Patents by Inventor Benjamin Hackel

Benjamin Hackel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20240285676
    Abstract: The present disclosure relates to bottlebrush polymers and methods thereof. Methods can include methods of stabilizing an interface, stabilizing a cell, or treating a disease, disorder, or condition using an effective amount of the bottlebrush polymer.
    Type: Application
    Filed: February 9, 2024
    Publication date: August 29, 2024
    Inventors: Joseph Franklin Hassler, Adelyn Crabtree, Benjamin Hackel, Frank S. Bates, Timothy P. Lodge, Joseph M. Metzger
  • Patent number: 11965190
    Abstract: Provided herein are a vector, a genetically modified bacterium including the vector, methods of making the bacterium, methods of using the bacterium, and kits including the bacterium. The vector includes a coding region encoding at least one antimicrobial peptide, and the antimicrobial peptide includes at least one lysin.
    Type: Grant
    Filed: September 7, 2018
    Date of Patent: April 23, 2024
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Yiannis John Kaznessis, Seth Ritter, Benjamin Hackel
  • Patent number: 11891426
    Abstract: CD19 variants, methods of identifying CD19 variants, and methods of using such CD19 variants, e.g., for treating cancer, are described.
    Type: Grant
    Filed: December 14, 2018
    Date of Patent: February 6, 2024
    Assignees: Aleta Biotherapeutics Inc., Regents of The University of Minnesota
    Inventors: Roy Lobb, Paul Rennert, Benjamin Hackel, Justin Klesmith
  • Publication number: 20230312737
    Abstract: Certain embodiments of the invention provide helix sequences that have affinity for Death Receptor 5 (DR5). Certain embodiments of the invention provide an isolated anti-DR5 polypeptide (e.g., affibody for DR5) that modulates the activity and/or conformation of DR5. Certain embodiments of the invention provide methods of noncompetitively inhibiting DR5 and/or treating a fatty liver disorder.
    Type: Application
    Filed: March 3, 2021
    Publication date: October 5, 2023
    Applicant: Regents of the University of Minnesota
    Inventors: Benjamin HACKEL, Jonathan N. SACHS, Nagamani VUNNAM
  • Publication number: 20210269786
    Abstract: Provided herein are a vector, a genetically modified bacterium including the vector, methods of making the bacterium, methods of using the bacterium, and kits including the bacterium. The vector includes a coding region encoding at least one antimicrobial peptide, and the antimicrobial peptide includes at least one lysin.
    Type: Application
    Filed: September 7, 2018
    Publication date: September 2, 2021
    Inventors: Yiannis John Kaznessis, Seth Ritter, Benjamin Hackel
  • Publication number: 20210079060
    Abstract: CD19 variants, methods of identifying CD19 variants, and methods of using such CD19 variants, e.g., for treating cancer, are described.
    Type: Application
    Filed: December 14, 2018
    Publication date: March 18, 2021
    Inventors: Roy Lobb, Paul Rennert, Benjamin Hackel, Justin Klesmith
  • Patent number: 10787499
    Abstract: Certain embodiments of the invention provide epithelial cell adhesion molecule (EpCAM) binding polypeptides, as well as conjugates and CSANs comprising such polypeptides. Additionally, certain embodiments of the invention also provide methods of using such polypeptides and compounds for molecular imaging and molecularly targeted therapies.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: September 29, 2020
    Assignee: REGENTS OF THE UNIVERSITY OF MINNESOTA
    Inventors: Benjamin Hackel, Carston R. Wagner, Lawrence A. Stern, Clifford Csizmar
  • Publication number: 20200299665
    Abstract: Provided herein are a vector, a genetically modified bacterium including the vector, methods of making the bacterium, methods of using the bacterium, and kits including the bacterium. The vector includes a coding region encoding at least one antimicrobial peptide, and the antimicrobial peptide includes at least one lysin.
    Type: Application
    Filed: September 7, 2018
    Publication date: September 24, 2020
    Inventors: Yiannis John Kaznessis, Seth Ritter, Benjamin Hackel
  • Publication number: 20180251524
    Abstract: Certain embodiments of the invention provide epithelial cell adhesion molecule (EpCAM) binding polypeptides, as well as conjugates and CSANs comprising such polypeptides. Additionally, certain embodiments of the invention also provide methods of using such polypeptides and compounds for molecular imaging and molecularly targeted therapies.
    Type: Application
    Filed: February 13, 2018
    Publication date: September 6, 2018
    Inventors: Benjamin Hackel, Carston R. Wagner, Lawrence A. Stern, Clifford Csizmar
  • Patent number: 9433689
    Abstract: Embodiments of the present disclosure provide for labeled probes such as a 64Cu-FN3 probe (FN3 refers to fibronectin type 3 domain); methods of making labeled probes; pharmaceutical compositions including labeled probes; methods of using labeled probes; methods of diagnosing, localizing, monitoring, and/or assessing non-Hodgkin's lymphoma, cancers, tumors, precancerous cells, and related biological events using labeled probes; kits for diagnosing, localizing, monitoring, and/or assessing non-Hodgkin's lymphoma, cancers, tumors, precancerous cells, and related biological events; and the like.
    Type: Grant
    Filed: March 11, 2014
    Date of Patent: September 6, 2016
    Assignee: The Board of Trustees of the Leland Stanford Junio
    Inventors: Benjamin Hackel, Arutselvan Natarajan, Sanjiv S. Gambhir
  • Publication number: 20140271467
    Abstract: Embodiments of the present disclosure provide for labeled probes such as a 64Cu-FN3 probe (FN3 refers to fibronectin type 3 domain); methods of making labeled probes; pharmaceutical compositions including labeled probes; methods of using labeled probes; methods of diagnosing, localizing, monitoring, and/or assessing non-Hodgkin's lymphoma, cancers, tumors, precancerous cells, and related biological events using labeled probes; kits for diagnosing, localizing, monitoring, and/or assessing non-Hodgkin's lymphoma, cancers, tumors, precancerous cells, and related biological events; and the like.
    Type: Application
    Filed: March 11, 2014
    Publication date: September 18, 2014
    Inventors: Benjamin Hackel, Arutselvan Natarajan, Sanjiv S. Gambhir