Abstract: Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with p110 activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymphobl

Abstract: A suture retention device includes a stack of suture engaging members which can be provided by coils or other segments of a spring. A suture engages with the stack so as to permit travel of the retention device along the suture in one direction more facilely than travel along the suture in the other direction. The retention device can include a housing that encloses the spring or other stack structure, and the suture can pass from a first hole in the housing, through the suture engaging members, and to a second hole in the housing. A suture anchor can be attached to the suture, and the resulting assembly can be combined with a needle designed to introduce the anchor and suture into patient tissue, e.g. in the conduct of a gastropexy procedure.

Abstract: Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity, The present invention also enables methods for treating cancers that are mediated, dependent on or associated with pi 110? activity, including but not restricted to leukemias, such as Acute Myeloid leukaemia (AML) Myelo-dysplastic syndrome (MDS) myelo-proliferative diseases (MPD) Chronic Myeloid Leukemia (CML) T-cell Acute Lymp

Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are gem-disubstituted or spirocyclic pyridine, pyrimidine and triazine derivatives.

Abstract: The present invention provides MDM2 inhibitor compounds of Formula I, wherein the variables are defined above, which compounds are useful as therapeutic agents, particularly for the treatment of cancers. The present invention also relates to pharmaceutical compositions that contain an MDM2 inhibitor.

Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-mediated disorders, such as cancer. The subject compounds are fused pyridine, pyrimide and triazine derivatives.

Abstract: Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of CDK4-me-dialed disorders, such as cancer. The subject compounds arc gem-disubstituted or spimcyclic pyridine, pyrimidine and triazine derivatives.

Abstract: Selected compounds are effective for prophylaxis and treatment of inflammation and inflammatory disorders, such as NIK-mediated disorders. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, inflammation and the like.

Abstract: Substituted bicyclic heteroaryls and compositions containing them, for the treatment of general inflammation, arthritis, rheumatic diseases, osteoarthritis, inflammatory bowel disorders, inflammatory eye disorders, inflammatory or unstable bladder disorders, psoriasis, skin complaints with inflammatory components, chronic inflammatory conditions, including but not restricted to autoimmune diseases such as systemic lupus erythematosis (SLE), myestenia gravis, rheumatoid arthritis, acute disseminated encephalomyelitis, idiopathic thrombocytopenic purpura, multiples sclerosis, Sjoegren's syndrome and autoimmune hemolytic anemia, allergic conditions including all forms of hypersensitivity.

Abstract: A process is disclosed for discriminating between received ranging signals, such as GPS, GNSS, and radar signals, which arrive via a single path and those which arrive via multiple paths. The number of paths is also estimated. This is accomplished by comparing the residual for an ith order ML estimator of signal time of arrival, where order refers to the number of signal paths for which the estimator is optimal, to a discriminant determined either analytically or empirically and deciding that i distinct signal path components are present in the observation of the signal if for all kth order estimators where k<i, the residual is greater than the discriminant for that order estimator and the residual of the ith order estimator is not greater than the discriminant for that order estimator. The invention is particularly useful in obtaining an appropriate signal model for model-based estimation methods.

Abstract: A method of forming a cross-correlation function R ? ( ? ) = ? N 2 k = N 1 ? r ? ( k ) ? m ? ( k - ? ) , mathematically as an inner product of the samples of a received signal r(t) and a replica of the signal modulation function m(t), with a computational burden reduced by many orders of magnitude in pseudonoise (PN) coded ranging applications is accomplished by a two step process. First, a single weighted sum of the signal samples forms a small dimension vector, of the order of tens of elements. Second, the inner product of this vector and vectors of the same dimension of samples of the signal modulation generating function, delayed by arbitrarily many values of the delay parameter ?, result in fine delay resolution correlation function values. The process comparatively entails a relatively small computational burden, does not compromise fidelity, and makes real-time optimal range estimation practical.

Abstract: In signal transmission ranging systems such as GPS, radar, and the like, accuracy of the ranging information most generally is effected by the presence of multiple paths of signal transmission, i.e., multipath. Optimal methods for estimating signal delay are signal model dependent. Signal models are most ambiguous with secondary path signals near the delay of the direct path signal. This invention provides a means of discriminating between received signals in which no secondary path signals are present in the signal observations and where one or more secondary path signals are present in those observations, and the number of such secondary path signals. Means described in the invention to accomplish this discrimination are based on Maximum Likelihood (ML) signal parameter estimation processes; processes which are model dependent. The invention provides the mechanism to identify the model appropriate to the observed signal.

Abstract: A method for mitigating multipath effects in radio systems which is based on searching for and finding a maximum likelihood estimate of range for a received signal is provided. In determining the maximum likelihood estimate, the correlation process uses a high resolution step method in processing the received signal sample values to develop an estimation statistic. The estimation statistic using the correlations of the received signal is based on a new derived representative set of coefficients formed from a nonlinear combination of parameters of the received signal transformed into a linearly solvable invertible parameter set allowing solution of the maximization process of the estimation statistic over a reduced dimension search space. Additionally there is a method of constraining the relative amplitude of received secondary signals to obtain a refinement of the optimal solution of range.

Abstract: This invention involves a method for mitigating multipath effects in radio ranging systems which is based on searching for and finding a maximum likelihood estimate of range for a received signal in a signal ranging system. In determining the maximum likelihood estimate, the correlation process uses a high resolution step method in processing the received signal sample values to develop an estimation statistic. The estimation statistic using the correlations of the received signal is based on a new derived representative set of coefficients formed from a nonlinear combination of parameters of the received signal transformed into an invertible linear combination which allows solution of the maximization process of the estimation statistic. Additionally there is a method of constraining the relative amplitude of received secondary signals to obtain a refinement of the optimal solution of range.