Abstract: The invention relates to double-stranded ribonucleic acid (dsRNA) compositions targeting the plasminogen (PLG) gene, as well as methods of inhibiting expression of PLG, and methods of treating subjects that would benefit from reduction in expression of PLG, such as subjects having a PLG-associated disease, disorder, or condition, using such dsRNA compositions.

Abstract: A deep vein intravenous introducer has a wheel located toward the front end of the device that can be rotated by the index finger of the user. After placement of the needle in the lumen of the vessel, the user rotates the wheel, which advances the wire guide through the center of the needle and into the patient. Once the guide wire is advanced into the vessel lumen the catheter can be advanced over the guide wire with a hub or finger tab on the catheter close to the index finger. The operation can be performed by one hand without moving the hand from its initial position. The user can then simultaneously use the other hand to operate an ultrasound detection device during insertion without the assistance of another person.

Abstract: The present disclosure relates to a three-dimensionally (e.g., 3D) printed, surgically implantable tissue engineering scaffolds for promoting bone, vascular, and/or cartilage regeneration at osteochondral regions and a method for manufacturing the 3D printed surgically implantable tissue engineering scaffold. The 3D printed surgically implantable tissue engineering scaffold may be fabricated at least in part from a thermoplastic polyurethane (e.g., nTPU) composite via a rapid prototyping machine. In some cases, the three-dimensional shape of the fabricated tissue engineering scaffold may correspond to a three-dimensional shape of a tissue defect of a patient.

Abstract: Embodiments of the present invention relate to structures and systems having a three-dimensional biomimetic structure with a porous biomimetic three-dimensional scaffold and a coating deposited onto a surface of the porous biomimetic three-dimensional scaffold as well as methods of using and fabricating the like.

Abstract: A deep vein intravenous introducer has a wheel located toward the front end of the device that can be rotated by the index finger of the user. After placement of the needle in the lumen of the vessel, the user rotates the wheel, which advances the wire guide through the center of the needle and into the patient. Once the guide wire is advanced into the vessel lumen the catheter can be advanced over the guide wire with a hub or finger tab on the catheter close to the index finger. The operation can be performed by one hand without moving the hand from its initial position. The user can then simultaneously use the other hand to operate an ultrasound detection device during insertion without the assistance of another person. A catheter is provided that can be visualized by ultrasound to enable confirmation of correct placement in a vessel. A probe cover is provided that is pre-sterilized and packaged in a cardboard with the top sides of the cover folded down over the cardboard.

Abstract: A deep vein intravenous introducer has a wheel located toward the front end of the device that can be rotated by the index finger of the user. After placement of the needle in the lumen of the vessel, the user rotates the wheel, which turns a drive wheel. The drive wheel has an outer surface that advances the guide wire through the center of the needle and into the patient. Once the guide wire is advanced into the vessel lumen the catheter can be advanced over the guide wire with a hub or finger tab on the catheter close to the index finger. The operation can be performed by one hand without moving the hand from its initial position.

Abstract: A deep vein intravenous introducer has a wheel located toward the front end of the device that can be rotated by the index finger of the user. After placement of the needle in the lumen of the vessel, the user rotates the wheel, which advances the wire guide through the center of the needle and into the patient. Once the guide wire is advanced into the vessel lumen the catheter can be advanced over the guide wire with a hub or finger tab on the catheter close to the index finger. The operation can be performed by one hand without moving the hand from its initial position. The user can then simultaneously use the other hand to operate an ultrasound detection device during insertion without the assistance of another person. A catheter is provided that can be visualized by ultrasound to enable confirmation of correct placement in a vessel.

Abstract: A vending machine (105) includes an enclosure configured to store products for a vending transaction. A user interface (215) of the vending machine (105) is configured to display, on a display screen, content for viewing and a recommendation for one or more products. Content includes one or more of a poll, an advertisement, a product selection menu, a payment selection menu, a product purchase display queue, or a transaction complete display queue. A control system (300) is configured to receive at least one recommendation input based on displaying the content, product information of one or more products, and at least one recommendation rule. The control system (300) is also configured to generate for display, on the display screen, the recommendation for one or more products based on the at least one recommendation input, the product information of the one or more products, and the at least one recommendation rule.

Abstract: Embodiments of the present invention relate to structures and systems having a three-dimensional biomimetic structure with a porous biomimetic three-dimensional scaffold and a coating deposited onto a surface of the porous biomimetic three-dimensional scaffold as well as methods of using and fabricating the like.

Abstract: A deep vein intravenous introducer has a wheel located toward the front end of the device that can be rotated by the index finger of the user. After placement of the needle in the lumen of the vessel, the user rotates the wheel, which advances the wire guide through the center of the needle and into the patient. Once the guide wire is advanced into the vessel lumen the catheter can be advanced over the guide wire with a hub or finger tab on the catheter close to the index finger. The operation can be performed by one hand without moving the hand from its initial position. The user can then simultaneously use the other hand to operate an ultrasound detection device during insertion without the assistance of another person. A catheter is provided that can be visualized by ultrasound to enable confirmation of correct placement in a vessel. A probe cover is provided that is pre-sterilized and packaged in a cardboard with the top sides of the cover folded down over the cardboard.

Abstract: A catheter can be used in arterial and/or venous placement, in conjunction with ultrasound positioning. The catheter itself is made of the same materials, and is sized using the standard gauges, as current existing catheters. However, the catheter has a microtexture on the outer surface of the catheter. This microtexture efficiently and effectively reflects propagated ultrasound waves in situ, to provide a brighter and clearer image of the catheter when being placed in a patient's vessel, with ultrasound imaging equipment.

Abstract: A flexible circuit having improved tear resistance is provided. A flexible circuit, made of polyimide film, includes at least one extension which needs to be folded. To prevent tearing, an annular piece of metal, like an exposed copper pad for example, is placed at the apex of the bend angle. A second metal is then deposited atop the annular piece of metal, thereby reinforcing the annular piece of metal. The reinforced annular piece of metal helps to prevent the flexible circuit from tearing when shearing forces are applied to the extension. Experimental results have shown that the invention provides as much as a 285% increase in tear resistance when compared to prior art flexible circuits.