Patents by Inventor Benjamin Gaston

Benjamin Gaston has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210145785
    Abstract: A method of stimulating ventilatory and/or respiratory drive in a subject in need thereof includes administering to the subject a therapeutically effective amount of a composition comprising a D-cysteine alkyl ester, adduct thereof, or pharmaceutically acceptable salt, tautomer, or solvate thereof.
    Type: Application
    Filed: January 5, 2021
    Publication date: May 20, 2021
    Inventors: Benjamin Gaston, Stephen Lewis
  • Patent number: 10881633
    Abstract: A method of stimulating ventilatory and/or respiratory drive in a subject in need thereof includes administering to the subject a therapeutically effective amount of a composition comprising a D-cysteine alkyl ester, adduct thereof, or pharmaceutically acceptable salt, tautomer, or solvate thereof.
    Type: Grant
    Filed: July 18, 2019
    Date of Patent: January 5, 2021
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Benjamin Gaston, Stephen Lewis
  • Patent number: 10543187
    Abstract: A method of stimulating ventilatory and/or respiratory drive in a subject in need thereof includes administering to the subject a therapeutically effective amount of a composition comprising a cystine ester or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: September 24, 2018
    Date of Patent: January 28, 2020
    Assignee: CASE WESTERN RESERVE UNIVERSITY
    Inventors: Benjamin Gaston, Stephen Lewis
  • Publication number: 20190358189
    Abstract: A method of stimulating ventilatory and/or respiratory drive in a subject in need thereof includes administering to the subject a therapeutically effective amount of a composition comprising a D-cysteine alkyl ester, adduct thereof, or pharmaceutically acceptable salt, tautomer, or solvate thereof.
    Type: Application
    Filed: July 18, 2019
    Publication date: November 28, 2019
    Inventors: Benjamin Gaston, Stephen Lewis
  • Publication number: 20190231732
    Abstract: A method of stimulating ventilatory and/or respiratory drive in a subject in need thereof includes administering to the subject a therapeutically effective amount of a composition comprising a cystine ester or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: September 24, 2018
    Publication date: August 1, 2019
    Inventors: Benjamin Gaston, Stephen Lewis
  • Patent number: 10080732
    Abstract: A method of stimulating ventilatory and/or respiratory drive in a subject in need thereof includes administering to the subject a therapeutically effective amount of a composition comprising a cystine ester or a pharmaceutically acceptable salt thereof. Embodiments described herein relate to compositions and methods of stimulating ventilatory and/or respiratory drive in a subject in need thereof, and particularly relates to compositions and methods of treating breathing diseases and/or disorders associated with impaired ventilatory and/or respiratory drive.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: September 25, 2018
    Assignee: Case Western Reserve University
    Inventors: Benjamin Gaston, Stephen Lewis
  • Publication number: 20180000769
    Abstract: A method of stimulating ventilatory and/or respiratory drive in a subject in need thereof includes administering to the subject a therapeutically effective amount of a composition comprising a cystine ester or a pharmaceutically acceptable salt thereof. Embodiments described herein relate to compositions and methods of stimulating ventilatory and/or respiratory drive in a subject in need thereof, and particularly relates to compositions and methods of treating breathing diseases and/or disorders associated with paired ventilatory and/or respiratory drive.
    Type: Application
    Filed: January 13, 2016
    Publication date: January 4, 2018
    Inventors: Benjamin Gaston, Stephen Lewis
  • Patent number: 7419834
    Abstract: The present invention describes a novel, simplified method for detecting and monitoring whether the presence of nitrosylated proteins, such as S-nitrosoproteins, in a biological sample using fluorescence detection. The present invention further describes a method which can both quantify and identify the nature of nitrosylated proteins, which method is useful for monitoring both normal and disease states, in the development and screening of potential therapeutic drug species.
    Type: Grant
    Filed: December 12, 2002
    Date of Patent: September 2, 2008
    Assignees: University of Massachusetts, University of Virginia Patent Foundation
    Inventors: Joan Mannick, Benjamin Gaston, Barbara Leinweber
  • Publication number: 20080199967
    Abstract: The present invention describes a novel, simplified method for detecting and monitoring the presence of nitrosylated proteins, such as S-nitrosoproteins, in a biological sample using fluorescence detection. The present invention further describes a method which can both quantify and identify the nature of nitrosylated proteins, which method is useful for monitoring both normal and disease states, in the development and screening of potential therapeutic drug species.
    Type: Application
    Filed: January 17, 2008
    Publication date: August 21, 2008
    Applicants: UNIVERSITY OF MASSACHUSETTS MEDICAL CENTER, UNIVERSITY OF VIRGINIA PATENT FOUNDATION
    Inventors: Joan Mannick, Benjamin Gaston, Barbara Leinweber
  • Publication number: 20070202605
    Abstract: The invention provides a method of detecting an S-nitrosothiol in a sample which includes treating the sample with a transition metal such as copper (I) and cysteine in the presence of a substance capable of blocking interactions between iron-containing compounds and NO and detecting the generated NO.
    Type: Application
    Filed: June 16, 2005
    Publication date: August 30, 2007
    Inventors: Allan Doctor, Benjamin Gaston
  • Publication number: 20070185205
    Abstract: The present invention relates to a method of treating asthma by raising the pH of the airways of an individual. The effect can be mediated directly by administering a pharmaceutically acceptable basic solution or alternatively, the effect can be mediated by enhancing the activity of glutaminase.
    Type: Application
    Filed: April 16, 2007
    Publication date: August 9, 2007
    Inventors: John Hunt, Benjamin Gaston
  • Publication number: 20070134166
    Abstract: The present invention relates to a method of treating asthma by raising the pH of the airways of an individual. The effect can be mediated directly by administering a pharmaceutically acceptable basic solution or alternatively, the effect can be mediated by enhancing the activity of glutaminase.
    Type: Application
    Filed: January 15, 2007
    Publication date: June 14, 2007
    Inventors: John Hunt, Benjamin Gaston
  • Publication number: 20070128126
    Abstract: The present invention relates to a method of treating asthma by raising the pH of the airways of an individual. The effect can be mediated directly by administering a pharmaceutically acceptable basic solution or alternatively, the effect can be mediated by enhancing the activity of glutaminase.
    Type: Application
    Filed: January 23, 2007
    Publication date: June 7, 2007
    Inventors: John Hunt, Benjamin Gaston
  • Publication number: 20050222103
    Abstract: The present invention relates to a method of treating asthma by raising the pH of the airways of an individual. The effect can be mediated directly by administering a pharmaceutically acceptable basic solution or alternatively, the effect can be mediated by enhancing the activity of glutaminase.
    Type: Application
    Filed: May 20, 2005
    Publication date: October 6, 2005
    Inventors: John Hunt, Benjamin Gaston
  • Publication number: 20050131064
    Abstract: The present invention is directed to the treatment of cystic fibrosis that involves administration of a nitrosylating agent, such as S-nitrosoglutathione or ethyl nitrite.
    Type: Application
    Filed: February 6, 2004
    Publication date: June 16, 2005
    Inventors: Benjamin Gaston, Jonathan Stamler
  • Publication number: 20040203068
    Abstract: The present invention describes a novel, simplified method for detecting and monitoring whether the presence of nitrosylated proteins, such as S-nitrosoproteins, in a biological sample using fluorescence detection. The present invention further describes a method which can both quantify and identify the nature of nitrosylated proteins, which method is useful for monitoring both normal and disease states, in the development and screening of potential therapeutic drug species.
    Type: Application
    Filed: December 12, 2002
    Publication date: October 14, 2004
    Inventors: Joan Mannick, Benjamin Gaston, Barbara Leinweber
  • Patent number: 6723703
    Abstract: The present invention is directed to the treatment of cystic fibrosis that involves the administration of a nitrosylating agent, such as S-nitrosoglutathione or ethyl nitrite.
    Type: Grant
    Filed: March 24, 2003
    Date of Patent: April 20, 2004
    Assignees: Duke University, University of Virginia Patent Foundation
    Inventors: Benjamin Gaston, Jonathan S. Stamler
  • Publication number: 20030212004
    Abstract: Composition comprising nitrosylating agent is administered to a patient having cystic fibrosis.
    Type: Application
    Filed: March 24, 2003
    Publication date: November 13, 2003
    Inventors: Benjamin Gaston, Jonathan S. Stamler
  • Publication number: 20030170316
    Abstract: Asthma is ameliorated, and mild or moderate asthma is prevented from progressing to more severe asthma by administering agents which prevent and/or accommodate for S-nitrosothiol breakdown. The method reduces requirements for systemic corticosteroids for the treatment of severe asthma.
    Type: Application
    Filed: April 1, 2003
    Publication date: September 11, 2003
    Inventors: Benjamin Gaston, Jonathan S. Stamler, Owen W. Griffith
  • Patent number: 6617355
    Abstract: Asthma is ameliorated, and mild or moderate asthma is prevented from progressing to more severe asthma by administering agents which prevent and/or accommodate for S-nitrosothiol breakdown.
    Type: Grant
    Filed: November 4, 1999
    Date of Patent: September 9, 2003
    Assignees: The University of Virginia Patent Foundation, Duke University, The Medical College of Wisconsin Research Foundation, Inc.
    Inventors: Benjamin Gaston, Jonathan S. Stamler, Owen W. Griffith