Patents by Inventor Benjamin J. Hackel

Benjamin J. Hackel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • AFFIBODY PROTEINS SPECIFIC FOR B7-H3 (CD276)
    Publication number: 20210340257
    Abstract: Affibody polypeptides that specifically bind to B7-H3 are provided. Exemplary anti-B7-H3 affibodies are provided. The affibody polypeptides specifically recognize and bind to B7-H3 with high affinity.
    Type: Application
    Filed: August 22, 2019
    Publication date: November 4, 2021
    Inventors: Lotfi Abou-Elkacem, Juergen Karl Willmann, Benjamin J. Hackel, Lawrence Arthur Stern, Patrick Samuel Lown, Amelie Margarete Marianne Lutz, Rakesh Kumar Bam
  • Cystine knot peptides that bind alpha-V-beta-6 integrin
    Patent number: 9206237
    Abstract: Disclosed are peptides comprising a molecular scaffold portion and a loop portion that binds to integrin ?v?6. This integrin is expressed on pancreatic tumors, making the peptides useful as imaging agents, among other uses. The peptides showed single-digit nanomolar dissociation constants similar to antibodies used clinically for imaging and therapy. The peptides rapidly accumulated in ?v?6-positive tumors, which led to excellent tumor-to-normal contrast. The peptides are specific for the targeted integrin ?v?6 receptors expressed on orthotopic pancreatic tumors and various xenografts used. Additionally, pharmacokinetic-stabilization strategies endowed knots with rapid renal clearance, which significantly reduced off-target dosing.
    Type: Grant
    Filed: May 21, 2014
    Date of Patent: December 8, 2015
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Richard H. Kimura, Sanjiv S. Gambhir, Benjamin J. Hackel, Robert Teed, Bin Shen, Frederick T Chin, Zhen Cheng
  • CYSTINE KNOT PEPTIDES THAT BIND ALPHA-V-BETA-6 INTEGRIN
    Publication number: 20140271469
    Abstract: Disclosed are peptides comprising a molecular scaffold portion and a loop portion that binds to integrin ?v?6. This integrin is expressed on pancreatic tumors, making the peptides useful as imaging agents, among other uses. The peptides showed single-digit nanomolar dissociation constants similar to antibodies used clinically for imaging and therapy. The peptides rapidly accumulated in ?v?6-positive tumors, which led to excellent tumor-to-normal contrast. The peptides are specific for the targeted integrin ?v?6 receptors expressed on orthotopic pancreatic tumors and various xenografts used. Additionally, pharmacokinetic-stabilization strategies endowed knots with rapid renal clearance, which significantly reduced off-target dosing.
    Type: Application
    Filed: May 21, 2014
    Publication date: September 18, 2014
    Applicant: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Richard H. Kimura, Sanjiv S. Gambhir, Benjamin J. Hackel, Robert Teed, Bin Shen, Frederick T Chin, Zhen Cheng