Abstract: Certain aspects of this disclosure are generally related to methods for separating a plurality of particles from a fluid. In some embodiments, the fluid comprises one or more polypeptides and a plurality of particles. In some embodiments, the method comprises at least partially denaturing a polypeptide in the fluid to form a denatured polypeptide. In some embodiments, the method comprises separating a mixture of the denatured polypeptide and at least 10% of a plurality of particles from the fluid. Without wishing to be bound by any particular theory, the denaturation of the polypeptide in the fluid may allow for some of the plurality of particles to associate with the denatured polypeptide, and/or agglomerate with the denatured polypeptide. The mixture comprising the denatured polypeptide and the plurality of particles may settle (e.g., precipitate) in the fluid and may therefore be separated from the fluid.

Abstract: A method of inhibiting KIF15 can include administering a compound to the KIF15 to inhibit biological functionality of KIF15. The compound includes a structure of Formula 1. R1 and R2 are each independently a non-hydrogen substituent, such that the compound inhibits biological functionality of KIF15, or a stereoisomeric form or a mixture of stereoisomeric forms, or pharmaceutically acceptable salts of the compound. The compound is administered to the KIF15 to inhibit KIF15 from interacting with TPX2 so as to inhibit or disrupt a protein-protein interaction therebetween. The administering of the compound can be to a subject having the KIF15, which is administered in a therapeutically effective amount to treat a disease or disorder associated with KIF15 interacting with TPX2, such as treating a cancer or neoplasm.

Abstract: Systems, methods, and compositions relating to pretreatment and enzymatic degradation of polymeric materials comprising one or more crystallizable polymers or copolymers are generally described. Certain aspects are directed to methods comprising reacting a polymeric material comprising a crystallizable polymer or copolymer with a reactive agent to produce a pretreated polymeric material and exposing the pretreated polymeric material to a polymer-degrading enzyme. In some embodiments, the reactive agent induces chain extension, branching, and/or cross-linking of the crystallizable polymer or copolymer. In some embodiments, the reactive agent induces chain scissions followed by chain extension, branching, and/or cross-linking of the crystallizable polymer or copolymer.

Abstract: Systems, methods, and compositions relating to pretreatment and enzymatic degradation of polymeric materials comprising one or more crystallizable polymers or copolymers are generally described. Certain aspects are directed to methods comprising reacting a polymeric material comprising a crystallizable polymer or copolymer with a reactive agent to produce a pretreated polymeric material and exposing the pretreated polymeric material to a polymer-degrading enzyme. In some embodiments, the reactive agent induces chain extension, branching, and/or cross-linking of the crystallizable polymer or copolymer. In some embodiments, the reactive agent induces chain scissions followed by chain extension, branching, and/or cross-linking of the crystallizable polymer or copolymer.

Abstract: Systems, methods, and compositions relating to pretreatment and enzymatic degradation of polymeric materials comprising one or more crystallizable polymers or copolymers are generally described. Certain aspects are directed to methods comprising reacting a polymeric material comprising a crystallizable polymer or copolymer with a reactive agent to produce a pretreated polymeric material and exposing the pretreated polymeric material to a polymer-degrading enzyme. In some embodiments, the reactive agent induces chain extension, branching, and/or cross-linking of the crystallizable polymer or copolymer. In some embodiments, the reactive agent induces chain scissions followed by chain extension, branching, and/or cross-linking of the crystallizable polymer or copolymer.

Abstract: A bridge-supported tool for opening and closing lids located on top of railcars. The bridge has two sides and a cross member between the sides that moves along the sides, the cross member supports a tool carriage that moves along the cross member, the tool carriage has a tool engagement interface for retaining a selected tool and the interface is vertically moveable, such that the tool is moveable to any selected location in the space defined by the bridge. A controller can be used to direct the positioning of the tool by controlling the movements of the cross member, tool carriage and tool engagement interface.

Abstract: A bridge-supported tool for opening and closing lids located on top of railcars. The bridge has two sides and a cross member between the sides that moves along the sides, the cross member supports a tool carriage that moves along the cross member, the tool carriage has a tool engagement interface for retaining a selected tool and the interface is vertically moveable, such that the tool is moveable to any selected location in the space defined by the bridge. A controller can be used to direct the positioning of the tool by controlling the movements of the cross member, tool carriage and tool engagement interface.

Abstract: Various aspects of the disclosure relate to determining whether a signal detection function is properly detecting for a signal. In an example implementation, the signal detection function detects radar signals. If the signal detection function is not functioning as desired, communication on at least one wireless communication channel may be disabled.

Abstract: The present invention provides virtual batteries for a wireless communication device. Generally speaking, a virtual battery is a logical construct on a wireless communication device that powers a defined set of wireless communication device applications and has a defined power budget from one or more physical batteries on the device. Through judicious assignment of wireless communication device applications and power budgets to virtual batteries, a user of a wireless communication device can efficiently allocate power among competing wireless communication device applications.

Abstract: A mobile telecommunications device configured for use in a wireless communication system is disclosed that includes a processor and memory in electronic communication with the processor. Instructions are stored in the memory. The instructions are executable to implement a method for call screening. An incoming call is received from a caller. The incoming call is answered and put on hold. Voicemail is dialed into such that the voicemail call does not automatically go into the voicemail retrieval menu. The incoming call and the voicemail call are joined into a three-way conference call such that a user of the mobile telecommunications device is able to screen the incoming call.

Abstract: A default recipient of a message and/or photograph sent from a mobile camera telephone is determined based on one of several alternative techniques. In one technique, the default recipient could be a preselected default recipient. In another alternative technique, the default recipient could be determined based on a most recent recipient of another message and/or photograph. As yet another alternative technique, the default recipient could be determined based on a recipient contained in a send-to list that has received a most number of messages and/or photographs. Still another alternative provides that the default recipient is determined in response to actuation of a selected key of the mobile telephone that corresponds to the default recipient.

Abstract: An international telephone number is displayed by automatically inserting at least one space after the country code portion of the telephone number. In particular, when a telephone number having an International Direct Dialing (IDD) prefix, such as “00”, “011” and “+”, is received, the telephone number is then displayed by inserting at least one space between a country code portion contained in the telephone number and subsequent numbers of the telephone number. The country code portion of the telephone number is determined by accessing a look-up table for identifying the country code portion of the telephone number. Alternatively, the country code portion could be determined by comparing numbers appearing subsequent to the IDD prefix with predetermined country codes.