Patents by Inventor Benjamin Gerwat

Benjamin Gerwat has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Chromatography equipment characterization
    Patent number: 9047438
    Abstract: Herein is reported a method for determining whether a re-usable chromatography column packing, which is used at least for the second time in a purification step of a purification of a polypeptide, has reduced separation efficacy in said purification step of said purification of said polypeptide, comprising the following steps: a) identifying and determining the experimental data of an inert change of at least one physicochemical parameter of a mobile phase passing through said re-usable chromatography column packing, b) determining the parameters of a function of formula I by fitting the experimental data of the inert change of the physicochemical parameter of the at least second use, c) determining the difference between the experimental data of the inert change of the physicochemical parameter of the at least second use and the function of formula I with the parameters determined in step b), d) calculating the difference between the maximum value and the minimum value of the difference determined in step c)
    Type: Grant
    Filed: June 19, 2013
    Date of Patent: June 2, 2015
    Assignee: Hoffmann-La-Roche, Inc.
    Inventors: Anton Belousov, Thomas Dams, Benjamin Gerwat
  • Chromatography Equipment Characterization
    Publication number: 20130281672
    Abstract: Herein is reported a method for determining whether a re-usable chromatography column packing, which is used at least for the second time in a purification step of a purification of a polypeptide, has reduced separation efficacy in said purification step of said purification of said polypeptide, comprising the following steps: a) identifying and determining the experimental data of an inert change of at least one physicochemical parameter of a mobile phase passing through said re-usable chromatography column packing, b) determining the parameters of a function of formula I by fitting the experimental data of the inert change of the physicochemical parameter of the at least second use, c) determining the difference between the experimental data of the inert change of the physicochemical parameter of the at least second use and the function of formula I with the parameters determined in step b), d) calculating the difference between the maximum value and the minimum value of the difference determined in step c)
    Type: Application
    Filed: June 19, 2013
    Publication date: October 24, 2013
    Inventors: Anton Belousov, Thomas Dams, Benjamin Gerwat
  • Chromatography equipment characterization
    Patent number: 8357301
    Abstract: Herein is reported a method for determining whether a re-useable chromatography column packing, which is used at least for the second time in a purification step of a purification of a polypeptide, has reduced separation efficacy in said purification step of said purification of said polypeptide, comprising the following steps: a) identifying and determining the experimental data of an inert change of at least one physicochemical parameter of a mobile phase passing through said re-useable chromatography column packing, b) determining the parameters of a function of formula I by fitting the experimental data of the inert change of the physicochemical parameter of the at least second use, c) determining the difference between the experimental data of the inert change of the physicochemical parameter of the at least second use and the function of formula I with the parameters determined in step b), d) calculating the difference between the maximum value and the minimum value of the difference determined in step
    Type: Grant
    Filed: June 22, 2010
    Date of Patent: January 22, 2013
    Assignee: Hoffmann-La Roche, Inc.
    Inventors: Anton Belousov, Thomas Dams, Benjamin Gerwat
  • CHROMATOGRAPHY EQUIPMENT CHARACTERIZATION
    Publication number: 20120202978
    Abstract: Herein is reported a method for determining whether a re-useable chromatography column packing, which is used at least for the second time in a purification step of a purification of a polypeptide, has reduced separation efficacy in said purification step of said purification of said polypeptide, comprising the following steps: a) identifying and determining the experimental data of an inert change of at least one physicochemical parameter of a mobile phase passing through said re-useable chromatography column packing, b) determining the parameters of a function of formula I by fitting the experimental data of the inert change of the physicochemical parameter of the at least second use, c) determining the difference between the experimental data of the inert change of the physicochemical parameter of the at least second use and the function of formula I with the parameters determined in step b), d) calculating the difference between the maximum value and the minimum value of the difference determined in step
    Type: Application
    Filed: June 22, 2010
    Publication date: August 9, 2012
    Applicant: HOFFMANN-LA ROCHE, INC,
    Inventors: Anton Belousov, Thomas Dams, Benjamin Gerwat