Abstract: Systems and methods related to recalibrating neural devices based on external sensory information are disclosed. The systems can include a neural device configured to sense data associated with the subject or receive control input, a sensor communicably coupled to the external device, the sensor configured to detect a state associated with the subject, and an external device communicably coupled to the neural device and the sensor. The external device can recalibrate a neural decoding model based on the state detected via the sensor, wherein the neural decoding model correlates the data received from the neural device with a corresponding thought or action performed by the subject.

Abstract: A device and system for real-time visualization of the electrophysiologic activity of a brain, particularly at the cortical surface. The neural device can acquire, process, and display high-spatiotemporal-resolution electrophysiologic data in real-time across entire electrode arrays spanning many thousands of electrodes over identified anatomic regions. The system is compatible with thin-film cortical surface electrodes that record from neural tissues without damaging those tissues. The system can be used to guide diagnostic and therapeutic actions with high precision, and also provides the basis for a brain-computer interface.

Abstract: A system and methods for protecting the health of a user and the user's physiological data from unauthorized access by a third party during the operation of a neural implant is described. Based on a detected change in the internal state of the neural implant, or the detection of unauthorized access, an emergency system configuration change can be performed. One such emergency system configuration involves deactivating the implant to protect the user. The method can be for controlling a neural device in an implanted system. The method can include monitoring, by a monitoring device, the neural device; detecting, by the monitoring device, a condition associated with the neural device; and based on the condition detected by the monitoring device, deactivating the neural device.

Abstract: The present disclosure relates to an array of electrodes and integrated electronics on a flexible scaffolding, with the ability to collapse into an axial configuration suitable for deploying through a narrow cylindrical channel. The electrode arrays can be placed into the ventricular system of the brain, blood vessels of the brain, and/or into other body cavities, constituting a minimally invasive platform for precise spatial and temporal localization of electrical activity within the brain and/or body, and precise electrical stimulation of tissue, to diagnose and restore function in conditions caused by abnormal electrical activity in the brain, nervous system, and/or elsewhere in the body.

Abstract: A system for detecting a neurological state of a brain of a patient is disclosed. The system comprises one or more recording arrays, a database, and a processor. The recording arrays comprise a plurality of recording electrodes having a diameter of less than about 1 mm and spaced by less than about 1 mm, and are configured to be minimally invasively inserted to the brain to record electrical signals from a target recording site. The database stores electrophysiological data relating to known electrophysiological signatures associated with neurological states. The processor is configured to receive recorded signals from the recording arrays, access the electrophysiological data from the database, identify electrophysiological signatures in the recorded signals based on the electrophysiological data, and determine the neurological state of the brain based on the identified electrophysiological signatures.

Abstract: A medical device system that can include a medical device configured to sense data associated with the subject or receive control input, an external device communicably coupled to the medical device, a storage medium communicably coupled to the external device, and one or more communications interfaces between the medical device, the external device, and the storage medium or components thereof, wherein the one or more communications interfaces comprise an encryption protocol.

Abstract: A neural device system that can include a neural device configured to sense data associated with the subject or receive control input, an external device communicably coupled to the neural device, a storage medium communicable coupled to the external device, and one or more communications interfaces between the neural device, the external device, and the storage medium or components thereof, wherein the one or more communications interfaces comprise an encryption protocol.

Abstract: A system for performing spinal cord stimulation on a subject is disclosed. The system comprises one or more recording arrays, at least one stimulation array, and a processor. The recording arrays, which may be minimally invasively inserted to a target recording site of the brain, include recording electrodes having a diameter of less than about 1 mm and having a spacing of less than about 1 mm therebetween. The stimulation array, which may be minimally invasively inserted to a target stimulation site within the nervous tissue, includes stimulation electrodes. The processor is configured to receive more recorded signals from the recording arrays at the target recording site, determine an electrophysiological state of the brain based on the recorded signals, and deliver electrical stimulation to the target stimulation site through the stimulation array based on the determined electrophysiological state in order to affect the electrophysiological state.

Abstract: A systems and methods for calibrating a neural device using transfer learning techniques. The methods can include aggregating calibration data across a user population to define a global dataset, identifying similar data segments across the global dataset to define a task-independent training dataset, training a feature extraction model based on the task-independent training dataset to define a trained, task-independent feature extraction model, receiving the calibration data from a user calibrating the neural device, and calibrating a user-specific feature extraction model using the trained, task-independent feature extraction model and the calibration data.

Abstract: A system for performing deep brain stimulation on a brain of a patient is disclosed. The system comprises one or more recording arrays, at least one stimulation array, and a processor. The recording arrays, which may be minimally invasively inserted to a target recording site of the brain, include recording electrodes having a diameter of less than about 1 mm and having a spacing of less than about 1 mm therebetween. The stimulation array, which may be inserted to a target stimulation site within the deep brain, includes at least one stimulation electrode. The processor is configured to receive one or more recorded signals from the recording arrays at the target recording site, determine a neurological state of the brain based on the recorded signals, and deliver electrical stimulation to the target stimulation site through the stimulation array based on the neurological state in order to electrically stimulate the brain.

Abstract: A neural device system that can include a neural device configured to sense data associated with the subject or receive control input, an external device communicably coupled to the neural device, a storage medium communicable coupled to the external device, and one or more communications interfaces between the neural device, the external device, and the storage medium or components thereof, wherein the one or more communications interfaces comprise an encryption protocol.

Abstract: A medical device system that can include a medical device configured to sense data associated with the subject or receive control input, an external device communicably coupled to the medical device, a storage medium communicably coupled to the external device, and one or more communications interfaces between the medical device, the external device, and the storage medium or components thereof, wherein the one or more communications interfaces comprise an encryption protocol.

Abstract: A system for performing spinal cord stimulation on a subject is disclosed. The system comprises one or more recording arrays, at least one stimulation array, and a processor. The recording arrays, which may be minimally invasively inserted to a target recording site of the brain, include recording electrodes having a diameter of less than about 1 mm and having a spacing of less than about 1 mm therebetween. The stimulation array, which may be minimally invasively inserted to a target stimulation site within the nervous tissue, includes stimulation electrodes. The processor is configured to receive more recorded signals from the recording arrays at the target recording site, determine an electrophysiological state of the brain based on the recorded signals, and deliver electrical stimulation to the target stimulation site through the stimulation array based on the determined electrophysiological state in order to affect the electrophysiological state.

Abstract: A system for performing deep brain stimulation on a brain of a patient is disclosed. The system comprises one or more recording arrays, at least one stimulation array, and a processor. The recording arrays, which may be minimally invasively inserted to a target recording site of the brain, include recording electrodes having a diameter of less than about 1 mm and having a spacing of less than about 1 mm therebetween. The stimulation array, which may be inserted to a target stimulation site within the deep brain, includes at least one stimulation electrode. The processor is configured to receive one or more recorded signals from the recording arrays at the target recording site, determine a neurological state of the brain based on the recorded signals, and deliver electrical stimulation to the target stimulation site through the stimulation array based on the neurological state in order to electrically stimulate the brain.

Abstract: A systems and methods for calibrating a neural device using transfer learning techniques. The methods can include aggregating calibration data across a user population to define a global dataset, identifying similar data segments across the global dataset to define a task-independent training dataset, training a feature extraction model based on the task-independent training dataset to define a trained, task-independent feature extraction model, receiving the calibration data from a user calibrating the neural device, and calibrating a user-specific feature extraction model using the trained, task-independent feature extraction model and the calibration data.

Abstract: Disclosed herein are systems and methods for neural interfaces. Neural interfaces may form minimally invasive and high-scalable bidirectional brain-computer interfaces, which may be used in the treatment of a variety of disorders of the brain and nervous system. Disclosed are methods for a minimally invasive technique for implanting neural interfaces, a neural interface configured to be placed between the brain and the dura and configured to record from and/or stimulate the cortical surface. Also disclosed are methods for attaching a plurality of microelectrode arrays to form a neural interface device, and fabricating neural interfaces including microelectrode arrays and pockets to facilitate their insertion. The disclosed systems and methods also include neural decoding techniques.

Abstract: The present disclosure is directed to systems and methods for endovascular electroencephalography (EEG) and electrocorticography (ECoG) systems. In some embodiments, the disclosed systems include electrode arrays that are configured to record and/or stimulate brain tissue via placement within blood vessels of the brain. Venous and arterial EEG and ECoG electrodes, ambulatory EEG and ECoG systems, and transcutaneous access and signal control systems for general and ambulatory endovascular electroencephalography (EEG) and electrocorticography (ECoG), as well as endovascular neural stimulating electrodes are discussed.

Abstract: Disclosed are systems and methods for circuit- and system-level techniques and approaches for data encryption in scalable, high-bandwidth, bidirectional neural interfaces. In some embodiments, the disclosed systems and methods may be configured to encrypt neural data as close as possible to the data source, and before the data is transmitted out of the body. In some embodiments, the disclosed systems and methods may utilize hardware-based approaches, including those involving modified analog-to-digital converters, and symmetric cryptographic algorithms.

Abstract: The present disclosure relates to a method of generating visual percepts using conformal electrode arrays. The electrode arrays can be placed into the ventricular system or cerebral venous sinuses, which function as minimally invasive techniques for precise spatial and temporal localization of electrical activity within the brain, and precise electrical stimulation of brain tissue, to diagnose and restore function in conditions caused by abnormal electrical activity in the brain. The disclosure further comprises a system for using these arrays to generate time-varying electric fields to stimulate the visual pathways of the brain, including the optic radiations and the occipital cortex, in ways that lead to visual perception.

Abstract: The present disclosure relates to a method of generating visual percepts using conformal electrode arrays. The electrode arrays can be placed into the ventricular system or cerebral venous sinuses, which function as minimally invasive techniques for precise spatial and temporal localization of electrical activity within the brain, and precise electrical stimulation of brain tissue, to diagnose and restore function in conditions caused by abnormal electrical activity in the brain. The disclosure further comprises a system for using these arrays to generate time-varying electric fields to stimulate the visual pathways of the brain, including the optic radiations and the occipital cortex, in ways that lead to visual perception.