Abstract: Disclosed are compounds of Formula (I): or pharmaceutically acceptable salts or solvates thereof, wherein R1, R3, X, Y, Z, and W are as defined herein. The compounds are, for example, inhibitors of WRN helicase and useful in treating a proliferative disease, such as cancer.

Abstract: Described are systems and methods directed to a multi-channel communication system that enables real-time or near real-time communication between two or more individuals, such as a patient and a clinician in which at least one of the individuals uses one device for audio/video communication and another device for exchange of data, such as annotated images. For example, a patient may utilize a patient device to communicate with a clinician via a first clinician device. In addition to the first clinician device, the clinician may also use a second clinician device to annotate and share visual data, such as templates or patient images, with the patient, without disrupting the audio/video communication between the patient device and the first clinician device.

Abstract: Hand sanitizer formulations described herein include sensory enhancing and/or moisturizing ingredients but lack emulsification systems. Exemplary hand sanitizer formulations include low molecular weight alkanes/mineral oils, high emollient loadings which build viscosity and allow for shake-and-use products, and density equalization technology that allows for robust delivery of homogenous product in a shake-and-use formulation.

Abstract: Information is presented on a map that resembles a city map, with related information grouped into distinct “neighborhoods.” Such a display scheme takes advantage of spatial cognition in order to provide an organizational and presentational scheme by which users can more easily remember where to look for and find the right information. Metadata, notifications, and/or other auxiliary information can be presented alongside or superimposed upon the data itself.

Abstract: A removable and machine-washable automobile mat assembly, wherein the assembly having an upper mat and a lower mat and an interlocking means of attachment configured to removably attach the upper and lower mats.

Abstract: Information is presented on a map that resembles a city map, with related information grouped into distinct “neighborhoods.” Such a display scheme takes advantage of spatial cognition in order to provide an organizational and presentational scheme by which users can more easily remember where to look for and find the right information. Metadata, notifications, and/or other auxiliary information can be presented alongside or superimposed upon the data itself.

Abstract: Systems and methods are described for providing content recommendations by maintaining preference values indicative of a user's preference (e.g., degree of like or dislike) for different assets and updating these preference values based on observed events and known relationships between events and content elements. Also disclosed herein are systems and methods for providing content recommendations using polarity scores, which represent how much user preferences for certain content differ from the average user preference for that content.

Abstract: Systems and methods are provided for cataloging content metadata from a variety of sources and providing metadata to client devices. A processing device receives inconsistent data records representative of a common content element, with different values for a metadata field descriptive of a common attribute of the content element. The processor assign confidence scores metadata fields from each data record, and use these confidence scores to select the metadata that is transmitted to the client device.

Abstract: Systems and methods are described for providing content recommendations by maintaining preference values indicative of a user's preference (e.g., degree of like or dislike) for different assets and updating these preference values based on observed events and known relationships between events and content elements. Also disclosed herein are systems and methods for providing content recommendations using polarity scores, which represent how much user preferences for certain content differ from the average user preference for that content.

Abstract: Systems and methods are provided for identifying a content domain associated with seed information, and searching metadata based on seed information. A processor receives seed information and accesses a database of tokens, each token associated with a content domain and each content domain associated with two or more tokens. For example, the content domain may be “Music” and the token may include “feat,” “with,” or “duet.” The processor determines whether a portion of the seed information matches a token in the database of tokens, and in response to determining that a portion of the seed information matches a token, the processor identifies the content domain associated with the matching token and determines whether at least some of the seed information, including the matching token, corresponds to some of the metadata in a database of data records.

Abstract: A portable surveillance system for rapid deployment, comprising a hardware case containing a battery, a processor, a hard disk drive, and a means for communications; at least one surveillance camera; and a tripod. The tripod is used to support both the camera and the hardware case. The hardware case is weatherproof, having intake and exhaust fans and optional electric heating and/or cooling units. The present invention is capable of being transported and positioned quickly by a single operator in a desired location.

Abstract: The present invention provides a self-contained covert surveillance system, comprising an enclosure having an outside appearance resembling a utility box and containing therein at least one camera, a processor, a data storage device, and a means for communications, wherein the enclosure has at least one surface that allows light to penetrate the surface and be captured by the camera. The invention may be further equipped With intake and exhaust fans and/or electric heating and cooling devices to expand the utility of the device to more extreme environmental conditions.

Abstract: A portable surveillance system for rapid deployment, comprising a hardware case containing a battery, a processor, a hard disk drive, and a means for communications; at least one surveillance camera; and a tripod. The tripod is used to support both the camera and the hardware case. The hardware case is weatherproof, having intake and exhaust fans and optional electric heating and/or cooling units. The present invention is capable of being transported and positioned quickly by a single operator in a desired location.

Abstract: A vent for a mold having a mold cavity comprising a vent main body, a valve closure member having an upper end face for positioning at the surface of the mold cavity, the valve closure member being moveable with respect to the vent main body for opening and closing the vent, a spring opening mechanism formed integrally with the vent main body for opening the vent, and a valve seat between the valve closure member and the main body wherein the vent is closed by material in the mold cavity contacting the upper end face of the valve closure member.

Abstract: A vent for a mold comprising a valve closure member and integrally formed spring opening mechanism for opening the valve closure member such that when mounted in an air release vent the valve closure member may open or close said vent.