Patents by Inventor Benjamin George Keselowsky

Benjamin George Keselowsky has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Microparticle systems and their use for the treatment of multiple sclerosis
    Patent number: 12109271
    Abstract: Provided are a dual microparticle system to treat Multiple Sclerosis, the system comprising phagocytosable and non-phagocytosable microparticles for delivery of at least one antigen, at least one immunomodulatory agent, at least one immunosuppressive agent and at least one chemoattractant to a subject suffering from Multiple Sclerosis to generate tolerogenic dendritic cells in the subject and treat the Multiple Sclerosis.
    Type: Grant
    Filed: July 3, 2019
    Date of Patent: October 8, 2024
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventors: Dorina Avram, Benjamin George Keselowsky, Joshua Stewart, Jonathan Joseph Cho
  • MICROPARTICLE SYSTEMS AND THEIR USE FOR THE TREATMENT OF MULTIPLE SCLEROSIS
    Publication number: 20210169904
    Abstract: Provided are a dual microparticle system to treat Multiple Sclerosis, the system comprising phagocytosable and non-phagocytosable microparticles for delivery of at least one antigen, at least one immunomodulatory agent, at least one immunosuppressive agent and at least one chemoattractant to a subject suffering from Multiple Sclerosis to generate tolerogenic dendritic cells in the subject and treat the Multiple Sclerosis.
    Type: Application
    Filed: July 3, 2019
    Publication date: June 10, 2021
    Inventors: Dorina AVRAM, Benjamin George KESELOWSKY, Joshua STEWART, Jonathan Joseph CHO
  • Antigen-specific, tolerance-inducing microparticles and uses thereof
    Patent number: 10987314
    Abstract: The present invention provides antigen-specific, tolerance-inducing microparticles for the targeted delivery of therapeutic agents to immune cells. In addition, the present invention allows for sustained release of therapeutic agents for a prolonged period of time. Also provided are therapeutic uses of the present invention for the prevention and/or treatment of immune diseases and autoimmune disorders. In a specific embodiment, the present invention provides treatment for type 1 diabetes.
    Type: Grant
    Filed: July 1, 2018
    Date of Patent: April 27, 2021
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Benjamin George Keselowsky, Jamal Lewis, Abhinav Acharya, Michael J. Clare-Salzler
  • MATERIALS AND METHODS FOR MODULATING IMMUNE RESPONSES
    Publication number: 20180311344
    Abstract: The present invention provides materials and methods for modulating an immune response. In one embodiment, the present invention provides an initial artificial lymph-node homing environment, and a simultaneous, or subsequent, artificial spleen environment leading to the resolution of the activated immune responses. In one specific embodiment, the present invention can be used to prevent and/or treat pathogenic infection, cancer, allergenic reactions, and/or unwanted immune or auto-immune responses.
    Type: Application
    Filed: July 16, 2018
    Publication date: November 1, 2018
    Inventors: Clive Henry WASSERFALL, Mark A. ATKINSON, Benjamin George KESELOWSKY, Young Mee YOON
  • ANTIGEN-SPECIFIC, TOLERANCE-INDUCING MICROPARTICLES AND USES THEREOF
    Publication number: 20180303760
    Abstract: The present invention provides antigen-specific, tolerance-inducing microparticles for the targeted delivery of therapeutic agents to immune cells. In addition, the present invention allows for sustained release of therapeutic agents for a prolonged period of time. Also provided are therapeutic uses of the present invention for the prevention and/or treatment of immune diseases and autoimmune disorders. In a specific embodiment, the present invention provides treatment for type 1 diabetes.
    Type: Application
    Filed: July 1, 2018
    Publication date: October 25, 2018
    Inventors: BENJAMIN GEORGE KESELOWSKY, JAMAL LEWIS, ABHINAV ACHARYA, MICHAEL J. CLARE-SALZLER
  • Materials and methods for modulating immune responses
    Patent number: 10022440
    Abstract: The present invention provides materials and methods for modulating an immune response. In one embodiment, the present invention provides an initial artificial lymph-node homing environment, and a simultaneous, or subsequent, artificial spleen environment leading to the resolution of the activated immune responses. In one specific embodiment, the present invention can be used to prevent and/or treat pathogenic infection, cancer, allergenic reactions, and/or unwanted immune or auto-immune responses.
    Type: Grant
    Filed: June 25, 2012
    Date of Patent: July 17, 2018
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED
    Inventors: Clive Henry Wasserfall, Mark A. Atkinson, Benjamin George Keselowsky, Young Mee Yoon
  • Antigen-specific, tolerance-inducing microparticles and uses thereof
    Patent number: 10016371
    Abstract: The present invention provides antigen-specific, tolerance-inducing microparticles for the targeted delivery of therapeutic agents to immune cells. In addition, the present invention allows for sustained release of therapeutic agents for a prolonged period of time. Also provided are therapeutic uses of the present invention for the prevention and/or treatment of immune diseases and autoimmune disorders. In a specific embodiment, the present invention provides treatment for type 1 diabetes.
    Type: Grant
    Filed: October 24, 2011
    Date of Patent: July 10, 2018
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION
    Inventors: Benjamin George Keselowsky, Jamal Lewis, Abhinav Acharya, Michael J. Clare-Salzler
  • Bioresorbable metal alloy and implants made of same
    Patent number: 9629873
    Abstract: Disclosed herein is a non-toxic, bioresorbable, magnesium based alloy for use in production of implants. Specifically exemplified herein are alloy embodiments useful for orthopedic implants. Also disclosed are alloy materials that incorporate magnesium, calcium and strontium.
    Type: Grant
    Filed: July 2, 2011
    Date of Patent: April 25, 2017
    Assignee: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Michele Viola Manuel, Harpreet Singh Brar, Ida Svensson Berglund, Benjamin George Keselowsky, Malisa Sarntinoranont
  • Cell-based arrays, methods of making, and methods of using
    Patent number: 9557319
    Abstract: Embodiments of the present disclosure provide for arrays, systems, and methods analyzing cells, methods of making arrays, and the like.
    Type: Grant
    Filed: May 22, 2014
    Date of Patent: January 31, 2017
    Assignee: University of Florida Research Foundation, Inc.
    Inventors: Benjamin George Keselowsky, Abhinav Prakash Acharya, Emina Huang, Edward William Scott, Matthew Carstens
  • CELL-BASED ARRAYS, METHODS OF MAKING, AND METHODS OF USING
    Publication number: 20160349241
    Abstract: Embodiments of the present disclosure provide for arrays, systems, and methods analyzing cells, methods of making arrays, and the like.
    Type: Application
    Filed: May 22, 2014
    Publication date: December 1, 2016
    Inventors: Benjamin George Keselowsky, Abhinav Prakash Acharya, Emina Huang, Edward William Scott, Matthew Carstens
  • Materials and Methods for Modulating immune Responses
    Publication number: 20150147388
    Abstract: The present invention provides materials and methods for modulating an immune response. In one embodiment, the present invention provides an initial artificial lymph-node homing environment, and a simultaneous, or subsequent, artificial spleen environment leading to the resolution of the activated immune responses. In one specific embodiment, the present invention can be used to prevent and/or treat pathogenic infection, cancer, allergenic reactions, and/or unwanted immune or auto-immune responses.
    Type: Application
    Filed: June 25, 2012
    Publication date: May 28, 2015
    Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Clive Henry Wasserfall, Mark A. Atkinson, Benjamin George Keselowsky, Young Mee Yoon
  • Cell-based arrays, methods of making, and methods of using
    Patent number: 9012202
    Abstract: Embodiments of the present disclosure provide for arrays, systems, and methods for the analyzing cells, methods of making arrays, and the like.
    Type: Grant
    Filed: November 2, 2011
    Date of Patent: April 21, 2015
    Inventors: Benjamin George Keselowsky, Abhinav Prakash Acharya, Emina Huang, Edward William Scott, Matthew Carstens
  • CELL-BASED ARRAYS, METHODS OF MAKING, AND METHODS OF USING
    Publication number: 20140323353
    Abstract: Embodiments of the present disclosure provide for arrays, systems, and methods analyzing cells, methods of making arrays, and the like.
    Type: Application
    Filed: May 22, 2014
    Publication date: October 30, 2014
    Inventors: Benjamin George Keselowsky, Abhinav Prakash Acharya, Emina Huang, Edward William Scott, Matthew Carstens
  • BIORESORBABLE METAL ALLOY AND IMPLANTS MADE OF SAME
    Publication number: 20140154341
    Abstract: Disclosed herein is a non-toxic, bioresorbable, magnesium based alloy for use in production of implants. Specifically exemplified herein are alloy embodiments useful for orthopedic implants. Also disclosed are alloy materials that incorporate magnesium, calcium and strontium.
    Type: Application
    Filed: July 2, 2011
    Publication date: June 5, 2014
    Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Michele Viola Manuel, Harpreet Singh Brar, Ida Svensson Berglund, Benjamin George Keselowsky, Malisa Sarntinoranont
  • ANTIGEN-SPECIFIC, TOLERANCE-INDUCING MICROPARTICLES AND USES THEREOF
    Publication number: 20130287729
    Abstract: The present invention provides antigen-specific, tolerance-inducing microparticles for the targeted delivery of therapeutic agents to immune cells. In addition, the present invention allows for sustained release of therapeutic agents for a prolonged period of time. Also provided are therapeutic uses of the present invention for the prevention and/or treatment of immune diseases and autoimmune disorders. In a specific embodiment, the present invention provides treatment for type 1 diabetes.
    Type: Application
    Filed: October 24, 2011
    Publication date: October 31, 2013
    Applicant: UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC.
    Inventors: Benjamin George Keselowsky, Jamal` Lewis, Abhinav Acharya, Michael J. Clare-Salzler, Mark A. Atkinson, Clive Henry Wasserfall, Chang Qing Xia, Todd M. Brusko
  • Cell-based arrays, methods of making, and methods of using
    Publication number: 20120108468
    Abstract: Embodiments of the present disclosure provide for arrays, systems, and methods for the analyzing cells, methods of making arrays, and the like.
    Type: Application
    Filed: November 2, 2011
    Publication date: May 3, 2012
    Applicant: University of Florida Research Foundation, Inc.
    Inventors: Benjamin George Keselowsky, Abhinav Prakash Acharya, Emina Huang, Edward William Scott, Matthew Carstens
  • NANOROD MATERIALS AND METHODS OF MAKING AND USING SAME
    Publication number: 20110091510
    Abstract: The subject invention concerns nanorods, compositions and substrates comprising nanorods, and methods of making and using nanorods and nanorod compositions and substrates. In one embodiment, the nanorod is composed of Zinc oxide (ZnO). In a further embodiment, a nanorod of the invention further comprises SiO2 or TiO2. In a specific embodiment, a nanorod of the invention is composed of ZnO coated with SiO2. Nanorods of the present invention are useful as an adhesion-resistant biomaterial capable of reducing viability in anchorage-dependent cells.
    Type: Application
    Filed: April 30, 2009
    Publication date: April 21, 2011
    Inventors: Tanmay P. Lele, Fan Ren, Benjamin George Keselowsky, Jiyeon Lee, Anand Gupte, Byung-Hwan Chu, Karl Zawoy