method for producing three-dimensional, preferably porous, hydrogel structures by a layer build-up technique, wherein the method includes the following steps. Providing (S1) of a liquid hydrogel solution, preferably a liquid alginate solution, and a, preferably transportable, sample carrier. Layerwise applying (S2) the liquid hydrogel solution onto the sample carrier in a temperature environment, the temperature of which is below the freezing point of the hydrogel solution, to produce a frozen 3D layered hydrogel structure. In order to increase advantageously the porosity of the 3D layered hydrogel structure, i.e. the proportion of small voids, cavities and/or depressions in the 3D layered hydrogel structure, the method further includes the step of drying (S3) of the frozen 3D layered hydrogel structure, e.g. by freeze-drying, to produce a porous 3D hydrogel structure. The invention further relates to a device for the layerwise building-up of three-dimensional hydrogel structures.

Abstract: Multispecific binding proteins that bind NKG2D receptor, CD16, and B cell-activating factor receptor (BAFF-R) are described, as well as pharmaceutical compositions and therapeutic methods of the multispecific binding proteins useful for the treatment of cancer and autoimmune inflammatory diseases.

Abstract: The invention relates to a method for producing three-dimensional, preferably porous, hydrogel structures by means of layer build-up technique, wherein the method comprises the following steps. Providing (S1) of a liquid hydrogel solution, preferably a liquid alginate solution, and a, preferably transportable, sample carrier. Layerwise applying (S2) the liquid hydrogel solution onto the sample carrier in a temperature environment, the temperature of which is below the freezing point of the hydrogel solution, to produce a frozen 3D layered hydrogel structure. In order to increase advantageously the porosity of the 3D layered hydrogel structure, i.e. the proportion of small voids, cavities and/or depressions in the 3D layered hydrogel structure, the method according to the invention further comprises the step of drying (S3) of the frozen 3D layered hydrogel structure, e.g. by means of freeze-drying, to produce a porous 3D hydrogel structure.

Abstract: Multispecific binding proteins that bind NKG2D receptor, CD16, and B cell-activating factor receptor (BAFF-R) are described, as well as pharmaceutical compositions and therapeutic methods of the multispecific binding proteins useful for the treatment of cancer and autoimmune inflammatory diseases.

Abstract: Disclosed are proteins with antibody heavy chain and light chain variable domains that can be paired to form an antigen-binding site targeting BAFF-R on a cell, pharmaceutical compositions comprising such proteins, and therapeutic methods using such proteins and pharmaceutical compositions, including for the treatment of cancer or autoimmune disease.

Abstract: The invention relates to a method for producing vascularized biological tissue, having the steps of producing a network structure made of a plurality of interconnected filaments (11) of a support polymer, coating the network structure with a protein material, populating the coated network structure with endothelial cells (2, 2A) and tissue-forming biological cells (3), and dissolving the filaments (11) such that the vascularized tissue (1) is formed. The vascularized tissue (1) comprises cardiomyocytes, liver cells, renal cells, nerve cells, and/or pancreatic cells, for example.

Abstract: Transporting loads is a fundamental component of intralogistics. Autonomous industrial trucks can be used for this. The autonomous industrial truck claimed according to the invention is able, by means of the implemented navigation, load receiving and load placing methods, to ensure efficient transporting of loads. The invention relates to an autonomous industrial truck having a rearwardly-directed sensor unit for detecting the load and the loading environment and implemented process sequences for approaching the load, receiving the load and placing the load.

Abstract: Computer-based process modeling and simulation methods and systems combine first principles models and machine learning models to benefit where either model is lacking. In one example, input values (measurements) are adjusted by first principles techniques. A machine learning model of the chemical process of interest is trained on the adjusted values. In another example, a machine learning model represents the residual (delta) between a first principles model prediction and empirical data. Residual machine learning models correct physical phenomena predictions in a first principles model of the chemical process. In another example, a first principles simulation model uses the process input data and predictions of the machine learning model to generate simulated results of the chemical process.

Abstract: Device for filling pressurized gas tanks, in particular hydrogen tanks of vehicles, comprising a fluid transfer circuit having an upstream end connected to a plurality of sources (2 to 10) of pressurized fluid and a downstream end comprising at least one dispenser intended to be connected to a tank to be filled, the sources (2 to 10) being connected in parallel to the at least one dispenser, each source (2 to 10) comprising a fluid outlet connected to a respective outlet valve (22 to 30), the sources (2 to 10) being connected in parallel in different subgroups to respective transfer lines (35 to 37), i.e.

Abstract: Device for supplying pressurized fluid, including a first valve accommodating an internal fluid circuit, the device having a second valve having an internal circuit, the second valve forming a separate physical entity from the first valve, the first valve and the second valve having respective coupling members that form a male/female quick-connection system for removably connecting the second valve to the first valve, the internal circuits including a set of control valves for allowing or preventing the flow of the fluid towards an outlet of the device when the second valve is coupled to the first valve via the quick-connection system.

Abstract: Device for supplying pressurized fluid, including a first valve housing an internal fluid circuit, the device including a second valve having an internal circuit and forming a physical entity distinct from the first valve. The first and the second valve including respective coupling members forming a detachable male/female quick-connection system for the second valve on the first valve. The two valves being configured such as to place their internal circuits in communication when the second valve is coupled to the first valve via the quick-connection system.

Abstract: The invention relates to a treatment device (100) which is designed for extracorporeal blood treatment of blood of a subject (2) for an immunotolerance enhancement of the subject (2), comprising at least one container (10) which has an interior (11) for receiving a blood sample (1) of blood of the subject (2) and an exchange device (20) designed to supply and/or discharge the blood sample (1) into or out of the interior (11) of the container (10) and comprising a cell exposure device (30) which is positioned in the container (10) and has biological cell material (31) with surface molecules, said cell material being arranged in the interior (11) of the container (10) for a material interaction with the blood sample (1), including a reaction of endogenous immune cells in the blood with the surface molecules of the cell material. The invention also relates to a kit for extracorporeal blood treatment and to a method for operating the treatment device.

Abstract: The invention relates to a method for producing three-dimensional, preferably porous, hydrogel structures by means of layer build-up technique, wherein the method comprises the following steps. Providing (S1) of a liquid hydrogel solution, preferably a liquid alginate solution, and a, preferably transportable, sample carrier. Layerwise applying (S2) the liquid hydrogel solution onto the sample carrier in a temperature environment, the temperature of which is below the freezing point of the hydrogel solution, to produce a frozen 3D layered hydrogel structure. In order to increase advantageously the porosity of the 3D layered hydrogel structure, i.e. the proportion of small voids, cavities and/or depressions in the 3D layered hydrogel structure, the method according to the invention further comprises the step of drying (S3) of the frozen 3D layered hydrogel structure, e.g. by means of freeze-drying, to produce a porous 3D hydrogel structure.

Abstract: A valve for a pressurized fluid, including a body housing a fluid circuit including an upstream end configured to be placed in communication with a reserve of pressurized fluid and a downstream end configured to be placed in communication with a receiver apparatus, the circuit including a control member controlling the flow rate in the circuit, said flow rate control member being operated by a mobile actuating member configured to move relative to the body of the valve, the valve including at least a first functional electronic member and a second functional electronic member, the second functional electronic member being mounted removably on the body of the valve.

Abstract: System and methods that provide a new paradigm for solving process system engineering (PSE) problems using embedded artificial intelligence (AI) techniques. The approach can facilitate process model building and deployment and benefits from emerging AI and machine learning (ML) technology. The systems and methods can define PSE problems with mathematical equations, first principles and domain knowledges, and physical and economical constraints. The systems and methods generate a dataset of recorded measurements for variables of the process, and reduce the dataset by cleansing bad quality data segments and measurements for uninformative process variables from the dataset. The dataset is then enriched by, for example, applying nonlinear transforms, engineering calculations, and statistical measurements.

Abstract: A device for supplying pressurized fluid, including a first valve accommodating an internal fluid circuit, the device including a second valve including an internal circuit, the second valve forming a separate physical entity from the first valve, the first valve and the second valve including respective coupling members that form a male/female quick-connection system for removably connecting the second valve to the first valve, the internal circuits including a set of valves configured to allow or prevent the flow of the fluid towards an outlet of the device when the second valve is coupled to the first valve via the quick-connection system.

Abstract: Computer-based process modeling and simulation methods and systems combine first principles models and machine learning models to benefit where either model is lacking. In one example, input values (measurements) are adjusted by first principles techniques. A machine learning model of the chemical process of interest is trained on the adjusted values. In another example, a machine learning model represents the residual (delta) between a first principles model prediction and empirical data. Residual machine learning models correct physical phenomena predictions in a first principles model of the chemical process. In another example, a first principles simulation model uses the process input data and predictions of the machine learning model to generate simulated results of the chemical process.

Abstract: A configuration for installation into a pipeline of a fluid network. The configuration has a connection housing with an inlet, an outlet, and a connection opening for connection of an exchangeable functional unit. The connection housing has a rotatably arranged core piece whose rotation makes it possible for the throughflow of the fluid through the connection housing to be blocked and/or released. The core piece has a receptacle for connection of the functional unit, and the receptacle and the connection opening are oriented in the same direction.

Abstract: Third-party publishers (such as websites) provide online advertisements combined with social endorsement information to users. A request for an advertisement is received from a viewing user via a third-party publisher system. A particular advertisement is selected in response to this request, and one or more advertisement tags associated with the advertisement are retrieved. The advertisement tags comprise information related to the advertisement. Social networking system data for users related to the viewing user is retrieved. Social endorsement information is obtained using the social networking system data and the advertisement tags associated with the advertisement. The social endorsement information and the advertisement are then combined and transmitted to the third-party publisher system, or are transmitted individually for combination by the third-party publisher system.