Patents by Inventor Benjamin G. Neel

Benjamin G. Neel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Hedgehog pathway inhibition for cartilage tumor and metachondromatosis treatment
    Patent number: 9833446
    Abstract: A method for preventing, slowing, or blocking the formation of an exostosis or an enchondromas comprising administering to an animal in need thereof a hedgehog pathway inhibitor such as a Smoothened inhibitor.
    Type: Grant
    Filed: March 14, 2013
    Date of Patent: December 5, 2017
    Assignees: Rhode Island Hospital, University Health Network
    Inventors: Wentian Yang, Benjamin G. Neel
  • Hedgehog Pathway Inhibition for Cartilage Tumor and Metachondromatosis Treatment
    Publication number: 20150045363
    Abstract: Hedgehog pathway inhibitors, such as small molecules, are used to prevent, slow, block the formation of cartilage tumors as well as exostosis or enchondromas.
    Type: Application
    Filed: March 14, 2013
    Publication date: February 12, 2015
    Inventors: Wentian Yang, Benjamin G. Neel
  • Diagnosis and Treatment of Noonan Syndrome and Neoplastic Disorders
    Publication number: 20100227778
    Abstract: Methods and compositions for diagnosing and treating Noonan syndrome and neoplastic disorders are provided herein.
    Type: Application
    Filed: August 17, 2007
    Publication date: September 9, 2010
    Applicants: The Brigham and Women's Hospital, Inc., Beth Israel Deaconess Medical Center, Inc.
    Inventors: Benjamin G. Neel, Amy E. Roberts, Raju Kucherlapati, Kenneth D. Swanson, Toshiyuki Araki
  • Gab2 (p97) gene and methods of use thereof
    Publication number: 20040086893
    Abstract: This invention relates to the purification, cloning and characterization of a novel gene, Gab2. In response to extracellular stimuli (e.g., cyokines, growth factors, hormones and antigens), Gab2 binds several signal relay molecules, including the protein-tyrosine phosphatase SHP-2 and phosphatidylinositol-3-OH kinase (PI-3K), which results in the initiation of multiple signaling cascades. Gab2 nucleic acid molecules, peptides, vectors, host cells, probes, antibodies, knockout and transgenic animals are provided. The invention also relates to methods of diagnosis, prevention and treatment of Gab2-mediated conditions such as allergic responses, neoplastic disorders and immune disorders.
    Type: Application
    Filed: April 25, 2003
    Publication date: May 6, 2004
    Applicant: Beth Israel Deaconess Medical Center, Inc.
    Inventors: Haihua Gu, Benjamin G. Neel, Jean-Pierre Kinet
  • Activated mutants of SH2-domain-containing protein tyrosine phosphatases and methods of use thereof
    Patent number: 6156551
    Abstract: The invention relates to novel mutant SH2 domain containing protein tyrosine phosphatases wherein the phosphatase is partially or constitutively active; and whose ability to regulate biological processes are different from the wildtype protein tyrosine phosphatases. The invention also relates to methods of use of the novel mutants, for example, in in vitro assays to screen for binding partners and inhibitors of protein tyrosine phosphatases and in the treatment of protein tyrosine phosphatase mediated diseases or conditions.
    Type: Grant
    Filed: June 5, 1998
    Date of Patent: December 5, 2000
    Assignees: Beth Israel Deaconess Medical Center, Joslin Diabetes Center
    Inventors: Benjamin G. Neel, Alana M. O'Reilly, Steven Shoelson, Scott Pluskey
  • Peptide which binds SH.sub.2 domains of protein tyrosine phosphatase SH-PTP1
    Patent number: 5659012
    Abstract: Novel assays for identifying agents which alter the effect of erythropoietin on proliferation of erythroid cells and agents identified thereby. Novel peptide comprising the erythropoietin receptor binding site for SH-PTP1.
    Type: Grant
    Filed: March 10, 1995
    Date of Patent: August 19, 1997
    Assignee: Whitehead Institute for Biomedical Research
    Inventors: Ursula Klingmuller, Stephen Michnick, Benjamin G. Neel, Ulrike Lorenz, Harvey F. Lodish
  • Methods for identifying a tyrosine phosphatase abnormality associated with neoplastic disease
    Patent number: 5536636
    Abstract: The present invention relates to the isolation of genes encoding novel protein tyrosine phosphatases (PTPs) having SH2 domains, the nucleic acid sequences isolated, and the encoded phosphatases. The invention further relates to methods of altering tyrosine phosphatase activities encoded by the novel phosphatases. By altering (i.e., increasing or decreasing) tyrosine phosphatase activity, one can alter megakaryocyte cell function, and thereby alter platelet production. Alteration of the genes is associated with neoplastic disease.
    Type: Grant
    Filed: February 28, 1994
    Date of Patent: July 16, 1996
    Assignees: Beth Israel Hospital, Massachusetts Institute of Technology
    Inventors: Robert M. Freeman, Jr., Jorge Plutzky, Benjamin G. Neel, Robert D. Rosenberg